PATTERN OF ANTIBIOTICS UTILIZATION IN NEONATAL SEPTICEMIA: A CROSS-SECTIONAL STUDY FROM RURAL TERTIARY CARE HOSPITAL WESTERN MAHARASHTRA, INDIA

Objective: To assess the quantification of use of antibiotics and to find out empiric antibiotic regimen practiced for neonatal sepsis in rural tertiary health care centre.Methods: A hospital, record based cross-sectional study was conducted in Neonatal Intensive Care Unit(NICU) at tertiary care hospital located in western Maharashtra, India. The study was planned during the year 2011-12 among 84 neonates with sepsis. Data were collected by using proforma includes demographic details, antibiotic prescriptions and relevant information.Results: Among the total 84 neonates, max, 60.71% had a history of term delivery. The proportion of early and late onset of sepsis was 47.61% and 52.38% for which total 18 antibiotics were used of which max, 88.88% were injectables. Amikacin was used in max, 78.57% neonates followed by cefotaxime, 45.23% and ampicillin, 35.71% in single or combination form respectively. Amikacin was used for max; 929 d followed by cefotaxime, 523 d and ampicillin 331 d respectively. Antibiotics used in single, double and multiple regimens were 19.04%, 46.42% and 34.52% respectively. Empiric antibiotic regimens practiced were cefotaxim+amikacin and cefotaxim+ampicillin, of which max, 80% patients were treated with the cefotaxim+amikacin antibiotic regimen. Out of 84 neonates max, 70% were improved at the time of discharge.Conclusion: Neonatal sepsis was well treated by cefotaxim+amikacin empirical injectable regimen with maximum survival

MINERAL ANALYSIS OF AVERRHOA BILIMBI L. – A POTENTIAL FRUIT

Averrhoa bilimbi L. (Oxalidaceae) is widely distributed and cultivated throughout tropical countries for their fruits. Parts such as leaves, bark, fruits are widely used in medicine as a folk remedy for many symptoms. This study provides morphological and biochemical characteristics of half-ripen bilimbi fruits. During present study physical and chemical properties of Bilimbi fruits were studied at half-ripen stage for potential benefits based on its mineral content. Phosphorus content of the fruits was higher at half-ripen stage i.e. 39 ± 1.7%, while in case of minor elements, Molybdenum is present in least amount i.e. 0.04 ± 0.05 ppm.  This Chemical studies reveals; these fruits are good source of minerals such as Potassium, Phosphorus, Nitrogen, Calcium, Magnesium and Iron suggesting its use as a potential fruit.Keywords: Averrhoa, Bilimbi, Mineral analysis, Oxalidaceae

Paraendocrine behaviour of tumours of the gastrointestinal tract with reference to human placental lactogen.

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Searching and fixating: scale-invariance vs. characteristic timescales in attentional processes

In an experiment involving semantic search, the visual movements of sample populations subjected to visual and aural input were tracked in a taskless paradigm. The probability distributions of saccades and fixations were obtained and analyzed. Scale-invariance was observed in the saccadic distributions, while the fixation distributions revealed the presence of a characteristic (attentional) time scale for literate subjects. A detailed analysis of our results suggests that saccadic eye motions are an example of Levy, rather than Brownian, dynamics.Comment: Accepted to Europhysics Letters (2011

