314 research outputs found
Vertex operator algebras and operads
Vertex operator algebras are mathematically rigorous objects corresponding to
chiral algebras in conformal field theory. Operads are mathematical devices to
describe operations, that is, -ary operations for all greater than or
equal to , not just binary products. In this paper, a reformulation of the
notion of vertex operator algebra in terms of operads is presented. This
reformulation shows that the rich geometric structure revealed in the study of
conformal field theory and the rich algebraic structure of the theory of vertex
operator algebras share a precise common foundation in basic operations
associated with a certain kind of (two-dimensional) ``complex'' geometric
object, in the sense in which classical algebraic structures (groups, algebras,
Lie algebras and the like) are always implicitly based on (one-dimensional)
``real'' geometric objects. In effect, the standard analogy between
point-particle theory and string theory is being shown to manifest itself at a
more fundamental mathematical level.Comment: 16 pages. Only the definitions of "partial operad" and of "rescaling
group" have been improve
The Impact of Non-Equipartition on Cosmological Parameter Estimation from Sunyaev-Zel'dovich Surveys
The collisionless accretion shock at the outer boundary of a galaxy cluster
should primarily heat the ions instead of electrons since they carry most of
the kinetic energy of the infalling gas. Near the accretion shock, the density
of the intracluster medium is very low and the Coulomb collisional timescale is
longer than the accretion timescale. Electrons and ions may not achieve
equipartition in these regions. Numerical simulations have shown that the
Sunyaev-Zel'dovich observables (e.g., the integrated Comptonization parameter
Y) for relaxed clusters can be biased by a few percent. The Y-mass relation can
be biased if non-equipartition effects are not properly taken into account.
Using a set of hydrodynamical simulations, we have calculated three potential
systematic biases in the Y-mass relations introduced by non-equipartition
effects during the cross-calibration or self-calibration when using the galaxy
cluster abundance technique to constraint cosmological parameters. We then use
a semi-analytic technique to estimate the non-equipartition effects on the
distribution functions of Y (Y functions) determined from the extended
Press-Schechter theory. Depending on the calibration method, we find that
non-equipartition effects can induce systematic biases on the Y functions, and
the values of the cosmological parameters Omega_8, sigma_8, and the dark energy
equation of state parameter w can be biased by a few percent. In particular,
non-equipartition effects can introduce an apparent evolution in w of a few
percent in all of the systematic cases we considered. Techniques are suggested
to take into account the non-equipartition effect empirically when using the
cluster abundance technique to study precision cosmology. We conclude that
systematic uncertainties in the Y-mass relation of even a few percent can
introduce a comparable level of biases in cosmological parameter measurements.Comment: 10 pages, 3 figures, accepted for publication in the Astrophysical
Journal, abstract abridged slightly. Typos corrected in version
Toxoplasma effectors targeting host signaling and transcription
Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during invasion of host cells. These early morphological studies were followed by the exploration of the cellular contents of these secretory organelles, revealing them to be comprised of highly divergent protein families with few conserved domains or predicted functions. In parallel, studies on host-pathogen interactions identified many host signaling pathways that were mysteriously altered by infection. It was only with the advent of forward and reverse genetic strategies that the connections between individual parasite effectors and the specific host pathways that they targeted finally became clear. The current repertoire of parasite effectors includes ROP kinases and pseudokinases that are secreted during invasion and that block host immune pathways. Similarly, many secretory GRA proteins alter host gene expression by activating host transcription factors, through modification of chromatin, or by inducing small noncoding RNAs. These effectors highlight novel mechanisms by whichhas learned to harness host signaling to favor intracellular survival and will guide future studies designed to uncover the additional complexity of this intricate host-pathogen interaction
Heat Transport in low-dimensional systems
Recent results on theoretical studies of heat conduction in low-dimensional
systems are presented. These studies are on simple, yet nontrivial, models.
