28 research outputs found
Recommended from our members
A comparison of the forms of chronic lympholeukemia in relation to the mutational status of the genes of the immunoglobulin variable region
AIMTo compare forms of chronic lymphoid leukemia (CLL) regarding mutational status of immunoglobulin variable genes.MATERIAL AND METHODSWe have compared clinical, prognostic and immunophenotypic data obtained on 25 cases with different mutational status of IgV genes. There were 10 patients in the mutated group (median age 49.2 years, male to female ratio = 7:3), and 15 patients in unmutated group (median age 46.5, M:F = 13:2).RESULTSStatistically significant differences were noted in overall survival and CD38 expression. 5-year overall survival in unmutated group was 35%, in mutated group 80% (p = 0.07). In unmutated group CD38 was expressed on more than 50% of cells in 7 out of 14 patients, while in the mutated group in 0 of 8 patients (p = 0.007). We noted high frequency of VH1-69 gene usage in unmutated group (7 of 15 patients), while in mutated group it was used in only 1 case of 10.CONCLUSIONWe confirm the differences between groups of CLL with different mutational status of IgV genes. Highly restricted usage of VH-genes and CD38 expression possibly suggest that unmutated group also arises from antigen driven cells
Synthesis and Antimicrobial Activity of Sulfenimines Based on Pinane Hydroxythiols
The widespread presence of multidrug-resistant pathogenic microorganisms challenges the development of novel chemotype antimicrobials, insensitive to microbial tools of resistance. To date, various monoterpenoids have been shown as potential antimicrobials. Among many classes of molecules with antimicrobial activity, terpenes and terpenoids are an attractive basis for the design of antimicrobials because of their low toxicity and availability for various modifications. In this work, we report on the synthesis of sulfenimines from chiral trifluoromethylated and non-fluorinated pinane-type thiols. Final compounds were obtained with yields of up to 81%. Among the 13 sulfenimines obtained, 3 compounds were able to repress the growth of both bacteria (S. aureus, both MSSA and MRSA; P. aeruginosa) and fungi (C. albicans) with an MIC of 8–32 µg/mL. Although compounds exhibited relatively high cytotoxicity (the therapeutic index of 3), their chemotype can be used as a starter point for the development of disinfectants and antiseptics for targeting multidrug-resistant pathogens
The life history of Cyathocotyle opaca (Wisniewski, 1934) n. comb. (trematoda: Cyathocotylidae)
Morphology of geophysical fields of Terek-Caspian trough and placement patterns of oil and gas structures
Optical confinement of a laser radiation in the 3.8–4.2 μm range in a composite material containing silver nanoparticles
Prevalence of two site-specific populations of Diplostomum spp. in eye infections of rainbow trout, Salmo gairdneri Richardson, from lakes in Washington State, U.S.A.
Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity