14 research outputs found
Dichloroacetate treatment accelerates the development of pathology in rodent autosomal recessive polycystic kidney disease
Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease
A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1
Ciliary delivery of polycystin-1 depends on a conserved (K/R/Q)VxPx motif. The signal enables Arf4 GTPase binding and assembly of a multimeric trafficking complex. Functional importance of Arf4 and Rab8 in ciliary trafficking is shown. The studies offer the first unifying molecular rationale for human cystic kidney diseases and retinopathies