13 research outputs found
Morphofunctional characterization of lymphokine-activated killer(LAK) cells in vitro J. Biol. Res.
Development of a method to extend, by Boron neutron capture process, the therapeutic possibilities of the liver autograft
Serine protease detction in mixed lymphocyte cultures: a histochemical method for possible prediction of graft-versus-host disease
Boron Neutron Capture Therapy activity of diffused tumors at Triga Mark II in Pavia
The Boron neutron Capture Therapy research in Pavia has a long tradition: it begun more than 20 years ago at the
Triga Mark II reactor of the University. A technique for the treatment of the hepatic metastases was developed,
consisting in explanting the liver treated with 10B, irradiating it in the thermal column of the reactor, and reimplanting
the organ in the patient. In the last years, the possibility of applying BNCT to the lung tumours using
epithermal collimated neutron beams and without explanting the organ, is being explored. The principal obtained
results of the BNCT research will be presented, with particular emphasis on the following aspects: a) the project
of a new thermal column configuration to make the thermal neutron flux more uniform inside the explanted liver,
b) the Monte Carlo study by means of the MCNP code of the thermal neutron flux distribution inside a patient’s
thorax irradiated with epithermal neutrons, and c) the measurement of the boron concentration in tissues by (n,α)
spectroscopy and neutron autoradiography
Studio di efficacia in vivo della Boron Neutron Capture Therapy applicata ai tumori polmonari diffusi
La BCNT è una radioterapia sperimentale adatta al trattamento di tumori diffusi inoperabili. Lo studio della BNCT dei tumori diffusi del polmone è in corso a Pavia, i risultati ne dimostrano la fattibilità . Il passo successivo è l’irraggiamento di ratti con metastasi polmonari nella colonna termica del reattore di Pavia per verificare l’efficacia del trattamento. Tramite simulazioni di Monte Carlo è stato studiato il set up di irraggiamento: la configurazione prevista permette di impartire dosi di radiazione terapeutiche al tumore, e sotto le soglie di tolleranza ai tessuti sani circostanti. Il tempo di irraggiamento è 10 minuti circa, compatibile con la durata dell’anestesia