Infectious endocarditis in patients with injection drug use

In the article two clinical examples of infectious endocarditis (IE) in patients with diagnosis of “fever of unknown origin” admitted to the heart disease department from the surgical one are described

Standardization of turbidimetric method study rating of platelet aggregation activity

Investigation of platelet aggregation is great importance in diagnostics of hemostasis, as well as in evaluating the effectiveness of antiplatelet therapy. The aim of this study was to standardize the most common currently turbidimetric method of platelet aggregation studies using different inducers of aggregation and their concentrations. Were examined 38 healthy donors. Represented by the standard types and calculated reference characteristics of the curves of aggregation for the laser aggregometry

Diagnosis aggregation aspirin resistance in patients after myocardial infarction in the secondary prevention of thrombotic complications

The use of acetylsalicylic acid as antiaggregant is the standard antithrombotic therapy for secondary prevention in patients with myocardial infarction. But the methods of monitoring and analysis of cause of variable efficiency of this therapy is not currently specified. The purpose of this study was to evaluate platelet aggregation activity in patients with myocardial infarction and analysis of the causes of aggregation aspirin resistance. We examined 79 patients after myocardial infarction receiving aspirin. Presented the characteristics of aggregation curves corresponding to an effective antiplatelet therapy. It was revealed that the development of aggregation aspirin resistance depends on the presence of concomitant diseases, as well as receiving beta-blockers and diuretics, and does not depend on the concentration of platelets and acetylsalicylic acid in the blood

Influence of COPD on the development of renal disease and identification of nature of kidney with specific markers

It is still not quite clear how chronic obstructive pulmonary disease (COPD) affects the urinary system. The investigation of renal disease as systemic manifestation of COPD is still relevant

Analysis of long-term prognosis indicators of dispersion mapping in patients with cardiac pathology

Purpose: to evaluate the use of indicators of dispersion mapping for the long-term prediction of adverse cardiovascular events in patients with cardiovascular diseases (CVD). The study included data of 217 people with using short recordings in dynamics throughout the year (winter, spring, summer and autumn). The 1 st group consists of 64 patients with hypertension, the 2 nd group - 44 patients with coronary heart disease, the 3rd - 30 patients with cardiomyopathy and in the 4 th group of 28 patients with coronary artery disease and diabetes mellitus. The control group consisted of 51 healthy individuals (18 men and 33 women) ranging in age from 29 to 53 years. Cardiac output was higher in the group of survivors (54,6 ± 0,5%) compared with the group with unfavorable outcome (33,8 ± 2,2%). The average values of all the indicators of dispersion mapping were higher in the group of death with the exception of heart rate index/IMM, indicating more severe violations. Noteworthy increase in 2 times the rate of alterative T wave at tT1 (Tbig) and T2 (Tmax) points. The sensitivity and specificity of the prediction of fatal outcome during 3 years of observation for record IMM > 25% was 54% and 61%