Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV

A novel virus of pigs, swine hepatitis E virus (swine HEV), was recently identified and shown to be antigenically and genetically related to human HEV. In the present study, we attempted to infect specific-pathogen-free (SPF) pigs experimentally with swine HEV or with human strains of HEV. Serum samples collected from naturally infected pigs were used as the source of swine HEV. Pigs inoculated intravenously with serum samples containing swine HEV seroconverted to anti-HEV 4 to 8 weeks postinoculation, and the virus spread to an uninoculated pig. Swine HEV was detected in nasal and rectal swab materials as early as 2 weeks postinoculation and for 4 to 8 weeks thereafter. Viremia appeared 4 to 6 weeks postinoculation and lasted 1 to 3 weeks. The inoculated pigs appeared clinically normal and serum liver enzymes were not significantly elevated. In contrast, pigs were not infected when inoculated intravenously with about 105 monkey infectious doses of one of two human strains of HEV (Sar-55 or Mex-14)

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

DIGITAL ETIQUETTE IN THE STRUCTURE OF CORPORATE CULTURE OF THE MODERN ORGANIZATION: PHILOSOPHICAL CULTURAL ASPECT

It is shown that the etiquette space of corporate culture of the modern organization functions in two main dimensions, physical and virtual. Analysis of each of these dimensions and its components from the perspective of the philosophical and cultural approach gives the idea of the role and importance of the etiquette regulation in the conditions of modern corporate business environment in real and digital formats. Digital etiquette is analyzed as a three-dimensional concept, which lies at the intersection of humanitarian and technical and technological knowledge, since, on the one hand, it reflects the essential characteristics of etiquette communication in the digital environment, and on the other hand, it is developing under the conditions of a new semantic Web 3.0. and necessarily reflects its nature and functional characteristics. Digital etiquette as a new type of etiquette regulation in virtual environment is illustrated by an example of one the three directions of its development, specifically the practices of user interaction with gadgets, in which such a phenomenon of Internet addiction as phubbing is investigated

THE CORPORATE CULTURE AS A MODERN MULTI-FACTOR PHENOMENON

The corporate culture as a modern multi-factor phenomenon is considered by the example of the role of corporate culture in the new management system - human resources management system of the organization. ,4s the components of the system are highlighted and consistently considered HR-management, innovative HR management, HR-branding or employer brand, emotional management and corporate culture. It is shown that the corporate culture, as a new form of culture of the organization corresponding to the current level of social development in the new management system serves as the basis of its value, which determines the whole system of relations of administrative character, which are formed both in internal and in external environment of the company

Влияние творческих обществ на становление художественного образования города Красноярска конца XIX – начала XX века

The article considers the processes that took place in the Siberian city of Krasnoyarsk in the late 19th – early 20th centuries and were connected with the creation of cultural and educational societies. The principles of historicism and objectivity as well as the systemic approach form the key methodological basis of the research. Their application resulted in reconstruction of cultural and social life of the city and identification of the initiatives related to professional art. The use of unique archival documents and retrospective literature ensured a special focus on the history of the musical societies’ and art associations’ creation, that influenced not only the development of performing culture and exhibition activities in Krasnoyarsk, but also determined the scenario for the art education development in the city. The article concludes that the formation of cultural and educational movement in Siberia (the case of Krasnoyarsk) was discrete and took place several decades later than in Central Russia. At the same time, it was the establishment of creative unions that predetermined the scenario for the formation and development of first urban music schools and drawing classesВ статье рассматриваются процессы, происходившие в сибирском городе Красноярске в конце XIX – начале XX века, связанные с созданием культурно- просветительских обществ. Главным методологическим основанием исследования являются принципы историзма, объективности и системный подход, позволившие реконструировать культурно-социальную жизнь города и выделить инициативы, связанные с профессиональным искусством. Использование уникальных архивных документов, ретроспективной литературы позволило особое внимание уделить истории создания музыкальных обществ и художественных товариществ, которые не только повлияли на развитие исполнительской культуры и экспозиционной деятельности Красноярска, но и определили сценарий развития художественного образования города. В статье делается вывод о том, что формирование культурно- просветительского движения в Сибири (на примере Красноярска) происходило дискретно и на несколько десятилетий позже, чем в Центральной России. Вместе с тем именно создание творческих союзов предопределило сценарий формирования и развития первых городских музыкальных школ и рисовальных классо

Music Education in the Yenisei Province (end of the 19th – beginning of the 20th century)

Предметом исследования являются процессы становления профессионального музыкального образования в Енисейской губернии конца XIX – начала ХХ века. Цель работы – рассмотрение роли музыкального образования в сложении локальной системы академических традиций на примере крупнейшего российского региона. Опираясь на широкий ряд исторических источников, в том числе впервые вводимых в научный оборот, освещены технологии получения музыкальных знаний и навыков имперского этапа: обозначена роль культурно-просветительных обществ, частной педагогической практики, средней светской школы. Определенное внимание уделено созданию в 1920 году первого постоянно действующего музыкально-образовательного учреждения на Енисее – Народной консерватории. Методологически статья опирается на исторический подход. В числе ведущих выступают источниковедческий, дескриптивный и сравнительно-исторический методы. Осмысление обнаруженного эмпирического материала в социокультурологическом аспекте позволило получить новые результаты при анализе исторических событий. Сделан вывод о значении самоорганизационных процессов в становлении музыкального образования в Енисейской губернии. Антропологический подход в музыкально-краеведческом исследовании раскрывает роль личности в формировании музыкальной жизни региона, в запуске и координации самоорганизационных процессовThe subject of the research is the formation of professional music education in the Yenisei province of the late XIX – early XX century. The purpose of the work is to consider the role of music education in the formation of a local system of academic traditions on the example of the largest Russian region. Based on a wide range of historical sources, including those introduced into scientific circulation for the first time, the technologies for obtaining musical knowledge and skills of the imperial stage are highlighted and analyzed: the role of cultural and educational societies, private pedagogical practice, and the secondary secular school is indicated. Particular attention is paid to the creation in 1920 of the first permanent musical and educational institution on the Yenisei – the People’s Conservatory. Methodologically, the article is based on a historical approach. Among the leading methods are source study, descriptive and comparative historical methods. The comprehension of the discovered empirical material in the sociocultural aspect made it possible to obtain new results in the analysis of historical events. The article concludes about the importance of self-organizational processes in the development of musical education in the Yenisei province. Their action is reflected in the work of cultural and educational societies, the development of musical disciplines in the secondary secular school, and private teaching practice. The involvement of the anthropological approach in the study of local music reveals the role of the individual in shaping the musical life of the periphery, launching and coordinating self-organizational processe