15 research outputs found

    Soluble forms of tau are toxic in Alzheimer's disease

    Get PDF
    Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau, is a hallmark of Alzheimer Disease. NFT have been considered causative of neuronal death, however, recent evidence challenges this idea. Other species of tau, such as soluble misfolded, hyperphosphorylated, and mislocalized forms, are now being implicated as toxic. Here we review the data supporting soluble tau as toxic to neurons and synapses in the brain and the implications of these data for development of therapeutic strategies for Alzheimer’s disease and other tauopathies

    Long term effects of Chernobyl contamination on DNA repair function and plant resistance to different biotic and abiotic stress factors

    No full text
    corecore