A Improved Control System Using Digital Technology For A Wind Tunnel Forced – Oscillation Rig.

A Improved Control System For A Forced-Oscillation Rig For Measurement Of Pitch/Yaw Damping Derivatives In The NAL 1 .2m Derivatives Wind Tunnel Has Bee Designed And Developed. The Basic Principles Of The System Are Similar To Those Of A Existing Control System Developed For The Same Forced-Oscillation Rig. The Present System In Corporate Certain Features Such As The Use Of Digital Techniques For Fine Tuning And Automatic Switching Of Phase Tracking Control From Closed-Loop To Open-Loop Mode Operation . These Features Facilitate Testing. Even When The Model Is Subject, To Relatively Large Random Disturbances Due Either To Large Flow U Steadiness A D/Or Separated Flow Over Model Occurring At High Incidences. Performance Of The Control System Was Evaluated Initially In Bench Tests .The System Was Later Successfully Employed For Pitch-Damping Measurements at Mach Numbers up To 3 .T3 In The NAL 1 .2 Transonic Blowdown Tunnel

A NOVEL VALIDATED HEADSPACE GAS CHROMATOGRAPHY METHOD FOR THE SIMULTANEOUS QUANTIFICATION OF THREE ORGANIC VOLATILE IMPURITIES IN ENROFLOXACIN PURE AND PHARMACEUTICAL DOSAGE FORMS

Objective: This article describes a novel, simple, and rapid gas chromatographic method for quantification of three organic volatile impurities (OVIs) present in enrofloxacin and its pharmaceutical dosage forms. Methods: As stationary phase using ZB-624 30 m×0.53 mm, 3.0 μ column with flame ionized detector at 250°C. The injector temperature is maintained at 180°C. The nitrogen gas was used as a carrier gas with a flow rate of 4.0 mL/min. The method involved a thermal gradient elution. The total run time is 21.14 min. Results: The retention time of three OVIs taken individually and in spiked standard solutions were determined. The retention times are 2.30 min for methanol, 7.07 min for 1-butanol, and 8.48 min for toluene, respectively. The % relative standard deviation for six injections should be not more than 10%. The % recovery ranges from 85 to 115%. The correlation coefficient (r2) for linearity is not <0.99. The limit of quantification was found to be 260 ppm for methanol, 101 ppm for 1-butanol, and 56 ppm for toluene. Furthermore, verified precision, ruggedness, robustness, solution stability, and pharmaceutical analysis. Conclusion: All the obtained results are found within the acceptable limits. The proposed method has been successfully applied for the quantification of OVIs present in enrofloxacin pure and its pharmaceutical dosage forms

HPLC METHOD DEVELOPMENT AND VALIDATION OF LERCANIDIPINE HCL AND ATENOLOL, CHARACTERIZATION OF ITS DEGRADANTS BY LC-MS/MS

Objective: An assay method was developed and validated for the simultaneous estimation of Lercanipine HCl and atenolol using RP-HPLC. Methods: An effective chromatographic separation was achieved using waters symmetry C18 column of dimensions 150x4.6 mm, 3.5 μm, as a stationary phase. 0.1 percent ortho phosphoric acid and acetonitrile in 50:50 v/v was used as a mobile process with a rate of flow 1 ml/min and UV detection was carried out at 230 nm, respectively. Isocratic chromatography at ambient temperature was performed. Results: Lercanidipine HCl and atenolol were separated by a running time of around 8 min. at 2.925 min. and 6.482 min. Respectively. By injecting the norm six times, device suitability parameters were studied and the outcomes were well under the acceptance criteria. The linearity analysis was performed at levels ranging from 10% to 150% and the R2 value was found to be 0.999. Conclusion: Assay method validation was performed by using the marketed formulation and found to be within the limit. Degradation tests were conducted and the degradants were characterized by using LC-MS/MS

Analysis of Development Performance Using a Development Index Based on Factor Analysis (Old Title- Constructing Multideminsional Indexes of Economic Structure and Development)

Development involves changes in social, economic and institutional structures. Quantifying development requires a large array of variables with different characteristics often highly correlated. A factor analysis approach using inferential decisions based on computed standard errors is proposed. The significant factors are used to construct sub-indexes of structural characteristics and a new development index (DI). The properties of DI are analysed and contrasted with more traditional measures, real per capita income (RIPC) and the Human Development Index (HDI). The methodology is applied to data on 45 variables for 97 countries for 1995-2004. DI is found to have stronger discriminating power.