Most of these are classical systems, but some quantum-mechanical work is also
reported. Much of the work has been on lattice models corresponding to phononic
systems, and some on hard particle and hard disc systems. A recently developed
approach, using generalized Langevin equations and phonon Green's functions, is
explained and several applications to harmonic systems are given. For
interacting systems, various analytic approaches based on the Green-Kubo
formula are described, and their predictions are compared with the latest
results from simulation. These results indicate that for momentum-conserving
systems, transport is anomalous in one and two dimensions, and the thermal
conductivity kappa, diverges with system size L, as kappa ~ L^alpha. For one
dimensional interacting systems there is strong numerical evidence for a
universal exponent alpha =1/3, but there is no exact proof for this so far. A
brief discussion of some of the experiments on heat conduction in nanowires and
nanotubes is also given.Comment: 78 pages, 25 figures, Review Article (revised version
Sine-Gordon Model - Renormalization Group Solutions and Applications
The sine-Gordon model is discussed and analyzed within the framework of the
renormalization group theory. A perturbative renormalization group procedure is
carried out through a decomposition of the sine-Gordon field in slow and fast
modes. An effective slow modes's theory is derived and re-scaled to obtain the
model's flow equations. The resulting Kosterlitz-Thouless phase diagram is
obtained and discussed in detail. The theory's gap is estimated in terms of the
sine-Gordon model paramaters. The mapping between the sine-Gordon model and
models for interacting electrons in one dimension, such as the g-ology model
and Hubbard model, is discussed and the previous renormalization group results,
obtained for the sine-Gordon model, are thus borrowed to describe different
aspects of Luttinger liquid systems, such as the nature of its excitations and
phase transitions. The calculations are carried out in a thorough and
pedagogical manner, aiming the reader with no previous experience with the
sine-Gordon model or the renormalization group approach.Comment: 44 pages, 7 figure
Developing and evaluating the implementation of a complex intervention: using mixed methods to inform the design of a randomised controlled trial of an oral healthcare intervention after stroke
<p>Abstract</p> <p>Background</p> <p>Many interventions delivered within the stroke rehabilitation setting could be considered complex, though some are more complex than others. The degree of complexity might be based on the number of and interactions between levels, components and actions targeted within the intervention. The number of (and variation within) participant groups and the contexts in which it is delivered might also reflect the extent of complexity. Similarly, designing the evaluation of a complex intervention can be challenging. Considerations include the necessity for intervention standardisation, the multiplicity of outcome measures employed to capture the impact of a multifaceted intervention and the delivery of the intervention across different clinical settings operating within varying healthcare contexts. Our aim was to develop and evaluate the implementation of a complex, multidimensional oral health care (OHC) intervention for people in stroke rehabilitation settings which would inform the development of a randomised controlled trial.</p> <p>Methods</p> <p>After reviewing the evidence for the provision of OHC following stroke, multi-disciplinary experts informed the development of our intervention. Using both quantitative and qualitative methods we evaluated the implementation of the complex OHC intervention across patients, staff and service levels of care. We also adopted a pragmatic approach to patient recruitment, the completion of assessment tools and delivery of OHC, alongside an attention to the context in which it was delivered.</p> <p>Results</p> <p>We demonstrated the feasibility of implementing a complex OHC intervention across three levels of care. The complementary nature of the mixed methods approach to data gathering provided a complete picture of the implementation of the intervention and a detailed understanding of the variations within and interactions between the components of the intervention. Information on the feasibility of the outcome measures used to capture impact across a range of components was also collected, though some process orientated uncertainties including eligibility and recruitment rates remain to be further explored within a Phase II exploratory trial.</p> <p>Conclusions</p> <p>Complex interventions can be captured and described in a manner which facilitates evaluation in the form of exploratory and subsequently definitive clinical trials. If effective, the evidence captured relating to the intervention context will facilitate translation into clinical practice.</p
First Colombian Multicentric Newborn Screening for Congenital Toxoplasmosis
Congenital toxoplasmosis can result in permanent sequel as blindness or neurological damage in children and it seems to be more severe in South America than in other continents. There is a lack of information about this frequency in Colombia, where no control program is established, although it is a recognized cause of potentially preventable congenital blindness. We propose the first Colombian multicentric study to determine the frequency and impact of congenital toxoplasmosis. More than 15,000 newborns in seven cities were studied. Newborns were tested at birth by doing a cord blood test for toxoplasmosis. Additionally, children from mothers with history of toxoplasmosis acquired during pregnancy were recalled for a follow-up. The program identified fifteen children otherwise undiagnosed; three of these children died as consequence of congenital toxoplasmosis. The frequency of the congenital infection varied significantly between cities, being higher in Armenia and Florencia, intermediate in Bogota, Bucaramanga and Barranquilla and very low in western cities such as Cucuta and Riohacha. For the first time a significant correlation was found between mean rainfall at the city and the incidence of this congenital infection
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