Exile and Integration in the British Isles : The case of Catholic clergymen converted to Protestantism in the reign of Louis XIV

In the seventeenth and eighteenth centuries, just like the United Provinces or certain German states, the British Isles were a refuge for ex-members of the clergy who had converted at the time of the Protestant Reformation. Some joined the Church of England upon their arrival, but others converted to Calvinism.  The question of assimilation was then double for these men. On the one hand, it was linked to exile and the need to integrate into a new country whose language, customs and climate, among other factors, were different to that of the kingdom of France. On the other hand, this integration may have been trickier because of their conversion and the way the converted were perceived in the host societies. Exile was nevertheless a necessity for them. Indeed in the 1660s, Louis XIV forbade a clergyman to convert to Protestantism. Exile then was practically inevitable, his only alternative being to go into hiding.  However as ex-Catholics in their adopted land, particularly in England, known for its anti-Catholicism, they could only be regarded with great suspicion. What is then interesting is not so much to understand what they did to become assimilated in a new country and among new co-religionists, but the welcome they received and their reactions to it. The principal difficulty in studying such a question is that, among all of the ex-clergymen who converted and who took refuge in the British Isles, many left no trace, apart from their abjuration in a conformist or non-conformist Church.  The men who will appear here often published works after their conversion, whether they be conversion narratives for some of them, sermons and treatises for those who became pastors, or different writings relative to this question of assimilation. The authors cited the most here are Louis Désécotais , an ex-Capuchin, Jean-Baptiste Renoult , an ex-Cordelier, Charles Charlot d’Argenteuil , ex-regular canon and parish priest, and Jean-Baptiste Denis,  ex-priest. Thus, three principal points emerge: how did these ex-clergymen view their integration, how did they analyse the difficulties they came across, and what solutions did they find?

Statistically robust representation and comparison of mortality profiles in archaeozoology

Archaeozoological mortality profiles have been used to infer site-specific subsistence strategies. There is however no common agreement on the best way to present these profiles and confidence intervals around age class proportions. In order to deal with these issues, we propose the use of the Dirichlet distribution and present a new approach to perform age-at-death multivariate graphical comparisons. We demonstrate the efficiency of this approach using domestic sheep/goat dental remains from 10 Cardial sites (Early Neolithic) located in South France and the Iberian Peninsula. We show that the Dirichlet distribution in age-at-death analysis can be used: (i) to generate Bayesian credible intervals around each age class of a mortality profile, even when not all age classes are observed; and (ii) to create 95% kernel density contours around each age-at-death frequency distribution when multiple sites are compared using correspondence analysis. The statistical procedure we present is applicable to the analysis of any categorical count data and particularly well-suited to archaeological data (e.g. potsherds, arrow heads) where sample sizes are typically small

Statistically robust representation and comparison of mortality profiles in archaeozoology

Archaeozoological mortality profiles have been used to infer site-specific subsistence strategies. There is however no common agreement on the best way to present these profiles and confidence intervals around age class proportions. In order to deal with these issues, we propose the use of the Dirichlet distribution and present a new approach to perform age-at-death multivariate graphical comparisons. We demonstrate the efficiency of this approach using domestic sheep/goat dental remains from 10 Cardial sites (Early Neolithic) located in South France and the Iberian Peninsula. We show that the Dirichlet distribution in age-at-death analysis can be used: (i) to generate Bayesian credible intervals around each age class of a mortality profile, even when not all age classes are observed; and (ii) to create 95% kernel density contours around each age-at-death frequency distribution when multiple sites are compared using correspondence analysis. The statistical procedure we present is applicable to the analysis of any categorical count data and particularly well-suited to archaeological data (e.g. potsherds, arrow heads) where sample sizes are typically small

