Abelian link invariants and homology

We consider the link invariants defined by the quantum Chern-Simons field theory with compact gauge group U(1) in a closed oriented 3-manifold M. The relation of the abelian link invariants with the homology group of the complement of the links is discussed. We prove that, when M is a homology sphere or when a link -in a generic manifold M- is homologically trivial, the associated observables coincide with the observables of the sphere S^3. Finally we show that the U(1) Reshetikhin-Turaev surgery invariant of the manifold M is not a function of the homology group only, nor a function of the homotopy type of M alone.Comment: 18 pages, 3 figures; to be published in Journal of Mathematical Physic

Modelling of integrated multi-energy systems : drivers, requirements, and opportunities

There is growing recognition that decarbonisation of existing uses of electricity is only ‘part of the story’ and that closer attention needs to be given to demand for energy in heating or cooling and in transport, and to all the energy vectors and infrastructures that supply the end-use demand. In this respect, concepts such as ‘multi-energy systems’ (MES) have been put forward and are gaining increasing momentum, with the aim of identifying how multiple energy systems that have been traditionally operated, planned and regulated in independent silos can be integrated to improve their collective technical, economic, and environmental performance. This paper addresses the need for modelling of MES which is capable of assessing interactions between different sectors and the energy vectors they are concerned with, so as to bring out the benefits and potential unforeseen or undesired drawbacks arising from energy systems integration. Drivers for MES modelling and the needs of different users of models are discussed, along with some of the practicalities of such modelling, including the choices to be made in respect of spatial and temporal dimensions, what these models might be used to quantify, and how they may be framed mathematically. Examples of existing MES models and tools and their capabilities, as well as of studies in which such models have been used in the authors’ own research, are provided to illustrate the general concepts discussed. Finally, challenges, opportunities and recommendations are summarised for the engagement of modellers in developing a new range of analytical capabilities that are needed to deal with the complexity of ME

Ultrasound-detected synovitis with power Doppler signal is associated with severe radiographic damage and reduced cartilage thickness in hand osteoarthritis

n/

Statistical Interparticle Potential of an Ideal Gas of Non-Abelian Anyons

We determine and study the statistical interparticle potential of an ideal system of non-Abelian Chern-Simons (NACS) particles, comparing our results with the corresponding results of an ideal gas of Abelian anyons. In the Abelian case, the statistical potential depends on the statistical parameter and it has a "quasi-bosonic" behaviour for statistical parameter in the range (0,1/2) (non-monotonic with a minimum) and a "quasi-fermionic" behaviour for statistical parameter in the range (1/2,1) (monotonically decreasing without a minimum). In the non-Abelian case the behavior of the statistical potential depends on the Chern- Simons coupling and the isospin quantum number: as a function of these two parameters, a phase diagram with quasi-bosonic, quasi-fermionic and bosonic-like regions is obtained and investigated. Finally, using the obtained expression for the statistical potential, we compute the second virial coefficient of the NACS gas, which correctly reproduces the results available in literature.Comment: 21 pages, 4 color figure

Validation of statistical clustering on TES dataset using synthetic Martian spectra

In this work we present some results concerning the analysis of Thermal Emission Spectrometer (TES) data, looking at the methane Q-branch spectral signature at 1304 cm-1. Such analysis has been enabled by producing some synthetic spectral datasets, simulating the atmospheric and surface variability observed on Mars, excluding the high latitude regions. The use of synthetic spectra is aimed to provide a better comprehension of the influence that the atmospheric state vector and its composition have on the spectral behavior. This effort is important, because the TES data are characterized by a low resolution (10 cm-1) and a significant random and systematic noise which could, in principle, give results whose quality needs to be improved. We apply statistical clustering of the synthetic spectra to evaluate the effectiveness of detecting methane, and estimating its abundance

CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype

Background: Intrahepatic Cholangiocarcinoma (iCCA) is characterized by a strong stromal reaction playing a role in tumor progression. Thymus cell antigen 1 (THY1), also called Cluster of Differentiation 90 (CD90), is a key regulator of cell–cell and cell–matrix interaction. In iCCA, CD90 has been reported to be associated with a poor prognosis. In an iCCA PDX model, we recently found that CD90 was downregulated in mice treated with the Notch γ-secretase inhibitor Crenigacestat. The study aims to investigate the role of CD90 in relation to the NOTCH pathway. Methods: THY1/CD90 gene and protein expression was evaluated in human iCCA tissues and xenograft models by qRT-PCR, immunohistochemistry, and immunofluorescence. Notch1 inhibition was achieved by siRNA. THY1/CD90 functions were investigated in xenograft models built with HuCCT1 and KKU-M213 cell lines, engineered to overexpress or knockdown THY1, respectively. Results: CD90 co-localized with EPCAM, showing its epithelial origin. In vitro, NOTCH1 silencing triggered HES1 and THY1 down-regulation. RBPJ, a critical transcriptional regulator of NOTCH signaling, exhibited putative binding sites on the THY1 promoter and bound to the latter, implying CD90 as a downstream NOTCH pathway effector. In vivo, Crenigacestat suppressed iCCA growth and reduced CD90 expression in the PDX model. In the xenograft model, Crenigacestat inhibited tumor growth of HuCCT1 cells transfected to overexpress CD90 and KKU-M213 cells constitutively expressing high levels of CD90, while not affecting the growth of HuCCT1 control cells and KKU-M213 depleted of CD90. In an iCCA cohort, patients with higher expression levels of NOTCH1/HES1/THY1 displayed a significantly shorter survival. Conclusions: iCCA patients with higher NOTCH1/HES1/THY1 expression have the worst prognosis, but they are more likely to benefit from Notch signaling inhibition. These findings represent the scientific rationale for testing NOTCH1 inhibitors in clinical trials, taking the first step toward precision medicine for iCCA

Prospect for Charge Current Neutrino Interactions Measurements at the CERN-PS

Tensions in several phenomenological models grew with experimental results on neutrino/antineutrino oscillations at Short-Baseline (SBL) and with the recent, carefully recomputed, antineutrino fluxes from nuclear reactors. At a refurbished SBL CERN-PS facility an experiment aimed to address the open issues has been proposed [1], based on the technology of imaging in ultra-pure cryogenic Liquid Argon (LAr). Motivated by this scenario a detailed study of the physics case was performed. We tackled specific physics models and we optimized the neutrino beam through a full simulation. Experimental aspects not fully covered by the LAr detection, i.e. the measurements of the lepton charge on event-by-event basis and their energy over a wide range, were also investigated. Indeed the muon leptons from Charged Current (CC) (anti-)neutrino interactions play an important role in disentangling different phenomenological scenarios provided their charge state is determined. Also, the study of muon appearance/disappearance can benefit of the large statistics of CC muon events from the primary neutrino beam. Results of our study are reported in detail in this proposal. We aim to design, construct and install two Spectrometers at "NEAR" and "FAR" sites of the SBL CERN-PS, compatible with the already proposed LAr detectors. Profiting of the large mass of the two Spectrometers their stand-alone performances have also been exploited.Comment: 70 pages, 38 figures. Proposal submitted to SPS-C, CER

Covid-19 vaccine hesitancy in systemic sclerosis

Non

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development.

Type 1 diabetes is an autoimmune disease initiated by the invasion of pancreatic islets by immune cells that selectively kill the β cells. We found that rodent and human T lymphocytes release exosomes containing the microRNAs (miRNAs) miR-142-3p, miR-142-5p, and miR-155, which can be transferred in active form to β cells favoring apoptosis. Inactivation of these miRNAs in recipient β cells prevents exosome-mediated apoptosis and protects non-obese diabetic (NOD) mice from diabetes development. Islets from protected NOD mice display higher insulin levels, lower insulitis scores, and reduced inflammation. Looking at the mechanisms underlying exosome action, we found that T lymphocyte exosomes trigger apoptosis and the expression of genes involved in chemokine signaling, including Ccl2, Ccl7, and Cxcl10, exclusively in β cells. The induction of these genes may promote the recruitment of immune cells and exacerbate β cell death during the autoimmune attack. Our data point to exosomal-miRNA transfer as a communication mode between immune and insulin-secreting cells