Major bleeding during negative pressure wound/V.A.C.® - therapy for postsurgical deep sternal wound infection - a critical appraisal

Negative-pressure wound therapy, commercially known as vacuum-assisted closure (V.A.C.®) therapy, has become one of the most popular (and efficacious) interim (prior to flap reconstruction) or definite methods of managing deep sternal wound infection. Complications such as profuse bleeding, which may occur during negative-pressure therapy but not necessarily due to it, are often attributed to a single factor and reported as such. However, despite the wealth of clinical experience internationally available, information regarding certain simple considerations is still lacking. Garnering information on all the factors that could possibly influence the outcome has become more difficult due to a (fortunate) decrease in the incidence of deep sternal wound infection. If more insight is to be gained from fewer clinical cases, then various potentially confounding factors should be fully disclosed before complications can be attributed to the technique itself or improvements to negative-pressure wound therapy for deep sternal wound infection can be accepted as evidence-based and the guidelines for its use adapted. The authors propose the adoption of a simple checklist in such cases

Akute Graft-versus-Host Disease (GvHD) nach Herz-Lungen-Transplantation

Wir berichten über eine 28-jährige Patientin, die aufgrund eines Ventrikelseptumdefektes (VSD) mit Eisenmengerreaktion und nachfolgender Herzinsuffizienz NYHA-Stadium IV herz-lungen-transplantiert wurde und an den Folgen einer akuten GvHD am 34. postoperativen Tag verstarb. We report on a 28 year-old woman with congenitial ventricleseptum defect and Eisenmenger-reaction who developed acute GvHD on 10th postoperative day after successfull heart lung transplantation. The patient died on the 34th postoperative day of dissociated brain death after intracerebral bleeding