Interplay between Stellar Spirals and the ISM in Galactic Disks

We propose a new dynamical picture of galactic stellar and gas spirals, based on hydrodynamic simulations in a `live' stellar disk. We focus especially on spiral structures excited in a isolated galactic disk without a stellar bar. Using high-resolution, 3-dimensional N-body/SPH simulations, we found that the spiral features of the gas in galactic disks are formed by essentially different mechanisms from the galactic shock in stellar density waves. The stellar spiral arms and the interstellar matter on average corotate in a galactic potential at any radii. Unlike the stream motions in the galactic shock, the interstellar matter flows into the local potential minima with irregular motions. The flows converge to form dense gas clouds/filaments near the bottom of the stellar spirals, whose global structures resemble dust-lanes seen in late-type spiral galaxies. The stellar arms are non-steady; they are wound and stretched by the galactic shear, and thus local densities of the arm change on a time scale of ~ 100 Myrs, due to bifurcating or merging with other arms. This makes the gas spirals associated with the stellar arms non-steady. The association of dense gas clouds are eventually dissolved into inter-arm regions with non-cirucular motions. Star clusters are formed from the cold, dense gases, whose ages are less than ~30 Myrs, and they are roughly associated with the background stellar arms without a clear spatial offset between gas spiral arms and distribution of young stars.Comment: 13 pages, 12 figures, accepted by ApJ. Higher resolution of ms.pdf is available at http://d.pr/Nvjk A targzipped Supplementary movies is available at http://d.pr/TV6

Retargeting FX binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

Recent studies have generated interest in the function of human adenovirus serotype 5 (HAdV-5) hexon:  factor X (FX) binding and subsequent hepatocyte transduction and interaction with the immune system. Here, we retargeted adenovirus serotype 5 vectors, ablated for FX interaction, by replacing amino acids in hexon HVR7 with RGD-4C or inserting the peptide into the fibre HI loop. These genetic modifications in the capsid were compatible with virus assembly, and could efficiently retarget transduction of the vector via the αvβ3/5 integrin-mediated pathway, but did not alter immune recognition by pre-existing human neutralizing anti-HAdV-5 antibodies or by natural antibodies in mouse serum. Thus, FX-binding-ablated HAdV-5 can be retargeted but remain sensitive to immune-mediated attack. These findings further refine HAdV-5-based vectors for human gene therapy and inform future vector development

A Warp in Progress : H I and Radio Continuum Observations of the Spiral NGC 3145

Date of Acceptance: 16/06/2015We present VLA H I and 6 cm radio continuum observations of the spiral NGC 3145 and H I observations of its two companions, NGC 3143 and PGC 029578. In optical images NGC 3145 has stellar arms that appear to cross, forming "X"-features. Our radio continuum observations rule out shock fronts at 3 of the 4 "X"-features. In the middle-to-outer disk, the H I line-profiles of NGC 3145 are skewed. Relative to the disk, the gas in the skewed wing of the line-profiles has z-motions away from us on the approaching side of the galaxy and z-motions of about the same magnitude (about 40 km/s) towards us on the receding side. These warping motions imply that there has been a perturbation with a sizeable component perpendicular to the disk over large spatial scales. Two features in NGC 3145 have velocities indicating that they are out-of-plane tidal arms. One is an apparent branch of a main spiral arm; the velocity of the branch is 150 km/s greater than the spiral arm where they appear to intersect in projection. The other is an arm that forms 3 of the "X"-features. It differs in velocity by 56 km/s from the disk at the same projected location. Based on its SFR and H I properties, NGC 3143 is the more likely of the two companions to have interacted with NGC 3145 recently. A simple analytic model demonstrates that an encounter between NGC 3143 and NGC 3145 is a plausible explanation for the observed warping motions in NGC 3145.Peer reviewe

Methylphenidate modifies reward cue responses in adults with ADHD: An fMRI study

Attention deficit hyperactivity disorder (ADHD) has been associated with neural hyposensitivity to reward-predicting cues. Methylphenidate is widely used in the management of the disorder\u27s symptoms, but its effects on reward sensitivity in ADHD are unknown. The current study used fMRI to measure striatal responses to reward-predicting cues in adults with ADHD on and off methylphenidate and a control group, during a classical conditioning task. Responses to cued reward were also explored. Larger differences in the ventral striatum activation to reward cues versus non-reward cues were observed when the ADHD participants were on methylphenidate compared to placebo. In response to cued-reward outcome, an exploratory analysis showed methylphenidate reduced the BOLD time-series correlation between the dorsal striatum and dorsal medial prefrontal cortex. Methylphenidate\u27s therapeutic effects may be mediated by altering reward processing in individuals with ADHD