Deprivation and cancer incidence in a de-industrialised and highly ageing area. [Deprivazione e incidenza di cancro in un\u2019area ex-industriale a forte invecchiamento].

Abstract Aims: The analysis by tumor site, age groups and gender of the 1999-2003 cancer incidence in Genoa province population clusters in relationships with the socio-economic (SE) deprivation, evaluating if the observed associations confirmed the literature. Methods: The SIR of all malignant cancers (but not melanoma skin cancers) and 35 sites were computed by deprivation cluster, gender and age groups (all ages, 0-64, 65+ years), evaluating the variance in SIR among groups. The SE clusters were individuated by the Genoa Deprivation Index (GDI), derived from the re-parameterisation of the LRDI (Liguria Region Deprivation Index) inside the territorial limits of Genoa province. Results: All malignant cancers combined showed no association with deprivation in both sexes due to a balance of positive and negative observed associations. Increasing trend at decreasing deprivation (linear negative associations) regarded colon, melanoma, skin carcinomas, breast, prostate, meningioma and myelodysplastic syndromes, while the opposite (linear positive associations) were observed for oropharynx, oesophagus, stomach, rectum, liver, lung, mesothelioma, uterine corpus, testis, kidney, brain, Hodgkin\u2019s and non-Hodgkin\u2019s lymphomas and myeloma. Conclusions: The combined effects of population ageing, de-industrialisation and increasing role of touristic activities in Liguria induced a situation forerunner of the possible post-industrial Western countries development outcomes. Our study confirmed some known associations between deprivation and cancer incidence occurrence: both the positive with smoke- and alcohol-consumption (oropharynx, oesophagus, lung) and infectious risks (rectum, liver) and the negative ones with diet, obesity and sedentariness (colon, breast, prostate) and sun recreational exposure (skin carcinomas, melanoma). Also the controversial evidences regarding brain and haematological tumours seemed confirmed. From the future experiences of re-allocation of resources on the Genoa territory could derive input on readjustment policies on social and health resources redistribution at national level

Methods to study the deprivation and its relationships with cancer incidence in a local area [Metodi per lo studio della deprivazione e le sue relazioni con l\u2019incidenza del cancro in un\u2019area locale].

Abstract Aim: This study was aimed at finding the best method to describe the relationships between cancer incidence and deprivation of population at a local level (the Genoa province). Methods: The population was clustered using the National Deprivation Index (NDI) and the Genoa Deprivation Index (GDI), both using data drawn from the 2001 Census, either at municipality or at district levels. The NDI and GDI used were drawn from the NDI 2001 and the Liguria Region Deprivation Index 2001 (LRDI), re-parameterised on the values of areas pertaining to the Genoa province considering the quintiles of the population. In the building of both original indexes five traits representing the multi-dimensionality of the social and material deprivation concept were selected, but each one resulted composed by quite opposite variables. The derived indexes were applied to clustering Genoa province population computing for each cluster the cancer incidence occurrence in the period 1999-2003. For the five deprivation clusters of population, individuated aggregating the 91 areas of the province on the basis of the two indexes, the Standardised Incidence Ratios (SIR) were computed for all malignant cancers combined (skin carcinomas excluded) and 35 sites. The observed SIR and their 95% confidence intervals were calculated by gender and age (all ages, 0-64 years and 65+ years). To evaluate if deprivation influenced the incidence, an analysis was conducted between SIR group variances. Results: From the application of the GDI, many significant associations between cancer incidence and deprivation surfaced, particularly for women. However, the NDI did not correctly identify the main part of the negative linear trends whereas the GDI did so. The lacking of statistical significance in all cancers combined distribution by GDI in men was mainly explained by the opposite trends in lung and prostate cancers, while in women the breast negative trend was balanced by a major number of different sites. Conclusions: Although the GDI cannot be considered a \u201cpure\u201d deprivation index, it does seem to be useful for public health purposes due to its capability of discriminating SE clusters in a fairly homogenous population, like the Liguria one

Incidenza delle neoplasie per caratteristiche di deprivazione socio-economica delle aree di residenza.

cancer incidence - deprivatio

RETOP \u2013 Liguria: il Registro dei Tumori di sospetta Origine Professionale, i rischi accertati e l\u2019interazione con i Dipartimenti di Prevenzione delle ASL liguri.

risultati del Registro dei Tumori di sospetta Origine Professionale in Liguri

Estimates of cancer burden in Liguria.

Aims and background. The regional health care system of Liguria caters for a resident population which is among the oldest in Europe. One population-based cancer registry is present in the region, providing incidence and survival data for the Genoa province (covering 55% of the regional population). This paper will estimate the incidence, prevalence and mortality in the Liguria region for cancers of the lung, breast, prostate, colon-rectum, stomach and uterine cervix and melanoma of the skin in 1970-2015. Methods. The estimated figures were obtained by applying the MIAMOD method. Starting from mortality and survival data, incidence and prevalence were derived using a statistical back-calculation approach. Survival was modeled on the basis of published data from the Italian cancer registries. The MIAMOD method was applied also to estimate the colorectal cancer incidence, mortality and prevalence rates in the Ligurian provinces in the period 1988-2015. Results. In 2012 about 1,500 new cases of breast cancer were expected in Ligurian women. The estimates for the other cancer sites were considerably lower, ranging from 839 (colon-rectum) to 54 (cervix). In men about 1,400 new cases were estimated for prostate cancer, while the incidence for the other sites ranged from 1,118 (colon-rectum) to 208 (skin melanoma). The breast cancer prevalence rate was more than 10 times the incidence rate in women, and the lung cancer prevalence rate was more than double the incidence rate in both sexes. Mortality rates were highest for lung cancer in men and breast cancer in women; the lowest rates were estimated for melanoma and cancer of the uterine cervix. Conclusion. In Liguria a large portion of the health expenditure has been devoted to diagnostic and therapeutic resources. This may have contributed to the reduction of mortality rates and to the improvement of cancer survival. This phenomenon, added to population aging, will inflate the cancer prevalence. One of the major challenges for the Liguria region is to face the increasing demand for oncology services

Valutazione ecologica rapida dell\u2019associazione fra rischio di malattia (mortalit\ue0/incidenza neoplasie) e rischi ambientali. Esempio di valutazione dei rischi ambientali in piccole aree del Comune di Genova.

Valutazione ecologica rapida dell\u2019associazione fra rischio di malattia (mortalit\ue0/incidenza neoplasie) e rischi ambientali