38 research outputs found

    ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits

    Get PDF

    Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase

    No full text
    The structure of ent-copalyl diphosphate synthase (CPS) reveals three α-helical domains (α, β, γ), as also observed in the related diterpene cyclase taxadiene synthase. However, active sites are located at the interface of the βγ domains in CPS but exclusively in the α domain of taxadiene synthase. Modular domain architecture in plant diterpene cyclases enables the evolution of alternative active sites and chemical strategies for catalyzing isoprenoid cyclization reactions

    Organoactinide Chemistry: Properties of Compounds Having Metal—Carbon Bonds Only to π-Bonded Ligands

    No full text
    corecore