Structural vulnerability of Nepalese Pagoda temples

Nepal is located in one of the most severe earthquake prone areas of the world, lying between collisions of Indian to the Eurasian plate, moving continuously, resulting in frequent devastating earthquakes within this region. Moreover, different authors refer mention that the accumulated slip deficit (central seismic gap) is likely to produce large earthquakes in the future. Also, the analysis of the available information of previous earthquakes indicates the potential damage that can occurs in unreinforced traditional masonry structures in future earthquakes. Most of the Nepalese pagoda temples were erected following very simple rules and construction details to accomplish with seismic resistance requirement, or even without any consideration for seismic resistance, during the period of Malla dynasty (1200-1768). Presently, conservation and restoration of ancient monuments are one of the major concerns in order to preserve our built heritage, transferring it to the future generations. The present paper is devoted to outline particular structural fragility characteristics in the historic Nepalese pagoda temples which affect their seismic performance. Moreover, based on the parametric analysis identified structural weaknesses/fragilities of pagoda topology, the associated traditional building technology and constructional details

MSSM A-funnel and the Galactic Center Excess: Prospects for the LHC and Direct Detection Experiments

The pseudoscalar resonance or "A-funnel" in the Minimal Supersymmetric Standard Model~(MSSM) is a widely studied framework for explaining dark matter that can yield interesting indirect detection and collider signals. The well-known Galactic Center excess (GCE) at GeV energies in the gamma ray spectrum, consistent with annihilation of a $\lesssim 40$ GeV dark matter particle, has more recently been shown to be compatible with significantly heavier masses following reanalysis of the background. In this paper, we explore the LHC and direct detection implications of interpreting the GCE in this extended mass window within the MSSM A-funnel framework. We find that compatibility with relic density, signal strength, collider constraints, and Higgs data can be simultaneously achieved with appropriate parameter choices. The compatible regions give very sharp predictions of 200-600 GeV CP-odd/even Higgs bosons at low tan$\beta$ at the LHC and spin-independent cross sections $\approx 10^{-11}$ pb at direct detection experiments. Regardless of consistency with the GCE, this study serves as a useful template of the strong correlations between indirect, direct, and LHC signatures of the MSSM A-funnel region.Comment: 32 pages and 9 figure

AN ANALYTICAL STUDY OF PRAJASTHAPAN MAHAKASHAYA ON VANDHYATWA W. S. R. TO FEMALE INFERTILITY

In Charaka samhita, among the fifty important decotives, Prajasthapan mahakashaya (fertility promoters) was introduced according its Doshaj prabhav (specific action) of the drugs and promotes strength and conceiving by removing Doshas to female reproductive system. These drugs are also having Rasayana properties, which improve the quality of all body elements. These herbs can be used all together or individually or in permutation combinations of each other on the patient's condition. In short, Prajasthapan mahakashaya can be used in all conditions involving obstruction in the path of conception and help in fixing or lead to excellence in progeny. Female Vandhyatwa (Infertility) may cause twenty Yoni vyapad (gynaecological disorders), infections, weakness, psycological factors like anxiety, depression etc., may leads disturbance in the Ritu (fertile period), Ambu (nourishment for developing the zygote), Beeja (activated ovum), Kshetra (Physiological maturity and healthy organs of reproductive system). The objective of the present study is an analytical study of Prajasthapak mahakashay on Vandhyatwa with special reference to female infertility and to analyse all ten drugs of Prajasthapan Mahakashaya to collect the information on latest studies on above mentioned factors

Color vision defects in school going children.

INTRODUCTION: Color vision defect can be observed in various diseases of optic nerve and retina and also a significant number of people suffer from the inherited condition of red and green color defect. METHODS: A cross-sectional descriptive study was designed with purposive sampling of students from various schools of Kathmandu Valley. All children were subjected to color vision evaluation using Ishihara Isochromatic color plates along with other examination to rule out any other causes for color deficiency. RESULTS: A total of 2001 students were examined, 1050 male students and 951 females with mean age of 10.35 (+/- 2.75) and 10.54 (+/- 2.72) respectively. Among the total students examined, 2.1% had some form of color vision defects. Of the male population, 3.9% had color vision defects while none of the female was found with the deficiency. CONCLUSIONS: The prevalence of color vision defect in Nepal is significant and comparable with the prevalence quoted in studies from different countries

