88 research outputs found
The effect of aminoguanidine, an inducible nitric oxide synthase inhibitor, on AlCl3 toxicity in the rat hippocampus
The presented experiment was carried out to determine the effectiveness of the inducible nitric oxide synthase inhibitor - aminoguanidine in modulating the toxicity of aluminum chloride on the nitrite levels, malondialdehyde concentration, reduced glutathione content, as well as cytochrome c oxidase activity of Wistar rats. The animals were killed 3 h and 30 days after treatment and the hippocampus was removed. The biochemical results show that aluminum acts as a pro-oxidant, while aminoguanidine exerts an antioxidant action in aluminum chloride-treated animals. We have also applied immunohistochemical techniques to identify iNOS expression after the treatment. Our data suggest that aminoguanidine can be effective in the protection of toxicity induced by aluminum chloride.U eksperimentu je određivana efikasnost inhibitora inducibilne forme azot oksid sintaze - aminogvanidina, u modulaciji toksičnosti aluminijum hlorida na nivo nitrita, koncentraciju malondialdehida, sadržaj redukovanog glutationa, kao i aktivnost citohrom c oksidaze kod Wistar pacova. Životinje su dekapitovane 3 časa i 30 dana nakon odgovarajućeg tretmana i izolovan je hipokampus. Rezultati dobijeni na biohemijskom nivou pokazuju da aluminijum deluje kao pro-oksidant, dok aminogvanidin pokazuje antioksidativno dejstvo kod životinja tretiranih aluminijum hloridom. Pored toga, korišćene su i imunohistohemijske tehnike za identifikaciju iNOS ekspresije, 3 časa nakon primene odgovarajućeg tretmana. Naši rezultati pokazuju da aminogvanidin može sprečiti toksičnost indukovanu aluminijum hloridom.nul
Trapped-Ion Quantum Simulator: Experimental Application to Nonlinear Interferometers
We show how an experimentally realized set of operations on a single trapped
ion is sufficient to simulate a wide class of Hamiltonians of a spin-1/2
particle in an external potential. This system is also able to simulate other
physical dynamics. As a demonstration, we simulate the action of an -th
order nonlinear optical beamsplitter. Two of these beamsplitters can be used to
construct an interferometer sensitive to phase shifts in one of the
interferometer beam paths. The sensitivity in determining these phase shifts
increases linearly with , and the simulation demonstrates that the use of
nonlinear beamsplitters (=2,3) enhances this sensitivity compared to the
standard quantum limit imposed by a linear beamsplitter (=1)
Uniform approximation of the distribution for the number of retransmissions of bounded documents
The effect of aminoguanidine, an inducible nitric oxide synthase inhibitor, on AlCl3 toxicity in the rat hippocampus
The presented experiment was carried out to determine the effectiveness of the inducible nitric oxide synthase inhibitor - aminoguanidine in modulating the toxicity of aluminum chloride on the nitrite levels, malondialdehyde concentration, reduced glutathione content, as well as cytochrome c oxidase activity of Wistar rats. The animals were killed 3 h and 30 days after treatment and the hippocampus was removed. The biochemical results show that aluminum acts as a pro-oxidant, while aminoguanidine exerts an antioxidant action in aluminum chloride-treated animals. We have also applied immunohistochemical techniques to identify iNOS expression after the treatment. Our data suggest that aminoguanidine can be effective in the protection of toxicity induced by aluminum chloride.U eksperimentu je određivana efikasnost inhibitora inducibilne forme azot oksid sintaze - aminogvanidina, u modulaciji toksičnosti aluminijum hlorida na nivo nitrita, koncentraciju malondialdehida, sadržaj redukovanog glutationa, kao i aktivnost citohrom c oksidaze kod Wistar pacova. Životinje su dekapitovane 3 časa i 30 dana nakon odgovarajućeg tretmana i izolovan je hipokampus. Rezultati dobijeni na biohemijskom nivou pokazuju da aluminijum deluje kao pro-oksidant, dok aminogvanidin pokazuje antioksidativno dejstvo kod životinja tretiranih aluminijum hloridom. Pored toga, korišćene su i imunohistohemijske tehnike za identifikaciju iNOS ekspresije, 3 časa nakon primene odgovarajućeg tretmana. Naši rezultati pokazuju da aminogvanidin može sprečiti toksičnost indukovanu aluminijum hloridom.nul
Collisional kinetics of non-uniform electric field, low-pressure, direct-current discharges in H
A model of the collisional kinetics of energetic hydrogen atoms, molecules,
and ions in pure H discharges is used to predict H emission
profiles and spatial distributions of emission from the cathode regions of
low-pressure, weakly-ionized discharges for comparison with a wide variety of
experiments. Positive and negative ion energy distributions are also predicted.
The model developed for spatially uniform electric fields and current densities
less than A/m is extended to non-uniform electric fields, current
densities of A/m, and electric field to gas density ratios MTd at 0.002 to 5 Torr pressure. (1 Td = V m and 1 Torr =
133 Pa) The observed far-wing Doppler broadening and spatial distribution of
the H emission is consistent with reactions among H, H,
H, and H ions, fast H atoms, and fast H molecules, and with
reflection, excitation, and attachment to fast H atoms at surfaces. The
H excitation and H formation occur principally by collisions of
fast H, fast H, and H with H. Simplifications include using a
one-dimensional geometry, a multi-beam transport model, and the average
cathode-fall electric field. The H emission is linear with current
density over eight orders of magnitude. The calculated ion energy distributions
agree satisfactorily with experiment for H and H, but are only in
qualitative agreement for H and H. The experiments successfully modeled
range from short-gap, parallel-plane glow discharges to beam-like,
electrostatic-confinement discharges.Comment: Submitted to Plasmas Sources Science and Technology 8/18/201
Status and New Data of the Geochemical Determination of the pp-Neutrino Flux by LOREX
LOREX LORandite EXperiment addresses the determination of the solar pp neutrino flux during the last four million years by exploiting the reaction 205 Tl ν e → 205 Pb e − with an incomparably low-energy threshold of 50 keV for the capture of solar neutrinos. The ratio of 205 Pb/ 205 Tl atoms in the Tl-bearing mineral lorandite provides, if corrected for the cosmic-ray induced background, the product of the flux of solar neutrinos and their capture probability by 205 Tl, averaged over the age of lorandite. To get the mean solar neutrino flux itself, four problems have to be addressed: 1 the geological age of lorandite, 2 the amount of background cosmicray-induced 205 Pb atoms which strongly depends on the erosion rate of the lorandite-bearing rocks, 3 the capture probability of solar neutrinos by 205 Tl and 4 the extraction of lorandite and the appropriate technique to "count" the small number of 205 Pb atoms in relation to the number of 205 Tl atoms. This paper summarizes the status of items 1 age and 3 neutrino capture probability and presents in detail the progress achieved most recently concerning the items 2 background/erosion and 4 "counting" of 205 Pb atoms in lorandite
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