13303 Prevalence of photodermatoses in the general dermatology clinic of four academic medical centers: A multicenter retrospective analysis of 1080 patients over a 10-year period

Background: Previous studies have examined the prevalence of photodermatoses among racial groups in academic institutions. Because of an insufficient amount of patients, various racial differences were not statistically significant. Objective: Assess the prevalence of photodermatoses in four academic medical centers and compare the frequency of photodermatoses among racial groups. Methods: A retrospective review of dermatology clinic medical records was performed at 4 institutions. Charts documenting a diagnosis consistent with the International Classification of Disease, Ninth and Tenth Revisions, codes related to photodermatoses between August 2006 and August 2016 were selected for further individual evaluation. A total of 9736 charts were manually reviewed and classified. Results: There were 1080 patients with photodermatoses identified: 572 (53%) African American/Black, 378 (35%) White, and 130 (12%) of other races. Statistically significant differences in the distribution between Whites and Blacks were identified for polymorphous light eruption (more common in Blacks), as well as for photoallergic contact dermatitis, phototoxic drug eruption, phytophotodermatitis, porphyria, and solar urticaria (more common in Whites). The most commonly diagnosed photodermatoses were polymorphous light eruption (total 672), photodermatitis not otherwise specified (total 189), and phototoxic drug eruption (total 73). Discussion: Comparing Blacks and Whites, our study demonstrated significantly higher proportions of polymorphous light eruption in Blacks, and higher proportions of photoallergic contact dermatitis, phototoxic drug eruptions, phytophotodermatitis, porphyrias, and solar urticaria in Whites

Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism

Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent with AD as compared with those without a family history and whether there are parent gender effects. Forty-nine 50- to 80-year-old normal subjects were examined who received clinical, neuropsychological, and 2-[18F]fluoro-2-deoxy-d-glucose–positron emission tomography examinations, including 16 subjects with a maternal (FHm) and eight with a paternal (FHp) family history of AD and 25 with no family history (FH−). FH groups were comparable for demographic and neuropsychological measures. As compared with both FH− and FHp groups, FHm subjects showed CMRglc reductions in the same regions as clinically affected AD patients, involving the posterior cingulate cortex/precuneus, parietotemporal and frontal cortices, and medial temporal lobes (P < 0.05, corrected for multiple comparisons). These effects remained significant after accounting for possible risk factors for AD, including age, gender, education, apolipoprotein E genotype, and subjective memory complaints. No CMRglc differences were found between FHp and FH− subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals