2 research outputs found
Megalin, proton pump inhibitors and the renināangiotensin system in healthy and pre-eclamptic placentas
Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To investigate whether PPIs lower sFlt-1 by suppressing placental renināangiotensin system (RAS) activity, we studied gene expression and protein abundance of RAS com