Herziening van sociale zekerheid: het perspectief van flexwerkers en zelfstandigen

De idee dat individualisering de sociale solidariteit ondermijnt, is wijd verbreid.Niet alleen in het maatschappelijke discours is het bijna een gemeenplaats, ook inde sociologie vindt de stelling brede steun. Voorbeelden hiervan zijn er legio.Robert Putnam (2000) ziet gemeenschapsbesef verminderen ten gevolge van hetverzwakken van het sociale vlechtwerk in zijn inmiddels befaamde Bowling Alone.Zygmunt Baumans notie van Liquid Modernity geeft aan dat sociale institutiesniet langer richtinggevend zijn voor individuele levens, waardoor het individumeer en meer zelf vorm moet geven aan zijn leven, een leven dat fragmenteert enwaarin loyaliteiten en bindingen verzwakken (Bauman, 2001). Ook in de sfeervan de arbeid worden vergelijkbare ideeën verkondigd. Richard Sennett stelt inThe Corrosion of Character (1998) dat de moderne flexibele arbeidsmarkt waarinarbeidsrelaties vluchtig en arbeidsloopbanen zeer divers zijn geworden, de socialebanden en het klassenbesef dat hij een generatie eerder in zijn The Hidden Injuriesof Class (1972) nog tegenkwam, volledig heeft doen verdwijnen. Het gevolg vandergelijke individualiseringsprocessen is volgens velen een vergelijkbare individu‐alisering van de sociale solidariteit, leidend tot afnemende steun voor de moderneverzorgingsstaat (Giddens, 1994; Inglehart, 1997)

COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study

Background: 10 days after the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the Netherlands (on Feb 27, 2020), 55 (4%) of 1497 health-care workers in nine hospitals located in the south of the Netherlands had tested positive for SARS-CoV-2 RNA. We aimed to gain insight in possible sources of infection in health-care workers. Methods: We did a cross-sectional study at three of the nine hospitals located in the south of the Netherlands. We screened health-care workers at the participating hospitals for SARS-CoV-2 infection, based on clinical symptoms (fever or mild respiratory symptoms) in the 10 days before screening. We obtained epidemiological data through structured interviews with health-care workers and combined this information with data from whole-genome sequencing of SARS-CoV-2 in clinical samples taken from health-care workers and patients. We did an in-depth analysis of sources and modes of transmission of SARS-CoV-2 in health-care workers and patients. Findings: Between March 2 and March 12, 2020, 1796 (15%) of 12 022 health-care workers were screened, of whom 96 (5%) tested positive for SARS-CoV-2. We obtained complete and near-complete genome sequences from 50 health-care workers and ten patients. Most sequences were grouped in three clusters, with two clusters showing local circulation within the region. The noted patterns were consistent with multiple introductions into the hospitals through community-acquired infections and local amplification in the community. Interpretation: Although direct transmission in the hospitals cannot be ruled out, our data do not support widespread nosocomial transmission as the source of infection in patients or health-care workers. Funding: EU Horizon 2020 (RECoVer, VEO, and the European Joint Programme One Health METASTAVA), and the National Institute of Allergy and Infectious Diseases, National Institutes of Health

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Feeling similar or feeling unique:How men and women perceive their own sexual behaviors

The present research examined gender differences in the perceived prevalence of extradyadic sex (Study I, n = 184) and of unsafe sex (Study 2 n = 170). Two opposing hypotheses were examined: the justification hypothesis, predicting that the higher the involvement in extradyadic and unsafe sex, the higher the perceived prevalence of such behaviors would be, and the stigmatization hypothesis, predicting that the higher the level of involvement, the lower the perceived prevalence of such behaviors would be. Among men, evidence was found for the justification hypothesis, whereas among women, more evidence was found for the stigmatization hypothesis. In Study 3 (n = 574) and Study 4 (n = 637), conducted in samples representative of the general population, evidence was found that when making prevalence estimates, women thought primarily of other women and ma of other men