Impact of biological agents on postsurgical complications in inflammatory bowel disease: A multicentre study of Geteccu

Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections

The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics

La Universidad de Alicante Universidad promotora de salud/ Universidad saludable. un reto y una oportunidad

Justificación: Dentro de la estrategia de Universidades Saludables, la Universidad de Alicante (UA) inicia un proyecto para conocer, difundir y potenciar los activos para la salud. Se plantea dotar de contenido empírico la propuesta de Morgan y Ziglio de usar el modelo de activos para la salud pública identificados por la comunidad universitaria. Objetivos: explorar la factibilidad y los retos de la aplicación de mapeos de activos para la salud en la UA con el fin de que la comunidad universitaria pueda ganar salud, calidad de vida y bienestar. Desarrollo de la experiencia: Formación de promotores de salud: • La promoción de la salud y la teoría salutogénica. • Aproximación al modelo y la estrategia de activos en salud. Enfoque Asset-Based Community Development (ABCD). • Diferencia entre recursos y activos. • Técnicas de observación y diálogo. • Técnicas mixtas: open space, TICs y mapping... • Competencias profesionales, entorno facilitador y apoyo para obtener resultados. Metodología: Lograr el mapeo de los activos en salud, sus entornos y sus estudiantes siguiendo el enfoque de John McKnight. Aplicación de “lo aprendido” en el contexto de la UA: Planificación del proyecto para el año 2014. Resultados: construcción de un mapa de activos para la salud, geolocalizado en la Universidad de Alicante. Dinamización del mapa de activos, estudiando conexiones entre activos y necesidades de la comunidad universitaria con las personas participantes, para realizar propuestas de acción futura. Difusión del mismo a través de tecnologías de la información