Online Advertising An Outlook and Emerging Scenario

This paper gives an overview of online advertising, discusses the global andIndian online trends. It examines the online industry in terms of market size, segments,growth forecasts, drivers, and resistors. It also discusses about the emerging scenario ofthe industries in terms of the competitive positioning of major players and their businessmodels, strategies, and strengths, weaknesses, opportunities, and threats. The study triesto analyze the emerging models that are likely to dominate the industry.The onlineadvertising industry, which has a major dominance by Google, is likely to see a lot ofhot action in the near future. While this industry will continue to grow and be popular inthe developed world, it is likely to gain a fast growth in the emerging economies ofAsia, especially India and China.Based on the analysis, it is forecasted that the online advertising industry willalmost double from $42 billion in 2007 to$72 billion in 2012 which is a growth ofCompounded Annual Growth Rate (CAGR) 11.4%, within which North America willdominate the industry. Internet use can be expected to exceed time spent on watchingTV over period of time.The online advertising industry is expected to see a major battle with Microsoftemerging a challenger to Google‟s dominance. The web analytics tool provided bysearch engines provides an effective online marketing tool for online advertisingcompanies.Key words: Online advertising, Internet marketing, New media marketing

Role of Application Service Providers in Infrastructure Development for Web-enabled Course Administration Tool

For the effective teaching, the teacher must monitor the effectiveness and performance of the teaching methodology and techniques. For this purpose teacher can use various tools. The effective teaching can be achieved by using different elements of teaching. This paper proposes a system tools called OCAT-PA – Online Course Administration tool for Performance Analysis. This tool can be implemented as standalone system, client-server system or web enabled system. This paper focuses on the web-enabled implementation of the tool. It also focuses on the involvement of the Application Service Providers. This paper discusses the role of application service providers in the proposed system with benefits

TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death

Emerging evidence suggests that ubiquitin mediated post translational modification is a critical regulatory process involved in diverse cellular pathways including cell death. During ubiquitination, E3 ligases recognize target proteins and determine the topology of ubiquitin chains. Recruitment of E3 ligases to targets proteins under stress conditions including oxidative stress and their implication in cell death have not been systemically explored. In the present study, we characterized the role of TRIM32 as an E3 ligase in regulation of oxidative stress induced cell death. TRIM32 is ubiquitously expressed in cell lines of different origin and form cytoplasmic speckle like structures that transiently interact with mitochondria under oxidative stress conditions. The ectopic expression of TRIM32 sensitizes cell death induced by oxidative stress whereas TRIM32 knockdown shows a protective effect. The turnover of TRIM32 is enhanced during oxidative stress and its expression induces ROS generation, loss of mitochondrial transmembrane potential and decrease in complex-I activity. The pro-apoptotic effect was rescued by pan-caspase inhibitor or antioxidant treatment. E3 ligase activity of TRIM32 is essential for oxidative stress induced apoptotic cell death. Furthermore, TRIM32 decreases X-linked inhibitor of apoptosis (XIAP) level and overexpression of XIAP rescued cells from TRIM32 mediated oxidative stress and cell death. Overall, the results of this study provide the first evidence supporting the role of TRIM32 in regulating oxidative stress induced cell death, which has implications in numerous pathological conditions including cancer and neurodegeneration

Evaluation of Ponseti method in correction of congenital talipes equinovarus

Background: Congenital idiopathic clubfoot is a complex foot deformity often requires many months of treatment and frequently resulted in incomplete or defective correction by older methods. Deformity can be corrected with serial manipulation and casting with minimal or no surgery as reported by Ponseti. This study is an attempt to evaluate the effectiveness of Ponseti technique in treatment of idiopathic congenital talipes equino varus.Methods: 30 patients between age group of 01 to 24 weeks with 48 feet having congenital idiopathic clubfoot were treated using Ponseti technique. The guidelines for treatment were followed as per the Ponseti method of serial manipulation and casting at weekly intervals.Results: 43 (89.58%) cases were treated successfully by using Ponseti technique without need of extensive surgery. 42 feet required tenotomy. 38 (79.16%) feet had an excellent outcome, 5 (10.42%) feet had a fair outcome and 05 feet (10.42%) had poor outcome as measured by the Pirani scoring system. 7 (14.58%) patients had cast related complications.Conclusions: The Ponseti method is a safe, effective and reproducible method for correction of idiopathic congenital talipes equinovarus which significantly reduces the rate of extensive corrective surgeries for correction of clubfoot