EFFECT OF ZEIN ON CIPROFLOXACIN FLOATING TABLETS

Objective: This work was aimed to formulate and evaluate the effect of zein on Ciprofloxacin HCl floating tablets. According to previous studies, it was set up to be useful against bacteria i.e. Helicobacter pylori which leads to peptic ulcers. Thus, it is quite necessary to enhance the Gastric Retention Time for similar medicines. Methods: 12 different floating tablets of Ciprofloxacin HCl were formulated with wet granulation method with a rise in the concentration of zein. Further, all different formulations prepared were evaluated for different parameters i.e. pre-compression considerations, along with post-compression factors like weight variation, content uniformity, thickness, visual assessment, hardness, friability, buoyancy studies i.e. total floating time as well as floating lag time, swelling index, dissolution and drug release kinetics. Results: The F6 formulation was considered to be among finest formulation with appropriate hardness. It was found that with the increasing concentration of zein, the hardness of tablets was also increased. It showed TFT of more than 7 h, FLT of 310 sec, a swelling index time of 99.5 % in 4 hr, while drug release kinetics was found to follow Higuchi Model. Conclusion: Overall it was also found that HPMCK-100M is more effective as compared to HPMC-K15M and Zein has a major role in increasing the hardness of tablets. In the future, the investigation will be continued with the following studies: An in vivo study and a long-term stability study

Not Available

Not AvailableTechnical Bulletin on Status of Plant Genetic Resources at CAZRINot Availabl

Not Available

Not AvailableNot AvailableNot Availabl

3D PRINTING: A REVIEW ON THE TRANSFORMATION OF ADDITIVE MANUFACTURING

3D printing and nanotechnology have been two of the most important tools in the development of personalized medical treatments. More recently, their alliance has developed in an effort to create new, flexible, multidisciplinary, and/or medical and drug-wise products. Therefore, a comprehensive review of scientific studies, including 3D printing and nanomaterials on the development of new pharmaceutical methods and medical applications for the treatment and prevention of diseases, is presented here with the help of secondary research from most recent articles. 3D printing, also known as additive manufacturing, has held the power of building a new class of active nanocomposites. With the ability to print a layer of complex 3D objects by layer, additional production of nanomaterials can be used in new ways to significantly control architectural structures of all sizes. The high efficiency of embedded nanomaterials can further extend the power of nanocomposites to structures such as gradients in thermal conductivity, converted photonic emissions, and increased energy and reduced weight. According to the survey done by annual industry, around 50% of the market of 3d printing in the industrial sectors is credited to created prototypes by means of photopolymers. While, Formlabs, Stratasys, HP, Desktop Metal, Ultimaker, Carbon, EOS, Nanoscribe and Markforged are among the top additive manufacturers. This work is hereby an effort to focus on different techniques, merits and demerits, applications, recent advances, relation with nanotechnology along with future aspects