The Williams & Wilkins Co. Published by Elsevier Inc.
Publication date
31/05/1972
Field of study
The in vitro penetration of methotrexate (MTX) through human and hairless mouse skin was determined by two techniques. One followed tritiated MTX by scintillation counting and the other followed cold MTX by determining the inhibition of dihydrofolate reductase. Both techniques gave ample evidence for penetration of MTX through the skin of hairless mice and man