Characterising resistance to fatigue crack growth in adhesive bonds by measuring release of strain energy

Measurement of the energy dissipation during fatigue crack growth is used as a technique to gain more insight into the physics of the crack growth process. It is shown that the amount of energy dissipation required per unit of crack growth is determined by Gmax, whereas the total amount of energy available for crack growth in a single cycle is determined by (Δ √g)2

Інструментальна оротерапія в комплексній реабілітації дитячого церебрального паралічу

Работа посвящена вопросу о возможности использования метода прерывистой нормобарической оротерапии в комплексной реабилитации детей с разными формами церебрального паралича. Для оценки эффективности реабилитации использовали клинические данные, характеризующие динамику заболевания, полученные до и после проведения курса инструментальной оротерапии. Группа сравнения получала лишь традиционное комплексное лечение. Оценку неврологического статуса осуществляли на основании динамики уровня моторного развития. Инструментальная оротератя, основу которой составляет активация защитных сил и физиологических резервов организма больного, является эффективным немедикаментозным методом восстановительного лечения больных ДЦП путем стимуляции естественных механизмов саногенеза

Роздуми про музичну бібліографію

У статті розглянуто особливості розвитку музичної бібліографії в Україні – від доби “радянського часу” до сучасності. В даному контексті висвітлюється науковий доробок у цій царині А. І. Мухи.В статье рассмотрены особенности развития музыкальной библиографии в Украине, начиная с эпохи “советского времени” до современного этапа. В данном контексте освещено научное наследие в этой области А. И. Мухи.The peculiarities of music bibliography development in the Ukraine are investigated in the article (from epoch “Soviet Union” to modern period of time). Connected with music bibliography some books by A. Mukha are examined in this context

Manajemen Kinerja Pegawai Pada Biro Hukum Sekretariat Daerah Provinsi Sulawesi Utara

Manajemen kinerja adalah alat pengendalian manajemen perusahaan atau suatu proses yang dilakukan oleh manajer untuk memantau dan mengevaluasi kinerja karyawan. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif, dengan jumlah informan sebanyak 7 orang menggunakan teknik observasi, wawancara, dan dokumentasi melalui 3 indikator penelitian yang diperoleh. Hasil penelitian menunjukkan bahwa perencanaan kinerja di Kantor Hukum Sekretariat Sulawesi Utara masih kurang dalam intensitas kerja dan tindakan, serta kinerja dan beberapa program yang tidak terlaksana dengan baik. Sehubungan dengan evaluasi kinerja ini, sangat membantu untuk melihat sejauh mana hasil yang diharapkan sesuai dengan realitas yang ada

Образование в контексте идентификационных процессов (Субъект образования как следствие концептуальной рамки)

The available models for the prediction of fatigue crack growth in adhesive bonds rely on the similitude principle. In most cases, one of three similitude parameters based on the strain energy release rate (SERR) is used; i.e. Gmax, (Δ√G)2, or ΔG. In all cases it is usually observed that keeping the similitude parameter constant, and changing the R-ratio, results in a different crack growth rate. In this paper it is shown that this apparent ‘R-ratio’ effect is caused because the selected similitude parameter does not define a unique load cycle; a single value of the similitude parameter could correspond to infinitely many load cycles. The strain energy dissipation approach is used to show that the resistance to fatigue crack growth is related to the maximum applied load. The amount of energy available for crack growth is shown to be related to the applied cyclic work. With these relationships the R-ratio effects reported in literature can be qualitatively explained, purely in terms of the actual applied load cycle. Although it is possible that the material behaviour also depends on the R-ratio, the magnitude of these effects can only properly be determined if the applied load cycle is correctly described first.Structural Integrity & CompositesAerospace Structures & Material

Application of Machine Learning to Arterial Spin Labeling in Mild Cognitive Impairment and Alzheimer Disease