Adverse effects including sexual problems associated with the use of selective serotonin reuptake inhibitors in a tertiary care center of Eastern Nepal

Background: Selective serotonin reuptake inhibitors (SSRIs) use has been associated with various adverse drug events, including sexual problems in recent literature.Methods: After written informed consent, remitted psychiatric patients were enrolled if they were taking an SSRI. The remitted state was ascertained by clinical assessment of a psychiatrist and reassessed with the use of self-response screening questionnaires (Beck Anxiety Inventory for anxiety, Beck Depression Inventory for depression). The self-response questionnaire “adverse drug effect (ADE) tool” was used to assess ADEs and the Arizona Sexual Experience Scale to assess sexual problems.Results: The total of 200 subjects was enrolled with 63% females. Commonly used SSRIs were escitalopram, fluoxetine, and sertraline for the common diagnosis of depression, recurrent depressive disorder, and panic disorder in this institute. The average duration of remission during the enrollment was 11.99 months (standard deviation: 12.269). The overall prevalence of adverse effects was 91.5%. The incidence of adverse effect and sexual problem were: weight gain (57%), dryness of mouth (32.5%), headache (30%), dizziness (28.5%), paresthesia (24.5%), confusion (23.5%), tremors (21.5%), irritation (20.5%) sexual dysfunction (SD) (17.2%), increase in anxiety (17%), akathisia (16%), nausea (14.5%), itchiness (14.5%), excessive sweating, (14.5%), difficulty in sleeping (10%), weight loss (6%), rash (6%), diarrhea (4%), vomiting (3%), and others (3%).Conclusion: Adverse effect (irrespective of severity) was commonly seen with SSRI use. Common adverse effects seen among remitted subjects were weight gain, dryness of mouth, headache, dizziness, paresthesia, etc. SD was other important side effect

A PROSPECTIVE COHORT STUDY ON INCIDENCE AND RISK FACTORS FOR LOW BIRTH WEIGHT AMONG INSTITUTIONAL DELIVERIES IN KATHMANDU, NEPAL

Background: Low birth weight (LBW) in developing countries are mainly due to preterm delivery and intrauterine growth retardation. Among other causes of low birth weight, maternal factors are predominant. Aim: This study aimed to identify how strongly maternal risk factors associated to low birth weight. Method and Materials: The study used cohort prospective design among 700 pregnant women attended in antenatal care outdoor patient in Paropakar Maternity Women's hospital with 6 months follow up. Results: Among 700 respondents, 23 (3%) were lost in follow up. Out of 677 mothers, 151 (22%) gave birth of LBW. The mean birth weight was 2724gm. The mean maternal weight was 48kg, height was150cm and BMI was 21.2kg/m2. The cumulative incidence of LBW in the cohort was 22%. Mothers with weight <45kg had 11 times higher risk of giving of LBW babies (RR=10.92, CI:7.90-15.08); BMI <18.5kg/m2 had 3 times higher risk of giving LBW babies (RR=3.08, CI: 2.30 - 4.12). Mothers without having past history of LBW, and preterm delivery were 0.3 times, and 0.44 times chances of giving LBW babies respectively. There are positive association of LBW with primigravida (RR=1.09), and primiparity (RR=1.41), however, it could not reach statistically significant. Conclusion: The study concluded that maternal weight <45kg is the strongest risk factor for LBW. Other maternal risk factors were weight <45kg, BMI<18.5kg/m2, mothers without past history of LBW, and preterm are also statistically significant to LBW. KEYWORDS: Low birth weight; Cohort; Hospital-based; Maternal anthropometry

Plasmonic color filter array, high performance analog to digital converter architectures and novel circuit techniques

