52 research outputs found
The Inhibition of Acetylcholinesterase by Organophosphorus Compounds and its Reversal [ Abridged
No full textThe importance of the position of the quaternary nitrogen atom in the molecule of certain compounds to their ability to react with true cholinesterase and pseudocholinesterase
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Blood levels, urinary excretion and potential toxicity of N, N′-trimethylenebis (pyridinium 4-aldoxime) dichloride (TMB-4) in healthy man following intramuscular injection of the oxime
No full textPharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions
No full text1This was a multi-centre, placebo controlled, randomized, dose-escalating design study in which five dosing regimens of 619C89/placebo were evaluated in 48 stroke patients. Loading infusions of 0.5, 1, 1.5, 2 and 2.5 mg kg−1 over 1 h were followed by respective maintenance infusions of 0.25, 0.5, 0.75, 1 and 1.25 mg kg−1 over 30 min at 8 hourly intervals for 3 days
Antidotische Wirkung von Pyridin-2-aldoximdodecyljodid bei der Trikresylphosphatl�hmung
No full textMEASUREMENT OF THE RATE OF ACETYLCHOLINE DIFFUSION THROUGH A BRAIN SLICE AND ITS SIGNIFICANCE IN STUDIES OF THE CELLULAR DISTRIBUTION OF ACETYLCHOLINESTERASE
No full textAntidotal effects of pyridinium- and imidazolium salts on soman and paraoxon poisoning in mice
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