29 research outputs found
The prevalence of lymphoedema in women who attended an information and exercise class to reduce the risk of breast cancer-related upper limb lymphoedema
In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei
Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host
Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis