Anti-phospholipid-antibodies in patients with relapsing polychondritis

Relapsing polychondritis (RP) is an extremly rare multisystemic disease thought to be of autoimmune origin. In order to assess if RP is associated with anti-phospholipid antibodies (aPL), clinical data and sera of 21 patients with RP were collected in a multicentre study. Concentration of anti-cardiolipin antibodies (aCL) (IgG-, IgM-and IgA-isotypes), anti-phosphatidylserine-antibodies (aPS) (IgG-and IgM-isotypes) and anti-β-2-glycoprotein I-antibodies (aβ2 GPI) were measured by ELISA. In eight patients aCL were found to be elevated. One patient had elevated aPS. No patient had elevated aβ2 GPI. No patient had clinical signs and symptoms of a aPL syndrome. Interestingly, the two RP patients with the highest aPL had concomitant systemic lupus erythematosus (SLE). Therefore the presence of elevated aPL in RP is probably more closely related to an associated SLE than to RP itself. There is no convincing evidence that aPL are associated with RP

A sharp incisor tool for predator house mice back to the wild

The house mouse (Mus musculus domesticus), as a successful invasive species worldwide, has to forage a variety of resources. Subantarctic mice display among the most notable diet shift from the usual omnivorous–granivorous diet, relying on a larger proportion of terrestrial animal prey. In agreement, a recent study of their mandible morphology evidenced an evolution of their mandible shape to optimize incisor biting and hence seize preys. Here, the incisors themselves are the focus of a morphometric analysis combined with a 3D study of their internal structure, aiming at a comparison between subantarctic populations (Guillou island, Kerguelen archipelago) with a range of western European continental, commensal mice. The predatory foraging behavior of Guillou mice was indeed associated with a sharper bevel of the lower incisor, which appears as an efficient morphology for piercing prey. The incisor of these mice also displays a reduced pulp cavity, suggesting slower eruption counterbalancing a reduced abrasion on such soft food material. The dynamics of the ever‐growing incisor may thus allow adaptive incisor sculpting and participate to the success of mice in foraging diverse resources

Extensive dissolution of live pteropods in the Southern Ocean

The carbonate chemistry of the surface ocean is rapidly changing with ocean acidification, a result of human activities. In the upper layers of the Southern Ocean, aragonite—a metastable form of calcium carbonate with rapid dissolution kinetics—may become undersaturated by 2050 (ref. 2). Aragonite undersaturation is likely to affect aragonite-shelled organisms, which can dominate surface water communities in polar regions. Here we present analyses of specimens of the pteropod Limacina helicina antarctica that were extracted live from the Southern Ocean early in 2008. We sampled from the top 200m of the water column, where aragonite saturation levels were around 1, as upwelled deep water is mixed with surface water containing anthropogenic CO2. Comparing the shell structure with samples from aragonite-supersaturated regions elsewhere under a scanning electron microscope, we found severe levels of shell dissolution in the undersaturated region alone. According to laboratory incubations of intact samples with a range of aragonite saturation levels, eight days of incubation in aragonite saturation levels of 0.94– 1.12 produces equivalent levels of dissolution. As deep-water upwelling and CO2 absorption by surface waters is likely to increase as a result of human activities2,4, we conclude that upper ocean regions where aragonite-shelled organisms are affected by dissolution are likely to expand

Capillary filling with wall corrugations] Capillary filling in microchannels with wall corrugations: A comparative study of the Concus-Finn criterion by continuum, kinetic and atomistic approaches

We study the impact of wall corrugations in microchannels on the process of capillary filling by means of three broadly used methods - Computational Fluid Dynamics (CFD), Lattice-Boltzmann Equations (LBE) and Molecular Dynamics (MD). The numerical results of these approaches are compared and tested against the Concus-Finn (CF) criterion, which predicts pinning of the contact line at rectangular ridges perpendicular to flow for contact angles theta > 45. While for theta = 30, theta = 40 (no flow) and theta = 60 (flow) all methods are found to produce data consistent with the CF criterion, at theta = 50 the numerical experiments provide different results. Whilst pinning of the liquid front is observed both in the LB and CFD simulations, MD simulations show that molecular fluctuations allow front propagation even above the critical value predicted by the deterministic CF criterion, thereby introducing a sensitivity to the obstacle heigth.Comment: 25 pages, 8 figures, Langmuir in pres

Математична залежність точності верстатних пристроїв від їх ступеня гнучкості

Підвищення конкурентоспроможності продукції, що виробляється невеликими підприємствами, забезпечується шляхом скорочення витрат на проектування та виготовлення технологічної оснастки для свердлильно- фрезерно-розточувальних операцій. Це стає можливим за рахунок використання гнучких верстатних пристроїв (ВП), що мають можливість переналагодження у заданому діапазоні розмірів заготовки шляхом регулювання установлювально-затискних елементів

Landscape effects on the population dynamics of small mammal communities: A preliminary analysis of prey-resource variations