Sorghum nitidum (Vahl.)Pers,occurrence, morphology and cytology

The distribution, collection, morphology and cytology ofSorghum nitidum (Vah1) Pers. belonging to the sectionParasorghum of genusSorghum are presented. The species collected in the western ghats of Tamil Nadu and Kerala has 10 normal (A) chromosomes (2n=10) and 3 supernumerary (B) chromosomes, which are reported for the first time in Indian collections

Arabian Sea Mini Warm Pool and its Influenceon Acoustic Propagation

A systematic experiment was conducted in the eastern Arabian Sea for the first time exclusivelyto study the characteristics of the Arabian Sea mini warm pool1. The analysis revealed complexnature of the thermohaline and sonic layer distributions across the Arabian Sea mini warm pool.This mini warm pool was identified between 67.5 oE and 75 oE, where the sea surface temperaturewas in excess of 30.25 oC. At the core of this mini warm pool, warmer (>31.2 oC) and low saline(<34.6 PSU) waters were noticed. Further, very thin sonic layer (< 5 m) was noticed at the miniwarm pool core, which increased eastward and westward. In this study, the acoustic propagationcharacteristics across and outside of the core, i.e., (i) within the mini warm pool core, (ii) easternside of the mini warm pool core, and (iii) western side of the mini warm pool core, were assessedbased on the output of a range-dependant acoustic model. In general, the occurrence of this miniwarm pool was found to alter the propagation characteristics. Better propagation was obtainedwhen the simulation was carried out on the eastern side of this mini warm pool, with source nearthe coast (i.e., downslope condition

VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND EZETIMIBE IN PHARMACEUTICAL DOSAGE FORM

Objective: To develop and validate a rapid, sensitive and specific reverse phase high performance liquid chromatography (RP-HPLC) method for simultaneous determination of Rosuvastatin Calcium and Ezetimibe in a combined dosage form.Methods: The chromatographic separation of the two drugs were achieved using Enable C18G (5 μm, 250 mm x 4.6 mm i. d. column). The drugs were separated in isocratic elution mode with a mobile phase consists of Acetonitrile-Water (75:25, v/v) at a flow rate of 0.6 ml/min and a detection wavelength of 252 nm using a UV detector.Results: The linearity and range for both Rosuvastatin Calcium and Ezetimibe were 5-40 µg/ml (R2= 0.9995) and 5-40 µg/ml (R2= 0.9992), respectively. Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the preanalyzed test solution and was found to be 99.6-100.3 % and 99.5-99.9% for Rosuvastatin Calcium and Ezetimibe respectively. The % RSD values for both interday and intraday precision were found to be<2%.Conclusion: A rapid, sensitive and specific RP-HPLC method was developed and validated for simultaneous determination of Rosuvastatin Calcium and Ezetimibe in a combined dosage form and hence, it can be used in the quality control analysis of an active pharmaceutical ingredient and pharmaceutical dosage form.Â

VLSI Implementation of Medical Image Fusion Using DWT-PCA Algorithms

Nowadays, the usage of DIP is more important in the medical field to identify the activities of the patients related to various diseases. Magnetic Resonance Imaging (MRI) and Computer Tomography (CT) scan images are used to perform the fusion process. In brain medical image, MRI scan is used to show the brain structural information without functional data. But, CT scan image is included the functional data with brain activity. To improve the low dose CT scan, hybrid algorithm is introduced in this paper which is implemented in FPGA. The main objective of this work is to optimize performances of the hardware. This work is implemented in FPGA. The combination of Discrete Wavelet Transform (DWT) and Principle Component Analysis (PCA) is known as hybrid algorithm. The Maximum Selection Rule (MSR) is used to select the high frequency component from DWT. These three algorithms have RTL architecture which is implemented by Verilog code. Application Specified Integrated Chips (ASIC) and Field Programmable Gate Array (FPGA) performances analyzed for the different methods. In 180 nm technology, DWT-PCA-IF architecture achieved 5.145 mm2 area, 298.25 mW power, and 124 ms delay. From the fused medical image, mean, Standard Deviation (SD), entropy, and Mutual Information (MI) performances are evaluated for DWT-PCA method