Serotonergic Modulation of Conditioned Fear

Conditioned fear plays a key role in anxiety disorders as well as depression and other neuropsychiatric conditions. Understanding how neuromodulators drive the associated learning and memory processes, including memory consolidation, retrieval/expression, and extinction (recall), is essential in the understanding of (individual differences in vulnerability to) these disorders and their treatment. The human and rodent studies I review here together reveal, amongst others, that acute selective serotonin reuptake inhibitor (SSRI) treatment facilitates fear conditioning, reduces contextual fear, and increases cued fear, chronic SSRI treatment reduces both contextual and cued fear, 5-HT(1A) receptors inhibit the acquisition and expression of contextual fear, 5-HT(2A) receptors facilitates the consolidation of cued and contextual fear, inactivation of 5-HT(2C) receptors facilitate the retrieval of cued fear memory, the 5-HT(3) receptor mediates contextual fear, genetically induced increases in serotonin levels are associated with increased fear conditioning, impaired cued fear extinction, or impaired extinction recall, and that genetically induced 5-HT depletion increases fear conditioning and contextual fear. Several explanations are presented to reconcile seemingly paradoxical relationships between serotonin levels and conditioned fear

Abusive supervision, public service motivation, and employee deviance: The moderating role of employment sector

Purpose – The purpose of this paper is to examine abusive supervision and public service motivation (PSM) as antecedents of deviant workplace behaviours. Design/methodology/approach – The study was conducted in a cross-sectional research design with survey data from 150 employees in the public, private and non-profit sector in Germany and the USA. Findings – Abusive supervision is positively associated with employee deviance, whereas PSM is negatively related to deviant behaviours. The employment sector moderates the negative relationship between PSM and employee deviance such that this relationship is stronger in the public and non-profit sector. Research limitations/implications – Limitations arise from the convenience sampling approach and the cross-sectional nature of the dataset. Practical implications – Human resource managers should consider behavioural integrity in the attraction, selection and training of both supervisors and subordinates. Private organisations can address the needs of strongly public service motivated employees by integrating associated goals and values into organisational missions and policies. Originality/value – This is the first study to introduce PSM into research on employee deviance. It shows that a pro-social motivation can drive anti-social behaviours when employees with high levels of PSM are members of profit-seeking organisations. Keywords Counterproductive work behaviour, Dark side of leadership, Destructive leadership, Person-organisation fit Paper type Research pape

Analytical modeling of HSUPA-enabled UMTS networks for capacity planning

In recent years, mobile communication networks have experienced significant evolution. The 3G mobile communication system, UMTS, employs WCDMA as the air interface standard, which leads to quite different mobile network planning and dimensioning processes compared with 2G systems. The UMTS system capacity is limited by the received interference at NodeBs due to the unique features of WCDMA, which is denoted as `soft capacity'. Consequently, the key challenge in UMTS radio network planning has been shifted from channel allocation in the channelized 2G systems to blocking and outage probabilities computation under the `cell breathing' effects which are due to the relationship between network coverage and capacity. The interference characterization, especially for the other-cell interference, is one of the most important components in 3G mobile networks planning. This monograph firstly investigates the system behavior in the operation of UMTS uplink, and develops the analytic techniques to model interference and system load as fully-characterized random variables, which can be directly applicable to the performance modeling of such networks. When the analysis progresses from single-cell scenario to multi-cell scenario, as the target SIR oriented power control mechanism is employed for maximum capacity, more sophisticated system operation, `feedback behavior', has emerged, as the interference levels at different cells depend on each other. Such behaviors are also captured into the constructed interference model by iterative and approximation approaches. The models are then extended to cater for the features of the newly introduced HSUPA, which provides enhanced dedicated channels for the packet switched data services such that much higher bandwidth can be achieved for best-effort elastic traffic, which allows network operators to cope with the coexistence of both circuit-switched and packet-switched traffic and guarantee the QoS requirements. During the derivation, we consider various propagation models, traffic models, resource allocation schemes for many possible scenarios, each of which may lead to different analytical models. All the suggested models are validated with either Monte-Carlo simulations or discrete event simulations, where excellent matches between results are always achieved. Furthermore, this monograph studies the optimization-based resource allocation strategies in the UMTS uplink with integrated QoS/best-effort traffic. Optimization techniques, both linear-programming based and non-linear-programming based, are used to determine how much resource should be assigned to each enhanced uplink user in the multi-cell environment where each NodeB possesses full knowledge of the whole network. The system performance under such resource allocation schemes are analyzed and compared via Monte-Carlo simulations, which verifies that the proposed framework may serve as a good estimation and optimal reference to study how systems perform for network operators

Anatomical organization of the cerebrum of the praying mantis <em>Hierodula membranacea</em>

