The effects of central cholecystokinin receptor blockade on hypothalamic-pituitary-adrenal and symptomatic responses to overnight withdrawal from alprazolam

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142739/1/Abelson-Nesse-alprazolam-BioPsych-1995.pd

Rayleigh Scattering in Rare Gas Liquids

The Rayleigh scattering length has been calculated for rare-gas liquids in the ultraviolet for the frequencies at which they luminesce. The calculations are based on the measured dielectric constants in the gas phase, except in the case of xenon for which measurements are available in the liquid. The scattering length mayplace constraints on the design of some large-scale detectors, using uv luminescence, being proposed to observe solar neutrinos and dark matter. Rayleigh scattering in mixtures of rare-gas mixtures is also discussed.Comment: 8 pages, 4 tables; This version corrects erratum in table and has expanded discussion in Section II. Accepred for publication in NIM

The ideal trefoil knot

The most tight conformation of the trefoil knot found by the SONO algorithm is presented. Structure of the set of its self-contact points is analyzed.Comment: 11 pages, 8 figure

Follow The Leader: Some Thoughts on Leadership

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68818/2/10.1177_107179199500200115.pd

Topological Andr\'e-Quillen homology for cellular commutative SS-algebras

Topological Andr\'e-Quillen homology for commutative $S$-algebras was introduced by Basterra following work of Kriz, and has been intensively studied by several authors. In this paper we discuss it as a homology theory on CW $S$-algebras and apply it to obtain results on minimal atomic $p$-local $S$-algebras which generalise those of Baker and May for $p$-local spectra and simply connected spaces. We exhibit some new examples of minimal atomic $S$-algebras.Comment: Final revision, a version will appear in Abhandlungen aus dem Mathematischen Seminar der Universitaet Hambur

Probabilistic representation for solutions of an irregular porous media type equation: the degenerate case

We consider a possibly degenerate porous media type equation over all of $\R^d$ with $d = 1$, with monotone discontinuous coefficients with linear growth and prove a probabilistic representation of its solution in terms of an associated microscopic diffusion. This equation is motivated by some singular behaviour arising in complex self-organized critical systems. The main idea consists in approximating the equation by equations with monotone non-degenerate coefficients and deriving some new analytical properties of the solution

Potential for Precision Measurement of Solar Neutrino Luminosity by HERON

Results are presented for a simulation carried out to test the precision with which a detector design (HERON) based on a superfluid helium target material should be able to measure the solar pp and Be7 fluxes. It is found that precisions of +/- 1.68% and +/- 2.97% for pp and Be7 fluxes, respectively, should be achievable in a 5-year data sample. The physics motivation to aim for these precisions is outlined as are the detector design, the methods used in the simulation and sensitivity to solar orbit eccentricity.Comment: 15 pages, 11 figure

Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple-negative breast cancer patients after neoadjuvant chemotherapy

Abstract Background For primary triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC), higher pretreatment tumor-infiltrating lymphocytes (TILs) correlates with increased pathologic complete response (pCR) rates, and improved survival. We evaluated the added prognostic value of residual disease (RD) TILs to residual cancer burden (RCB) in predicting survival post-NAC. Patients and methods We combined four TNBC NAC patient cohorts who did not achieve pCR. RD TILs were investigated for associations with recurrence-free survival (RFS), and overall survival (OS) using Cox models with stromal TILs as a continuous variable (per 10% increment). The likelihood ratio test was used to evaluate added prognostic value of RD TILs. Results A total of 375 RD TNBC samples were evaluable for TILs and RCB. The median age was 50 years, with 62% receiving anthracycline/taxane chemotherapy. The RCB class after NAC was 11%, 50%, and 39% for I, II, and III, respectively. The median RD TIL level was 20% (IQR 10–40). There was a positive correlation between RD TIL levels and CD8+ T-cell density (ρ = 0.41). TIL levels were significantly lower with increasing post-NAC tumor (P = 0.005), nodal stage (P = 0.032), but did not differ by RCB class (P = 0.84). Higher RD TILs were significantly associated with improved RFS (HR: 0.86; 95% CI 0.79–0.92; P  Conclusions TIL levels in TNBC RD are significantly associated with improved RFS and OS and add further prognostic information to RCB class, particularly in RCB class II