Patient Organizations’ Funding from Pharmaceutical Companies: Is Disclosure Clear, Complete and Accessible to the Public? An Italian Survey

BACKGROUND: Many patients' and consumers' organizations accept drug industry funding to support their activities. As drug companies and patient groups move closer, disclosure become essential for transparency, and the internet could be a useful means of making sponsorship information accessible to the public. This survey aims to assess the transparency of a large group of Italian patient and consumer groups and a group of pharmaceutical companies, focusing on their websites. METHODOLOGY/PRINCIPAL FINDINGS: Patient and consumer groups were selected from those stated to be sponsored by a group of pharmaceutical companies on their websites. The websites were examined using two forms with principal (name of drug companies providing funds, amount of funding) and secondary indicators of transparency (section where sponsors are disclosed, update of sponsorship). Principal indicators were applied independently by two reviewers to the patient and consumer groups' websites. Discordances were solved by discussion. One hundred fifty-seven Italian patient and consumer groups and 17 drug companies were considered. Thirteen drug companies (76%) named at least one group funded, on their Italian websites. Of these, four (31%) indicated the activities sponsored and two (15%) the amount of funding. Of the 157 patient and consumer groups, 46 (29%) named at least one pharmaceutical company as providing funds. Three (6%) reported the amount of funding, 25 (54%) the activities funded, none the proportion of income derived from drug companies. Among the groups naming pharmaceutical company sponsors, 15 (33%) declared them in a dedicated section, five (11%) on the home page, the others in the financial report or other sections. CONCLUSIONS/SIGNIFICANCE: Disclosure of funds is scarce on Italian patient and consumer groups' websites. The levels of transparency need to be improved. Disclosure of patient and consumer groups provided with funds is frequent on Italian pharmaceutical companies' websites, but information are often not complete

Mass-loss rates of Very Massive Stars

We discuss the basic physics of hot-star winds and we provide mass-loss rates for (very) massive stars. Whilst the emphasis is on theoretical concepts and line-force modelling, we also discuss the current state of observations and empirical modelling, and address the issue of wind clumping.Comment: 36 pages, 15 figures, Book Chapter in "Very Massive Stars in the Local Universe", Springer, Ed. Jorick S. Vin

Theory and Applications of X-ray Standing Waves in Real Crystals

Theoretical aspects of x-ray standing wave method for investigation of the real structure of crystals are considered in this review paper. Starting from the general approach of the secondary radiation yield from deformed crystals this theory is applied to different concreat cases. Various models of deformed crystals like: bicrystal model, multilayer model, crystals with extended deformation field are considered in detailes. Peculiarities of x-ray standing wave behavior in different scattering geometries (Bragg, Laue) are analysed in detailes. New possibilities to solve the phase problem with x-ray standing wave method are discussed in the review. General theoretical approaches are illustrated with a big number of experimental results.Comment: 101 pages, 43 figures, 3 table

Open Issues on the Synthesis of Evolved Stellar Populations at Ultraviolet Wavelengths

In this paper we briefly review three topics that have motivated our (and others') investigations in recent years within the context of evolutionary population synthesis techniques. These are: The origin of the FUV up-turn in elliptical galaxies, the age-metallicity degeneracy, and the study of the mid-UV rest-frame spectra of distant red galaxies. We summarize some of our results and present a very preliminary application of a UV grid of theoretical spectra in the analysis of integrated properties of aged stellar populations. At the end, we concisely suggest how these topics can be tackled once the World Space Observatory enters into operation in the midst of this decade.Comment: 8 pages, 4 figures, accepted for publication in Astrophysics & Space Science, UV Universe special issu

Influence of mechanical and geometrical properties of embedded long-gauge strain sensors on the accuracy of strain measurement

