28 research outputs found
Comparison of the suitability of two lichen species and one higher plant for monitoring airborne heavy metals
Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting
Detection of cardiac allograft vasculopathy by multi-layer left ventricular longitudinal strain in heart transplant recipients
Integrating importance and intensity: a novel approach to normalize measurement of neighbour effects
The vaccine adjuvant extra domain A from fibronectin retains its proinflammatory properties when expressed in tobacco chloroplasts
Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium
Proteins, drug targets and the mechanisms they control : the simple truth about complex networks
Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new level of knowledge about how a drug target is wired into the control circuitry of a complex cellular network. Here we review general homeostatic principles of cellular networks that enable the cell to be resilient in the face of molecular perturbations, while at the same time being sensitive to subtle input signals. Insights into such mechanisms may facilitate the development of combination therapies that take advantage of the cellular control circuitry, with the aim of achieving higher efficacy at a lower drug dosage and with a reduced probability of drug-resistance development