Social entrepreneurship : an exploratory citation analysis

Research on Social Entrepreneurship became a growing field of interest during the past decades. However, as the heterogeneity of investigated topics is rather large the purpose of this contribution is to provide an overview of the current state of research on Social Entrepreneurship. In doing so previous research is structured to identify major contributions and thereby key discussion lines within this field. Based on a bibliometric citation analysis of 129 core papers and 5,228 cited references, five topic clusters are identified within the field of Social Entrepreneurship: 1) Definitions and conceptual approaches, 2) Impetus, 3) Personality, 4) Impact and performance, and 5) Future research agenda. By reflecting the literature of each discussion line, a framework for the advancement of Social Entrepreneurship research is provided

Phytotherapy in Inflammatory Lung Diseases: An Emerging Therapeutic Interventional Approach

Chronic obstructive pulmonary disease (COPD) and asthma are the most common inflammatory respiratory diseases related to an increase in mortality and morbidity. Generally, bronchodilators, ß- agonists, anticholinergics and theophylline used for treatment in these conditions and administered by inhalation for delivery, have localized and systematic effects. The adverse effects are due to pharmacodynamic and pharmacokinetic changes and especially drug-drug and drug-disease interactions. However, phytotherapy is classical and widespread throughout the world for the treatment of ailments. This chapter highlights cellular and molecular mediators involved in COPD and asthma, the shortcomings of current therapies and the emerging need of phytomedicines. Phytomedicine supports respiratory physiology, bronchial action and possesses antioxidants to maintain homeostasis

Calcium and cancer: targeting Ca2+ transport

Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted