28 research outputs found
Getting Acquainted with Kant
My question here concerns whether Kant claims that experience has
nonconceptual content, or whether, on his view, experience is
essentially conceptual. However there is a sense in which this debate
concerning the content of intuition is ill-conceived. Part of this has
to do with the terms in which the debate is set, and part to do with
confusion over the connection between Kant’s own views and contemporary
concerns in epistemology and the philosophy of mind. However, I think
much of the substance of the debate concerning Kant’s views on the
content of experience can be salvaged by reframing it in terms of a
debate about the dependence relations, if any, that exist between
different cognitive capacities. Below, in Section 2, I clarify the
notion of ‘content’ I take to be at stake in the interpretive debate.
Section 3 presents reasons for thinking that intuition cannot have
content in the relevant sense. I then argue, in Section 4, that the
debate be reframed in terms of dependence. We should distinguish between
Intellectualism, according to which all objective representation
(understood in a particular way) depends on acts of synthesis by the
intellect, and Sensibilism, according to which at least some forms of
objective representation are independent of any such acts (or the
capacity for such acts). Finally, in Section 5, I further elucidate the
cognitive role of intuition. I articulate a challenge which Kant
understands alethic modal considerations to present for achieving
cognition, and argue that a version of Sensibilism that construes
intuition as a form of acquaintance is better positioned to answer this
challenge than Intellectualism
The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia.
RATIONALE: The NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://www.newmeds-europe.com ) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia. OBJECTIVES: This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere. METHODS: The battery consists of the five-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a three-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel non-matching to sample-based tasks for measuring spatial working memory and paired-associates learning for measuring long-term memory. RESULTS: The rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks. CONCLUSION: This battery of tests constitutes an extensive tool package for both model characterisation and pre-clinical drug discovery.This work was supported by the Innovative Medicine Initiative Joint Undertaking under grant agreement no. 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013). The authors thank Charlotte Oomen for valuable comments on the manuscript.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00213-015-4007-