ANTIDIABETIC AND ANTIOXIDANT EFFICACY OF BONE MARROW STEM CELLS ON STZE-INDUCED MALE ALBINO WISTAR RATS

Diabetes mellitus is a multi-metabolic disorder that influences more than 348 million people worldwide. A key goal of diabetes treatment is to prevent complications because over time, diabetes can damage the heart, blood vessels, eyes, kidneys, and nerves. Consequently there is an incredible need to develop new and successful therapies for treating diabetic complications early before it causes irreparable tissue damage. Bone marrow derived mesenchymal stem cells (BMSCs) offer significant benefits for clinical application, because they can be easily harvested and, when autologous transplanted, there is no immunological rejection. Moreover, BMSCs can differentiate into a wide variety of cell types. Here, we focused on bone marrow-derived mesenchymal stem cells (MSCs) can transdifferentiate into insulin-producing cells (IPC) under defined conditions  and normalize the glucose level of streptozotocin (STZ)- induced diabetic rats.The main objective of  the study was To evaluate the antidiabetic activity of the Dental pulp cells in Streptozotocin (STZ)-induced diabetic Wistar albino rats.To calculate the biochemical estimation of both normal and treated groups.To study the effects of dental pulp cells on morphological characterization of normal and treated groups. Streptozotocin.,Wistar albino rat.,Insulin.,stem cell.,fibroblas

A Randomised Comparative Clinical Study to assess the efficacy of Snigdhapatra Pindasweda and Matrabasti in the management of Janusandhigatavata w.s.r. to Osteoarthritis of knee

Vata aggravation and Parihani (depletion) of all the Dhatus are inevitable in Vrudhavastha (old age). Hence there is subsequent vitiation of Vata which affects Asthidhatu (due to Ashraya and Ashrayi Sambandha) is common. Sandhigata Vata is one amongst them. The involvement of Marma with Vata Dosha and Dhatukshaya makes disease Yapya. Hence early management prevents disability in the old age. Snehana, Swedana and Basti Chikitsa are the prime line of management in Vatadosha. When the disease is Shula and Grahapradhana, affecting one body part, the Snigdha, Ekangasweda is the ideal treatment. So Snigdhapatra Pindasweda is selected. The need of Snehana, Brumhana, Vatashamana is best achieved by Snehabasti with Vatashamaka Taila (Dashamoola Taila). To assess the synergistic action, combined treatment is planned in the present study. With this in backdrop, a comparative clinical study was planned in 30 patients allotted into 3 groups of 10 each. Group A treated with Snigdhapatra Pindasweda, Group B treated with Matrabasti and Group C treated with both the treatment for 7 days. Within the group result showed statistically significant improvement in all the parameters. In between the groups comparison showed statistically significant difference in stiffness, tenderness, movement of knee joint, Walking - time and WOMAC- Index

Beneficiation studies on beach placer sample for steel making industries

Beneficiation studies were carried out on the Talashil beach placer sample of South Maharastra Coast, India. The sample contains magnetite, ilmenite, rutile, hematite, goethite and chromite as opaque minerals in the sample. The total heavy minerals fraction reaches 53.8 % by weight whereas the total magnetic minerals are 56.9%. It is observed that the 2nd stage DHIMS magnetic fraction contains 65.2 % Fe2O3 with an over all yield of 37.8 % and a 86 % recovery from a containing 26.8 % Fe2O3 feed. This product can be used in the pellet feed for steel making after suitable blending with high-grade iron ore fines

Lower bounds for dilation, wirelength, and edge congestion of embedding graphs into hypercubes

Interconnection networks provide an effective mechanism for exchanging data between processors in a parallel computing system. One of the most efficient interconnection networks is the hypercube due to its structural regularity, potential for parallel computation of various algorithms, and the high degree of fault tolerance. Thus it becomes the first choice of topological structure of parallel processing and computing systems. In this paper, lower bounds for the dilation, wirelength, and edge congestion of an embedding of a graph into a hypercube are proved. Two of these bounds are expressed in terms of the bisection width. Applying these results, the dilation and wirelength of embedding of certain complete multipartite graphs, folded hypercubes, wheels, and specific Cartesian products are computed

