2 research outputs found
Thirst Perception and Drinking in Euhydrate and Dehydrated Humans
Summary: Studies on how the body senses the need to correct extracellular and intracellular volumes and ionic concentration changes is relatively scanty. The present studies were designed to determine the effect of oral distilled water (DW) and saline loads, gargling with DW and DW preload on thirst perception (TP) and drinking in euhydrate and dehydrated subjects. The subjects were healthy male volunteers between the ages of 17 and 35 years. Group A subjects were given DW or various concentrations of sodium chloride (NaCl) orally. Subjects in groups B, C and D were dehydrated for 18 hours before the experiment. Group B gargled 500ml of DW in divided volume of 50ml at five minutes interval over a period of 50 minutes. Group C gargled with DW and different concentrations of NaCl. Group D were preloaded with four volumes of DW before ad libitum DW intake. TP was rated using the Visual Analogue Scale. Results showed that in Group A, drinking DW reduced TP, suggesting that baseline TP in normal euhydrate subjects is slightly elevated. Drinking DW reduced TP more than drinking NaCl solutions. Gargling resulted in a gradual fall in TP. The decrease in TP was statistically significant after 30 minutes of gargling. Gargling with different concentrations of NaCl solutions resulted in significant reductions in TP in all the groups. There was a significant decrease in TP in the group preloaded with 1000ml of distilled water at 5 minutes of rehydration. At 20 minutes TP was abolished suggesting that approximately 1000ml of water was needed for the rehydration. These results show that baseline TP in euhydrates is elevated and that TP increases in dehydrated subjects. Gargling reduces TP, but did not abolish thirst. It is suggested that a fall in plasma osmolality due to drinking may be responsible for abolishing thirst
Thirst Perception And Drinking In Euhydrate And Dehydrate Human Subjects
Studies on how the body senses the need to correct extracellular and
intracellular volumes and ionic concentration changes is relatively
scanty. The present studies were designed to determine the effect of
oral distilled water (DW) and saline loads, gargling with DW and DW
preload on thirst perception (TP) and drinking in euhydrate and
dehydrated subjects. The subjects were healthy male volunteers between
the ages of 17 and 35 years. Group A subjects were given DW or various
concentrations of sodium chloride (NaCl) orally. Subjects in groups B,
C and D were dehydrated for 18 hours before the experiment. Group B
gargled 500ml of DW in divided volume of 50ml at five minutes interval
over a period of 50 minutes. Group C gargled with DW and different
concentrations of NaCl. Group D were preloaded with four volumes of DW
before ad libitum DW intake. TP was rated using the Visual Analogue
Scale. Results showed that in Group A, drinking DW reduced TP,
suggesting that baseline TP in normal euhydrate subjects is slightly
elevated. Drinking DW reduced TP more than drinking NaCl solutions.
Gargling resulted in a gradual fall in TP. The decrease in TP was
statistically significant after 30 minutes of gargling. Gargling with
different concentrations of NaCl solutions resulted in significant
reductions in TP in all the groups. There was a significant decrease in
TP in the group preloaded with 1000ml of distilled water at 5 minutes
of rehydration. At 20 minutes TP was abolished suggesting that
approximately 1000ml of water was needed for the rehydration. These
results show that baseline TP in euhydrates is elevated and that TP
increases in dehydrated subjects. Gargling reduces TP, but did not
abolish thirst. It is suggested that a fall in plasma osmolality due to
drinking may be responsible for abolishing thirst