PURPOSE: To investigate whether multivariate pattern recognition analysis of arterial spin labeling (ASL) perfusion maps can be used for classification and single-subject prediction of patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) and subjects with subjective cognitive decline (SCD) after using the W score method to remove confounding effects of sex and age. MATERIALS AND METHODS: Pseudocontinuous 3.0-T ASL images were acquired in 100 patients with probable AD; 60 patients with MCI, of whom 12 remained stable, 12 were converted to a diagnosis of AD, and 36 had no follow-up; 100 subjects with SCD; and 26 healthy control subjects. The AD, MCI, and SCD groups were divided into a sex- and age-matched training set (n = 130) and an independent prediction set (n = 130). Standardized perfusion scores adjusted for age and sex (W scores) were computed per voxel for each participant. Training of a support vector machine classifier was performed with diagnostic status and perfusion maps. Discrimination maps were extracted and used for single-subject classification in the prediction set. Prediction performance was assessed with receiver operating characteristic (ROC) analysis to generate an area under the ROC curve (AUC) and sensitivity and specificity distribution. RESULTS: Single-subject diagnosis in the prediction set by using the discrimination maps yielded excellent performance for AD versus SCD (AUC, 0.96; P .05). CONCLUSION: With automated methods, age- and sex-adjusted ASL perfusion maps can be used to classify and predict diagnosis of AD, conversion of MCI to AD, stable MCI, and SCD with good to excellent accuracy and AUC values

Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multicountry study

Since 2007, mortality associated with a previously unreported haemorrhagic disease has been observed in young calves in several European countries. The syndrome, which has been named ‘bovine neonatal pancytopenia’ (BNP), is characterised by thrombocytopenia, leukocytopenia and a panmyelophthisis. A herd-level case-control study was conducted in four BNP affected countries (Belgium, France, Germany and the Netherlands) to identify herd management risk factors for BNP occurrence. Data were collected using structured face-to-face and telephone interviews of farm managers and their local veterinarians. In total, 363 case farms and 887 control farms were included in a matched multivariable conditional logistic regression analysis. Case-control status was strongly associated with the odds of herd level use of the vaccine PregSure® BVD (PregSure, Pfizer Animal Health) (matched adjusted odds ratio (OR) 107.2; 95% CI: 41.0–280.1). This was also the case for the practices of feeding calves colostrum from the calf’s own dam (OR 2.0; 95% CI: 1.1–3.4) or feeding pooled colostrum (OR 4.1; 95% CI: 1.9–8.8). Given that the study had relatively high statistical power and represented a variety of cattle production and husbandry systems, it can be concluded with some confidence that no other herd level management factors are competent causes for a sufficient cause of BNP occurrence on herd level. It is suggested that genetic characteristics of the dams and BNP calves should be the focus of further investigations aimed at identifying the currently missing component causes that together with PregSure vaccination and colostrum feeding represent a sufficient cause for occurrence of BNP in calves

The risks of using allogeneic cell lines for vaccine production: The example of Bovine Neonatal Pancytopenia

INTRODUCTION: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf's mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccine-induced alloimmune-mediated adverse events in the future are discussed

Direct and indirect effects of Johne's disease on farm and animal productivity in an Irish dairy herd

Johne's disease (JD) is caused by infection with the organism Mycobacterium avium spp. paratuberculosis, leading to chronic diarrhoea and ill thrift in adult cattle. JD is considered to adversely affect farm performance and profitability. This retrospective case study was undertaken on a single commercial dairy herd in the south west of Ireland. Animal production records were interrogated to assess the effect of JD on milk yield (total kg per lactation), somatic cell count (the geometric mean over the lactation), reasons for culling, cull price and changes in herd parity structure over time. JD groups were defined using clinical signs and test results. One control animal was matched to each case animal on parity number and year. Specific lactations (clinical, pre-clinical and test-positive only) from 1994 to 2004 were compared between JD case and control cows. A significantly lower milk yield (1259.3 kg/lactation) was noted from cows with clinical JD in comparison to their matched control group. Clinical animals had an average cull price of €516 less than animals culled without signs of clinical disease. In contrast, little effect was noted for sub-clinical infections. These direct effects of JD infections, in combination with increased culling for infertility and increasing replacement rates, had a negative impact on farm production. Results from this study provide preliminary information regarding the effects of JD status on both herd and animal-level performance in Ireland