\ua9 2024 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.Many predatory animals, such as the praying mantis, use vision for prey detection and capture. Mantises are known in particular for their capability to estimate distances to prey by stereoscopic vision. While the initial visual processing centers have been extensively documented, we lack knowledge on the architecture of central brain regions, pivotal for sensory motor transformation and higher brain functions. To close this gap, we provide a three-dimensional (3D) reconstruction of the central brain of the Asian mantis, Hierodula membranacea. The atlas facilitates in-depth analysis of neuron ramification regions and aides in elucidating potential neuronal pathways. We integrated seven 3D-reconstructed visual interneurons into the atlas. In total, 42 distinct neuropils of the cerebrum were reconstructed based on synapsin-immunolabeled whole-mount brains. Backfills from the antenna and maxillary palps, as well as immunolabeling of γ-aminobutyric acid (GABA) and tyrosine hydroxylase (TH), further substantiate the identification and boundaries of brain areas. The composition and internal organization of the neuropils were compared to the anatomical organization of the brain of the fruit fly (Drosophila melanogaster) and the two available brain atlases of Polyneoptera—the desert locust (Schistocerca gregaria) and the Madeira cockroach (Rhyparobia maderae). This study paves the way for detailed analyses of neuronal circuitry and promotes cross-species brain comparisons. We discuss differences in brain organization between holometabolous and polyneopteran insects. Identification of ramification sites of the visual neurons integrated into the atlas supports previous claims about homologous structures in the optic lobes of flies and mantises

A Distinct Layer of the Medulla Integrates Sky Compass Signals in the Brain of an Insect

Mass migration of desert locusts is a common phenomenon in North Africa and the Middle East but how these insects navigate is still poorly understood. Laboratory studies suggest that locusts are able to exploit the sky polarization pattern as a navigational cue. Like other insects locusts detect polarized light through a specialized dorsal rim area (DRA) of the eye. Polarization signals are transmitted through the optic lobe to the anterior optic tubercle (AOTu) and, finally, to the central complex in the brain. Whereas neurons of the AOTu integrate sky polarization and chromatic cues in a daytime dependent manner, the central complex holds a topographic representation of azimuthal directions suggesting a role as an internal sky compass. To understand further the integration of sky compass cues we studied polarization-sensitive (POL) neurons in the medulla that may be intercalated between DRA photoreceptors and AOTu neurons. Five types of POL-neuron were characterized and four of these in multiple recordings. All neurons had wide arborizations in medulla layer 4 and most, additionally, in the dorsal rim area of the medulla and in the accessory medulla, the presumed circadian clock. The neurons showed type-specific orientational tuning to zenithal polarized light and azimuth tuning to unpolarized green and UV light spots. In contrast to neurons of the AOTu, we found no evidence for color opponency and daytime dependent adjustment of sky compass signals. Therefore, medulla layer 4 is a distinct stage in the integration of sky compass signals that precedes the time-compensated integration of celestial cues in the AOTu

Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis

The short allelic variant of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) has been associated with the etiology of major depression by interaction with early life stress (ELS). Furthermore, 5-HTTLPR has been associated with abnormal functioning of the stress-responsive hypothalamo-pituitary-adrenal (HPA) axis. Here, we examined if, and at what level, the HPA-axis is affected in an animal model for ELS × 5-HTTLPR interactions. Heterozygous and homozygous 5-HTT knockout rats and their wild-type littermates were exposed daily at postnatal days 2–14 to 3 h of maternal separation. When grown to adulthood, plasma levels of adrenocorticotropic hormone (ACTH), and the major rat glucocorticoid, corticosterone (CORT), were measured. Furthermore, the gene expression of key HPA-axis players at the level of the hypothalamus, pituitary and adrenal glands was assessed. No 5-HTT genotype × ELS interaction effects on gene expression were observed at the level of the hypothalamus or pituitary. However, we found significant 5-HTT genotype × ELS interaction effects for plasma CORT levels and adrenal mRNA levels of the ACTH receptor, such that 5-HTT deficiency was associated under control conditions with increased, but after ELS with decreased basal HPA-axis activity. With the use of an in vitro adrenal assay, naïve 5-HTT knockout rats were furthermore shown to display increased adrenal ACTH sensitivity. Therefore, we conclude that basal HPA-axis activity is affected by the interaction of 5- HTT genotype and ELS, and is programmed, within the axis itself, predominantly at the level of the adrenal gland. This study therefore emphasizes the importance of the adrenal gland for HPA-related psychiatric disorders

The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration

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Haptic identification of objects using a modular soft robotic gripper

This work presents a soft hand capable of robustly grasping and identifying objects based on internal state measurements. A highly compliant hand allows for intrinsic robustness to grasping uncertainty, but the specific configuration of the hand and object is not known, leaving undetermined if a grasp was successful in picking up the right object. A soft finger was adapted and combined to form a three finger gripper that can easily be attached to existing robots, for example, to the wrist of the Baxter robot. Resistive bend sensors were added within each finger to provide a configuration estimate sufficient for distinguishing between a set of objects. With one data point from each finger, the object grasped by the gripper can be identified. A clustering algorithm to find the correspondence for each grasped object is presented for both enveloping grasps and pinch grasps. This hand is a first step towards robust proprioceptive soft grasping

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes : A systematic review and meta-analyses of animal studies

Funding Information: This work was supported by a ZonMw grant (MKMD project; ID 114024127 ) awarded to JO & AR, and a grant awarded to JH from the Donders Institute for Brain, Cognition and Behavior . Funding bodies had no role in study design, data collection, data analysis, data interpretation, or the writing of the report.Peer reviewedPublisher PD