This study aims at estimating the effect of landscape composition on the availability of small mammal preys (in terms of biomass) to predators on a sectorial scale (n x 1 km2). Four study sites, representative of different stages of agriculture intensification, were selected in eastern France according to landscape composition. The population dynarnics of Microtus arvalis, Arvicola terrestris, Clethrionomys glareolus and Apodemus sp. were monitored from 1992 to 1996 by using index methods and trapping. M. arvalis and A. terrestris population biomasses were stable in landscapes with low percentage of permanent grassland. M. arvalis populations displayed greater biomass variations with sharp declines in the sites where the proportion of permanent grassland to farmland was greater than 50 %. A. terrestris populations were very unstable in one study site where the proportion of permanent grassland to farmland was greater than 85 %. Synchronic patterns between M. arvalis populations and the populations of hedgerow rodents were suspected at sites with large fluctuations of M. arvalis: every decline of the populations of hedgerow rodents was concomitant with the M. arvalis decline. These results suggest that two kinds of ecological systems in terms of prey-resource variations for mammalian predators can be distinguished: (i) stable in landscapes with lower proportion of permanent grassland, and (ii) unstable, with grassland species crashes and synchronous declines of the rodent community, in landscapes with higher proportion of permanent grassland. Moreover, the population dynamics of small mammals were asynchronous between the four sites situated at relatively short distance (some tens kilometres)L'objectif de cette étude est d'estimer l'effet de la composition du paysage sur les variations de disponibilité en biomasse de micro-mammifères pour les prédateurs, à l'échelle sectorielle (n × 1 km2), Quatre sites d'étude représentatifs d'un gradient d'intensification agricole ont été choisis dans l'est de la France en fonction de la composition du paysage. Les fluctuations de biomasses de Microtus arvalis et Arvicola terrestris (espèces prairiales), de Clethrionomys glareolus et Apodemus sp. (espèces de milieux fermés) ont été suivies de 1992 à 1996 par méthodes indiciaires et piégeage. Les synchronies entre les populations de M. arvalis et celles de rongeurs de milieux fermés ont été recherchées. Les fluctuations de biomasse de M. arvalis et A. terrestris sont stables dans les sites où la proportion de prairie permanente est la plus faible. Les populations de M. arvalis présentent les plus larges amplitudes de variation de biomasse et les déclins les plus prononcés dans les sites où la proportion de prairie permanente sur la surface agricole est supérieure à 50 %. Les populations d'A. terrestris ne sont instables que dans un site, là où la proportion de prairie permanente sur surface agricole est supérieure à 85 %. Les déclins de populations de rongeurs de milieux fermés (Clethrionomys glareolus et Apodemus sp.) sont concomitants de ceux de M. arvalis dans les sites à fortes variations de biomasse de cette dernière espèce. Ces résultats suggèrent deux types de fonctionnement, en terme de variation de disponibilité en proies pour les prédateurs: (i) stable dans les paysages à faible proportion de prairie permanente, et (ii) instable, avec des déclins prononcés et rapides des populations d'espèces prairiales, entraînant des déclins synchrones du peuplement de micro-mammifères étudié, dans les paysages à forte proportion de prairie permanente. Aucune synchronie dans les dynamiques de population de ces micro-mammifères n'est observée entre les sites d'étude, éloignés de quelques dizaines de kilomètres seulement

Clinical and ethical challenges in undertaking LIMPRINT in vulnerable populations

Background and study objective: To estimate the prevalence of CO and wounds within two vulnerable populations a male, high security prison in the East Midlands (UK) and residential and nursing homes in the UK and Australia. Methods and results: Methods for screening for chronic oedema (CO) and wounds were adapted from the main LIMPRINT methodology. Prison population. In total, 195 inmates were recruited with 22(11%) having CO. While the majority were white Caucasian (156 / 83.4%) a further 20 (10.7%) were dark skinned with 11 (5.95%) from other minority populations. Co-morbidities included 123 (63%) smokers, 22 (11%) alcohol dependant, 60 (31%) with mental health problems and 35 (18%) a history of self- harm. Only three had a current wound with 30 (16%) having had a traumatic stab wound. Residential and nursing homes (UK and Australia): In the UK, the total population available for inclusion was 189 with only 137(73%) recruited. Seventy two of the 137 (52%) suffered from CO and a further 16 (23%) had a history of cellulitis. Results from the Australian residential care facilities have been published in full. In summary, of the 37 participants 20 (54%) experienced CO with 25 (68%) having co-morbidities and 11 (30%) having a concurrent wound. Conclusion: Obtaining an accurate picture of the prevalence and impact of CO in vulnerable populations is extremely challenging due issues of access and consent. Lack of reliable data for these populations will contribute to poor service provision

Hydrophobic and metallophobic surfaces: Highly stable non-wetting inorganic surfaces based on lanthanum phosphate nanorods

Metal oxides, in general, are known to exhibit significant wettability towards water molecules because of the high feasibility of synergetic hydrogen-bonding interactions possible at the solid-water interface. Here we show that the nano sized phosphates of rare earth materials (Rare Earth Phosphates, REPs), LaPO 4 in particular, exhibit without any chemical modification, unique combination of intrinsic properties including remarkable hydrophobicity that could be retained even after exposure to extreme temperatures and harsh hydrothermal conditions. Transparent nanocoatings of LaPO 4 as well as mixture of other REPs on glass surfaces are shown to display notable hydrophobicity with water contact angle (WCA) value of 120° while sintered and polished monoliths manifested WCA greater than 105°. Significantly, these materials in the form of coatings and monoliths also exhibit complete non-wettability and inertness towards molten metals like Ag, Zn, and Al well above their melting points. These properties, coupled with their excellent chemical and thermal stability, ease of processing, machinability and their versatile photo-physical and emission properties, render LaPO 4 and other REP ceramics utility in diverse applications