High temperature cobalt-base alloy Patent

High temperature cobalt-base alloy resistant to corrosion by liquid metals and to sublimation in vacuum environmen

Cobalt-base alloy

A microstructurally stable, high strength cobalt based alloy for use at elevated temperatures to 2125 F was developed. The alloys are particularly directed for use in stators and other low stress components in advanced gas turbines

Advanced alloy design technique: High temperature cobalt base superalloy

Advanced alloy design technique was developed for treating alloys that will have extended life in service at high temperature and intermediate temperatures. Process stabilizes microstructure of the alloy by designing it so that compound identified with embrittlement is eliminated or minimized. Design process is being used to develop both nickel and cobalt-base superalloys

Effect of variations in silicon and iron content on embrittlement of L-605 /HS-25/

Silicon and iron content effects on ductility and tensile strength of cobalt alloy after agin

Nasa developments in cobalt-base superalloys

Chemical, mechanical and physical properties of cobalt-refractory-metal superalloys for high temperature aerospace application

Development of a cobalt-tungsten ferromagnetic, high-temperature, structural alloy

Cobalt-tungsten ferromagnetic, high temperature structural alloy for rotor applications in space power generator

Short-Term Relapse Quantitation as a Fully Surrogate Endpoint for Long-Term Sustained Progression of Disability in RRMS Patients Treated with Natalizumab

Time to sustained worsening in the expanded disability status scale as the standard for evaluating the accumulation of disability has been used as a measure of clinical efficacy in many relapsing-remitting multiple sclerosis (RRMS) clinical trials. However, this measurement usually requires a large sample and long-term study to demonstrate the treatment effect. Annualized relapse rate or time to first relapse is also widely used as alternative measurements of clinical efficacy. A formal statistical validation of short-term relapse activity as a surrogate endpoint for long-term sustained progression of disability could potentially permit smaller, shorter, and less expensive clinical trials in RRMS. Four statistical validation/evaluation approaches consistently showed that relapse activity through one year of treatment serves as statistically valid surrogate endpoint for time to sustained progression of disability. The analysis demonstrates that long-term sustained progression of disability can be predicted by short-term relapse measures with 4 consistent validations of statistical approaches, including a formal statistical hypothesis test. This was demonstrated in a large phase III trial of natalizumab and showed that the beneficial clinical effect of natalizumab on sustained progression of disability at 2 years in patients with RRMS can be predicted by the total number of relapses at 1 year

Consolidated Edison Thorium Reactor-Reactor Vessel Internal Components Design

The design functions and fabrication details for internal components of the CETR are presented and pertinent analytical stress studies are summarized. Functions of the internal components include proper orientation and support for the fuel elements, proper distribution of primary coolant within the reactor vessel, and the establishment of guide channels for the control rods. (J.R.D.