Development and Diffusion of Sorghum Improved Cultivars in India: Impact on Growth and Variability in Yield

Sorghum is the third cereal crop after rice and wheat in India, mostly grown under marginal and stress-prone areas of Semi-Arid Tropics (SAT). NARS, ICRISAT and private seed companies are the major stakeholders working for sorghum crop improvement in the last five decades (1960-2012). Altogether more than 256 improved cultivars have been notified and made available to farmers during the same time. The current knowledge about spread and impact of sorghum improved crop varieties in the country is incomplete. The present study made an attempt to address these issues with help of primary as well as secondary sources of information. The analysis has concluded that nearly 80 per cent of total sorghum area is under improved cultivars which helped to increase the country productivity levels by 85 per cent during 1960 and 2010. This aptly proves that role of sorghum improved cultivars in sustaining the higher yields

Development and Diffusion of Sorghum Improved Cultivars In India: Impact on Growth and Stability in Yield

Sorghum [Sorghum bicolor (L.) Moench] is one of the major staple foods for the poorest and most food-insecure people across the semi-arid tropics of the world. Sorghum bicolor ssp. Verticilliflorum is believed to be the progenitor of cultivated sorghum (Harlan, 1972). It is cultivated in wide geographic areas in Africa, Asia, Americas and the Pacific regions. While it is the fifth most important cereal crop in the world after wheat, maize, rice and barley, in India, sorghum is the fourth largest cereal crop after rice, wheat and pearl millet and the second major food crop in Africa after maize. Sorghum is often a recommended option for farmers operating in harsh environments where other crops do poorly, as it can be grown with limited rainfall (400-500 mm) and often without or with limited application of fertilizers and other inputs. In India, sorghum is grown in both rainy (2.6 million ha) and postrainy (3.5 million ha) seasons. An estimated 2 million ha is under forage sorghum, grown in the summer season. Nearly 30-40% of the rainy season sorghum is grown as the sole crop while the rest is cultivated as an intercrop with pulses and oilseeds in India. On the other hand, 90% of postrainy season sorghum is grown as a sole crop, which is most preferred for food purposes

Pigeonpea Baseline and Early Adoption Surveys in South Asia, Insights from TL-II (Phase 1) Project in India.

Pigeonpea is an important pulse crop particularly in the semi-arid tropics of India contributing towards the nutritional security and also generates significant income to small and marginal farmers. Its share in India’s pulse production is around 16%. India is the largest pigeonpea producing country in the world accounting for nearly 67% of the total production. Being a major pigeonpea consumer in the world, India imports around 0.6 million tons of pigeonpea per year to meet the domestic needs from Africa, Nepal and Myanmar. Area and production of pigeonpea in India showed a steady growth until recently. However, the productivity in the country has stagnated between 700 and 800 kg ha-1. Recent initiatives like National Food Security Mission (NFSM), Accelerated Pulse Production Programme (A3P) and enhancement of minimum support price created more interest in pigeonpea growers in the country. Pigeonpea is one of the mandate crops of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) and this premier international institute has been contributing significantly to the genetic improvement and crop management in India and Africa during the last four decades. The generous support received from the Bill and Melinda Gates Foundation (BMGF) has provided ICRISAT an opportunity to work more intensively with its research and development partners to demonstrate the potential of new technologies to enhance the yields, raise the profitability and revive the interest of the farmers in pigeonpea crop in India and the strategy chosen is farmer participatory varietal selection (FPVS). This report synthesizes the efforts made under the Tropical Legumes-II Project during the short period of three years (2007-10) in the states of Andhra Pradesh and Maharashtra for pigeonpea crop improvement in India. Overall, the FPVS results established that the new improved varieties outyielded the respective check varieties in the two states. The diffusion and adoption of these varieties increased significantly in the targeted districts. From the past lessons learnt, the report re-focuses on further efforts needed during the second phase of the project to achieve greater success and impact