Part I: Plasmonic color filters can be manufactured at lower cost since they can be fabricated in single lithographic process step as compared to Fabry-Perot based filters. In addition, they have narrow passband making resolving sharp features in sample spectrum possible. Due to these benefits, in this thesis, Plasmonic color filters are investigated as alternative to conventional color filters and their feasibility for spectroscopy demonstrated through reconstruction of 6 sample spectra by using a set of 20 color filters. The error in reconstructed sample spectra is less than 0.137 root mean squared error across all samples. Part II: A novel 12-bit pipelined successive approximation analog to digital converter is investigated for high speed data conversion. The design was implemented in TSMC 65nm process to demonstrate the feasibility of the architecture. Furthermore, a high dynamic range audio delta sigma modulator using pseudo-pseudo differential topology was investigated and feasibility simulated using TSMC 65nm process. In addition, various novel systems and circuit techniques including efficient calibration of feedback digital to analog converters, new boosted switch and push-pull source follower circuits were investigated to improve upon existing circuit topologies

Use of MIKE SHE for estimation of evapotranspiration in the Sprague River Basin

MIKE SHE is a fully distributed, physically-based hydrologic model that can simulate water movement over and under the Earth's surface. Evapotranspiration (ET) is one of the components of this model. MIKE SHE uses a modification of the Kristensen -Jensen (1975) method to calculate actual ET. This method is based on addition of the three evapotranspiration components – interception storage, transpiration by the plant and evaporation from the soil surface, to compute total actual evapotranspiration. The validity of the Kristensen-Jensen method has been tested on an arid region within the Sprague River subbasin of the Upper Klamath basin in southern Oregon. The model was setup on a 1,000 m by 1,000 m flat surface as a one-dimensional grid cell. There are sixteen computation layers which make three soil profile layers with varying soil properties. Meteorological data from the Pacific Northwest Cooperative Agricultural Weather Network (AgriMet) were used to setup the model. Soil physical properties were taken from the Soil Survey Geographic (SSURGO) database of the Natural Resources Conservation Service (NRCS). Values of the van Genuchten parameters for soil water retention and hydraulic conductivity as a function of soil texture from Carsel and Parrish (1988) were applied. Wetland vegetation such as duckweed and cattail, natural vegetation such as big sagebrush, ponderosa pine and juniper, and agricultural crops such as grass pasture and maize were used to test MIKE SHE evapotranspiration simulation. The length of growth stage, crop coefficient, leaf area index (LAI) and root depth values were taken from the literature. Actual crop ET rates were calculated based on AgriMet reference ET which uses the Kimberly Penman (Wright, 1982) method. The alfalfa reference ET was converted to a grass reference by multiplying by a factor of 0.833 (Jensen et al., 1990). The single crop coefficient method was used and soil stress was accounted for using the FAO 56 method (Allen et al, 1998). Simulated irrigation was applied to maize and grass to keep the root zone soil moisture close to field capacity. Crop ET rates from the MIKE SHE simulation were then compared to the AgriMet based ET rates, resulting in a comparison of Kristensen-Jensen method against the Kimberly Penman method. Both the Kristensen-Jensen and AgriMet simulation scenarios were driven by the same reference ET and the same FAO 56 basal crop coefficient. Differences are therefore a function of different methods for dealing with soil moisture stress. Results indicate that the MIKE SHE simulated evapotranspiration corresponds to the Kimberly Penman method for the duckweed and cattail wetlands species with resulting Nash and Sutcliffe (NS) efficiencies of 0.97 and 1.00, respectively. The big sagebrush, juniper, and ponderosa pine species required a soil stress correction factor for the crop coefficients and the results yielded NS efficiency values of 0.14, 0.59 and 0.68, respectively. Irrigation was automatically turned on for maize at a 20 percent soil moisture deficit to minimize the effects of water stress and the resulting NS efficiency was 0.85. For pasture, an irrigation based on average monthly water deficit for pasture in Klamath was used (Cuenca et al.,1992). This resulted in a NS efficiency of 0.77. Each crop requires unique treatment within the model. Required vegetation parameters such as crop coefficient and LAI, climatic factors such as reference ET, and soil hydraulic properties need to be based on local conditions to the extent possible. It should be noted that the MIKE SHE simulations were run in a one-dimensional mode which precluded accounting for spatial variability or lateral flow of surface or groundwater. The simulation results indicate that converting the study area into a well irrigated pasture would require application of substantial amounts of irrigation water by sprinkler or flooding. Wetlands would require even more water to flood the land, but would be well suited for development of regional habitat. Big sagebrush, juniper and ponderosa pine survive under natural conditions but experience considerable plant stress brought on by soil water deficits which limit plant production below the maximum possible growth