On Size and Shape of the Average Meson Fields in the Semibosonized Nambu & Jona-Lasinio Model

We consider a two-flavor Nambu \& Jona-Lasinio model in Hartree approximation involving scalar-isoscalar and pseudoscalar-isovector quark-quark interactions. Average meson fields are defined by minimizing the effective Euklidean action. The fermionic part of the action, which contains the full Dirac sea, is regularized within Schwinger's proper-time scheme. The meson fields are restricted to the chiral circle and to hedgehog configurations. The only parameter of the model is the constituent quark mass $M$ which simultaneously controls the regularization. We evaluate meson and quark fields self-consistently in dependence on the constituent quark mass. It is shown that the self-consistent fields do practically not depend on the constituent quark mass. This allows us to define a properly parameterized reference field which for physically relevant constituent masses can be used as a good approximation to the exactly calculated one. The reference field is chosen to have correct behaviour for small and large radii. To test the agreement between self-consistent and reference fields we calculate several observables like nucleon energy, mean square radius, axial-vector constant and delta-nucleon mass splitting in dependence on the constituent quark mass. The agreement is found to be very well. Figures available on request.Comment: 12 pages (LATEX), 3 figures available on request, report FZR 93-1

Aspects of Nucleon Compton Scattering

We consider the spin-averaged nucleon forward Compton scattering amplitude in heavy baryon chiral perturbation theory including all terms to order ${\cal O} (q^4)$. The chiral prediction for the spin-averaged forward Compton scattering amplitude is in good agreement with the data for photon energies $\omega \le 110$ MeV. We also evaluate the nucleon electric and magnetic Compton polarizabilities to this order and discuss the uncertainties of the various counter terms entering the chiral expansion of these quantities.Comment: 17 pp, TeX, 7 figures available from the authors, preprint CRN-93/5

Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells

<p>Abstract</p> <p>Background</p> <p>Heparanase facilitates the invasion and metastasis of cancer cells, and is over-expressed in many kinds of malignancies. Our studies indicated that heparanase was frequently expressed in advanced gastric cancers. The aim of this study is to determine whether silencing of heparanase expression can abolish the malignant characteristics of gastric cancer cells.</p> <p>Methods</p> <p>Three heparanase-specific small interfering RNA (siRNAs) were designed, synthesized, and transfected into cultured gastric cancer cell line SGC-7901. Heparanase expression was measured by RT-PCR, real-time quantitative PCR and Western blot. Cell proliferation was detected by MTT colorimetry and colony formation assay. The <it>in vitro </it>invasion and metastasis of cancer cells were measured by cell adhesion assay, scratch assay and matrigel invasion assay. The angiogenesis capabilities of cancer cells were measured by tube formation of endothelial cells.</p> <p>Results</p> <p>Transfection of siRNA against 1496-1514 bp of encoding regions resulted in reduced expression of heparanase, which started at 24 hrs and lasted for 120 hrs post-transfection. The siRNA-mediated silencing of heparanase suppressed the cellular proliferation of SGC-7901 cells. In addition, the <it>in vitro </it>invasion and metastasis of cancer cells were attenuated after knock-down of heparanase. Moreover, transfection of heparanase-specific siRNA attenuated the <it>in vitro </it>angiogenesis of cancer cells in a dose-dependent manner.</p> <p>Conclusions</p> <p>These results demonstrated that gene silencing of heparanase can efficiently abolish the proliferation, invasion, metastasis and angiogenesis of human gastric cancer cells <it>in vitro</it>, suggesting that heparanase-specific siRNA is of potential values as a novel therapeutic agent for human gastric cancer.</p

Magnetic field induced gap and staggered susceptibility in the S 1 2 chain [PMCu NO3 2 H2O 2]n PM pyrimidine

Single crystal magnetic susceptibility and specific heat studies of the one dimensional copper complex [PM Cu NO3 2 H2O 2]n PM pyrimidine show that it behaves like a uniform S 1 2 antiferromagnetic Heisenberg chain, characterized by the exchange parameter. Specific heat measurements in applied magnetic field, however, reveal the formation of a field induced spin excitation gap, whose magnitude depends on the magnitude and direction of the field. This behaviour is inconsistent with the ideal S 1 2 Heisenberg chain. In the low temperature region, a contribution to the susceptibility approximately proportional to 1 T is observed that strongly varies with varying direction of the magnetic field. The field induced gap and the 1 T contribution are largest for the same field direction. Previous observations of a field induced gap in the related compounds copper benzoate and Yb4As3 have been explained by the alternating g tensor and alternating Dzyaloshinkii Moriya interaction, producing an effective staggered magnetic field at the Cu and Yb ions. We apply this model to [PM Cu NO3 2 H2O 2]n and obtain a consistent quantitative explanation of the low temperature susceptibility, the field induced gap and their dependence on the magnetic field directio