Fracture toughness of AlSi10Mg alloy produced by direct energy deposition with different crack plane orientations

The fracture and tensile behaviors of the AlSi10Mg alloy processed by Direct Energy Deposition were investigated. Three-point bending fracture toughness and tensile specimens were tested at room temperature along different crack plane orientations and loading directions. Before being machined and tested, the printed samples were subjected to heat treatment at 300 °C for 2 h to relieve the residual stresses. Microstructural and fractographic analyses were performed to investigate the fracture mechanisms and the crack propagation paths for each crack orientation. Significant differences in the fracture toughness were observed among the crack plane orientations. Specimens with cracks oriented in the X-Y direction featured the highest fracture toughness values (JIc = 11.96 kJ/m2), whereas the Z-Y crack orientation (perpendicular to the printing direction) performed the lowest fracture toughness values (JIc = 8.91 kJ/m2). The anisotropy in fracture toughness is mainly related to a preferential crack propagation path along the melt pool boundaries. At melt pool boundaries, pores are preferentially placed, coarsening of the microstructure occurs and there is higher Si content, leading to that area being less ductile and less resistant to crack propagation

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Crack resistance curves of GLARE laminates by elastic compliance

The objective of this work was to study the applicability of the elastic compliance technique for crack resistance curves evaluation of commercial GLARE laminates using small SE(B) and C(T) specimens. The experimental evaluation of R-curves of 25.0 mm wide SE(B) specimens of unidirectional GLARE 1 3/2 0.3 and 50.0 mm wide C(T) specimens of bidirectional GLARE 3 5/4 0.3 was performed. Fracture toughness was measured through a recently proposed experimental methodology based on standardized specimens and elastic-plastic methodologies (J-integral and CTOD δ5), whereas crack growth was measured optically and estimated by elastic compliance. According to the results the elastic compliance technique seemed to be applicable to GLARE laminates, accurately predicting stable crack growth during the tests. © 2006 Elsevier Ltd. All rights reserved

Analysis of the Spb method for geometries where ηpl depends on a/W.

Since its proposal, the simplified Spb method has been successfully applied to the fracture toughness evaluation of metallic and polymer materials. However, some points of this methodology remain unclear, like the applicability on standardized geometries in which ηpl depends on the a/W ratio. In order to discuss this and other aspects, theoretical analyses of the Spb method were made and some experimental tests were performed. The theoretical analysis revealed that considerable differences in C(T) and SE(T) geometries could be present when the same ηpl factor for both blunt notched and pre-cracked specimens is used. To minimize these differences, the use of the most general expression of the Spb method in addition to ηpl factors provided by the standards for geometries where ηpl change with a/W is proposed. The proposed experimental methodology, based on the load separation and on ηpl factors provided by the standards, proved to be suitable for C(T) geometry, whereas for SE(T) geometry the results indicate that more research is still needed

Effect Of Loading Direction On Tensile And Fracture Behavior Of 6061 Al Alloy Produced By Binder Jetting

Binder Jetting of Al alloys can open new scenarios for the additive manufacturing of many alloys that cannot be processed by laser-based printing technologies because of the susceptibility to hot cracking (e.g., 2xxx, 6xxx and 7xxx series alloys). In this study, 6061 Al alloy samples were produced by Binder Jetting. The debinding and sintering parameters were fine-tuned and the tensile and fracture properties of the samples were assessed. Compact tension C(T) fracture specimens were notched in three different crack-plane orientations. Microstructural and fractographic analyses were performed using FE-SEM and LOM. The Al 6061-T6 alloy produced by BJ exhibited very low mechanical anisotropy. The tensile properties are in line with those reported for wrought Al 6061-T6, with a lower elongation at fracture. Brittle fracture occurred in all the crack orientations, with negligible stable crack growth and toughness values corresponding to half of those for hot-extruded Al 6061-T6 along the longitudinal direction