7 research outputs found
Cyclostratigraphic studies of sediments from Lake Van (Turkey) based on their uranium contents obtained from downhole logging and paleoclimatic implications
Machines first, humans second: on the importance of algorithmic interpretation of open chemistry data
miR-410 induces both epithelialâmesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer
Carboxypeptidase G2-based gene-directed enzymeâprodrug therapy: a new weapon in the GDEPT armoury
Gene-directed enzyme-prodrug therapy (GDEPT) aims to improve the therapeutic ratio ( benefit versus toxic side-effects) of cancer chemotherapy. A gene encoding a 'suicide' enzyme is introduced into the tumour to convert a subsequently administered non-toxic prodrug into an active drug selectively in the tumour, but not in normal tissues. Significant effects can now be achieved in vitro and in targeted experimental models, and GDEPT therapies are entering the clinic. Our group has developed a GDEPT system that uses the bacterial enzyme carboxypeptidase G2 to convert nitrogen mustard prodrugs into potent DNA crosslinking agents, and a clinical trial of this system is pending