3 research outputs found

    Dibromotyrosine derivatives, a maleimide, aplysamine-2 and other constituents of the marine sponge Pseudoceratina purpurea

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    A collection of the marine sponge Pseudoceratina purpurea from the Gulf of Thailand furnished aplysamine-2, two new bromotyrosine derivatives purpuroceratic acids A and B, two known bromotyrosine derivatives, 3-maleimide-5-oxime and common sponge constituents. Aplysamine-2, purpuroceratic acid A and 3-maleimide oxime were evaluated for their in vitro anticancer activity against three cancer cell lines, but only aplysamine-2 exhibited moderate dose dependent growth inhibitory effects
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