17 research outputs found
Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications
Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
Critical Role of a Survivin/TGF-β/mTORC1 Axis in IGF-I-Mediated Growth of Prostate Epithelial Cells
Low glucose dependent decrease of apoptosis and induction of autophagy in breast cancer MCF-7 cells
TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer
The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug.
The biguanide drug metformin profoundly affects cell metabolism, causing an impairment of the cell energy balance and triggering a plethora of pleiotropic effects that vary depending on the cellular or environmental context. Interestingly, a decade ago, it was observed that metformin-treated diabetic patients have a significantly lower cancer risk. Although a variety of in vivo and in vitro observations emphasising the role of metformin as anticancer drug have been reported, the underlying mechanisms are still poorly understood. Here, we discuss our current understanding of the molecular mechanisms that are perturbed by metformin treatment and that might be relevant to understand its antitumour activities. We focus on the cell-autonomous mechanisms modulating growth and death of cancer cells