Electron Cooling System Development

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Acoustic Emissions Applications on the Nasa Space Station

The space station is an internally pressurized container carrying inside it everything necessary to support human life in space. Since the shell of the space station contains numerous penetrations it will always be susceptible to seal failure, and when in orbit it will also be exposed to impacts from meteoroids and debris. Although designed to minimize the effects of impacts, damage which breaches the shell threatens the lives of the astronauts. Even small penetrations may require an unacceptable amount of time and effort to locate if a manual scan is necessary. Monitoring under these conditions is best done with acoustic emission (AE), which can be configured as a continuous, remote, and operator-independent monitoring system capable of detecting and locating large and small damage sources

Neutron Knockout Reactions

This work was supported by the National Science Foundation Grant NSF PHY 81-14339 and by Indiana Universit

The IUCF Cooler Project

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Neutron Knockout Reactions

This work was supported by the National Science Foundation Grant NSF PHY 78-22774 A02 & A03 and by Indiana Universit

Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation.

FGF applied as a single growth factor to quiescent mouse fibroblasts induces a round of DNA replication, however continuous stimulation results in arrest in the G1 phase of the next cell cycle. We hypothesized that FGF stimulation induces the establishment of cell memory, which prevents the proliferative response to repeated or continuous FGF application. When a 2-5 day quiescence period was introduced between primary and repeated FGF treatments, fibroblasts failed to efficiently replicate in response to secondary FGF application. The establishment of “FGF memory” during the first FGF stimulation did not require DNA synthesis, but was dependent on the activity of FGF receptors, MEK, p38 MAPK and NFκB signaling, and protein synthesis. While secondary stimulation resulted in strongly decreased replication rate, we did not observe any attenuation of morphological changes, Erk1/2 phosphorylation and cyclin D1 induction. However, secondary FGF stimulation failed to induce the expression of cyclin A, which is critical for the progression from G1 to S phase. Treatment of cells with a broad range histone deacetylase inhibitor during the primary FGF stimulation rescued the proliferative response to the secondary FGF treatment suggesting that the establishment of “FGF memory” may be based on epigenetic changes. We suggest that “FGF memory” can prevent the hyperplastic response to cell damage and inflammation, which are associated with an enhanced FGF production and secretion. “FGF memory” may present a natural obstacle to the efficient application of recombinant FGFs for the treament of ulcers, ischemias and wounds

IUCF High Intensity Polarized Ion Source

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Measurements of S and P-A Using the 12-C(p,p'y) Reaction at 150 MeV

This work was supported by the National Science Foundation Grant NSF PHY 81-14339 and by Indiana Universit

(d,n) Reaction Studies at 80 MeV

This research was sponsored by the National Science Foundation Grant NSF PHy 87-1440