In many civil and geotechnical applications it is of interest to monitor the strain deep inside the structure; consequently, it is necessary to embed the sensors into the structure's material. Construction and geotechnical materials, such as concrete and soil, can be affected by local defects, e.g. cracks, air pockets and inclusions. To monitor these materials at a structural level it is necessary to use long-gauge sensors. As the sensor has to be embedded in the host material, its presence causes perturbation of the strain field and influences the accuracy of the strain measurement. The aim of this research was to identify the critical parameters that influence the accuracy of the strain measurement, to study how these parameters affect the accuracy, and to give recommendations for sensor users. The study was based on finite element analysis and all involved materials were assumed to have the MöhrCoulomb elastic, perfectly plastic behavior. A suitability of the numerical model for the analysis was verified using the experimental results of two cases reported in the literature and one on-site application. The study revealed that the most important parameters that influence the accuracy of the strain measurement are the goodness of interaction (strain transfer) between the host material and the anchor pieces of the sensor, the ratio between equivalent Young's modulus of the sensor and the Young's modulus of the host material, the radius of the anchor piece and the gauge length. The numerical model and parametric study are presented in detail along with practical recommendations. © 2012 IOP Publishing Ltd.The authors would like to thank the Spanish Ministry of Education, with support received under the National Program for Mobility of Researchers (O.M. EDU/1456/2010, ref. PR2010-0293) which enabled the joint work that made this study possible. The Streicker Bridge project was realized with help of Turner Construction Co., HNTB, AG Construction Corp., Vollers Excavating & Constr., SMARTEC SA, Micron Optics, Princeton Facilities, and staff and students of CEE department of Princeton University.Calderón García, PA.; Glisic, B. (2012). Influence of mechanical and geometrical properties of embedded long-gauge strain sensors on the accuracy of strain measurement. Measurement Science and Technology. (23):1-15. https://doi.org/10.1088/0957-0233/23/6/065604S11523Glišić, B., & Inaudi, D. (2007). Fibre Optic Methods for Structural Health Monitoring. doi:10.1002/9780470517819Ansari, F. (2007). Practical Implementation of Optical Fiber Sensors in Civil Structural Health Monitoring. Journal of Intelligent Material Systems and Structures, 18(8), 879-889. doi:10.1177/1045389x06075760Li, H.-N., Zhou, G.-D., Ren, L., & Li, D.-S. (2009). Strain Transfer Coefficient Analyses for Embedded Fiber Bragg Grating Sensors in Different Host Materials. Journal of Engineering Mechanics, 135(12), 1343-1353. doi:10.1061/(asce)0733-9399(2009)135:12(1343)Torres, B., Payá-Zaforteza, I., Calderón, P. A., & Adam, J. M. (2011). Analysis of the strain transfer in a new FBG sensor for Structural Health Monitoring. Engineering Structures, 33(2), 539-548. doi:10.1016/j.engstruct.2010.11.012Kesavan, K., Ravisankar, K., Parivallal, S., Sreeshylam, P., & Sridhar, S. (2010). Experimental studies on fiber optic sensors embedded in concrete. Measurement, 43(2), 157-163. doi:10.1016/j.measurement.2009.08.010Azenha, M., Faria, R., & Ferreira, D. (2009). Identification of early-age concrete temperatures and strains: Monitoring and numerical simulation. Cement and Concrete Composites, 31(6), 369-378. doi:10.1016/j.cemconcomp.2009.03.004Glisic, B. (2011). Influence of the gauge length on the accuracy of long-gauge sensors employed in monitoring of prismatic beams. Measurement Science and Technology, 22(3), 035206. doi:10.1088/0957-0233/22/3/035206Leng, J. S., Winter, D., Barnes, R. A., Mays, G. C., & Fernando, G. F. (2006). Structural health monitoring of concrete cylinders using protected fibre optic sensors. Smart Materials and Structures, 15(2), 302-308. doi:10.1088/0964-1726/15/2/009Calderón, P. A., Adam, J. M., Ivorra, S., Pallarés, F. J., & Giménez, E. (2009). Design strength of axially loaded RC columns strengthened by steel caging. Materials & Design, 30(10), 4069-4080. doi:10.1016/j.matdes.2009.05.014Adam, J. M., Ivorra, S., Pallarés, F. J., Giménez, E., & Calderón, P. A. (2009). Axially loaded RC columns strengthened by steel caging. Finite element modelling. Construction and Building Materials, 23(6), 2265-2276. doi:10.1016/j.conbuildmat.2008.11.014Adam, J. M., Ivorra, S., Pallares, F. J., Jiménez, E., & Calderón, P. A. (2008). Column–joint assembly in RC columns strengthened by steel caging. Proceedings of the Institution of Civil Engineers - Structures and Buildings, 161(6), 337-348. doi:10.1680/stbu.2008.161.6.337Adam, J. M., Ivorra, S., Pallares, F. J., Giménez, E., & Calderón, P. A. (2009). Axially loaded RC columns strengthened by steel cages. Proceedings of the Institution of Civil Engineers - Structures and Buildings, 162(3), 199-208. doi:10.1680/stbu.2009.162.3.199Johansson, M., & Gylltoft, K. (2001). Structural behavior of slender circular steel-concrete composite columns under various means of load application. Steel and Composite Structures, 1(4), 393-410. doi:10.12989/scs.2001.1.4.393Johansson, M., & Gylltoft, K. (2002). Mechanical Behavior of Circular Steel–Concrete Composite Stub Columns. Journal of Structural Engineering, 128(8), 1073-1081. doi:10.1061/(asce)0733-9445(2002)128:8(1073

Autopsy as a site and mode of inquiry: de/composing the ghoulish hu/man gaze

For centuries the autopsy has been a key technology in Western culture for generating clinical/medical as well as cultural knowledge about bodies. This article hails the anato-medical autopsy as a generative trope and apparatus in reconfiguring Western humanist knowledge of bodies and bodies of knowledge and takes up the possibilities of working with the concept of autopsy in disrupting qualitative research methodology. In doing so, the article outlines and returns (to) a series of research-creation experiments assembled at an academic conference, which engaged with the challenges for social science knowledge laid out by Law’s (2004) After Method book. Our research-creation experiments centred autopsy as a theoretical-methodological gaze and apparatus for de-composing qualitative research methodology by engaging with post-humanist and new material feminist thinking

The deuteron: structure and form factors

A brief review of the history of the discovery of the deuteron in provided. The current status of both experiment and theory for the elastic electron scattering is then presented.Comment: 80 pages, 33 figures, submited to Advances in Nuclear Physic

The ethics of psychopharmacological research in legal minors

Research in psychopharmacology for children and adolescents is fraught with ethical problems and tensions. This has practical consequences as it leads to a paucity of the research that is essential to support the treatment of this vulnerable group. In this article, we will discuss some of the ethical issues which are relevant to such research, and explore their implications for both research and standard care. We suggest that finding a way forward requires a willingness to acknowledge and discuss the inherent conflicts between the ethical principles involved. Furthermore, in order to facilitate more, ethically sound psychopharmacology research in children and adolescents, we suggest more ethical analysis, empirical ethics research and ethics input built into psychopharmacological research design

Patterns of dog gastrointestinal contractile activity monitored in vivo with extraluminal force transducers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44363/1/10620_2005_Article_BF02233437.pd

Uncertainties in the Anti-neutrino Production at Nuclear Reactors

Anti-neutrino emission rates from nuclear reactors are determined from thermal power measurements and fission rate calculations. The uncertainties in these quantities for commercial power plants and their impact on the calculated interaction rates in electron anti-neutrino detectors is examined. We discuss reactor-to-reactor correlations between the leading uncertainties and their relevance to reactor anti-neutrino experiments.Comment: Submitted to Phys Rev