High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

The common gamma (?c)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modulator which impacts the generation, maturation and activity of many cell types of the innate, as well as the adaptive immune system, including natural killer (NK) and CD8+ T cells. Using a new series of transgenic mice, we analyzed the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes, i.e. soluble monomer or complexed to its specific receptor a (Ra)-chain. We have identified distinct effects on selected IL15-responsive populations. While CD8+ T cells required complexed forms of IL15/IL15Ra for full functionality, mature NK populations were rescued in an IL15/IL15Ra-deficient environment by high levels of CD11c-restricted IL15. These IL15-conditions were sufficient to limit tumor formation in a lung metastasis model indicating that the NK cell populations were fully functional. These data underline the potential of "free" IL15 in the absence of Ra-complex as a powerful and specific immuno-modulator, which may be beneficial where selective immune-activation is desired

Virtual Try-On : Topics in Realistic, Individualized Dressing in Virtual Reality

In the course of the project Virtual Try-On new VR technologies have been developed, which form the basis for a realistic, three dimensional, (real-time) simulation and visualization of individualized garments put on by virtual counterparts of real customers. To provide this cloning and dressing of people in VR, a complete process chain is being build up starting with the touch-less 3-dimensional scanning of the human body up to a photo-realistic 3-dimensional presentation of the virtual customer dressed in the chosen pieces of clothing. The emerging platform for interactive selection and configuration of virtual garments, the "virtual shop", will be accessible in real fashion boutiques as well as over the internet, thereby supplementing the conventional distribution channels

Virtual Try-On Topics in Realistic, Individualized Dressing in Virtual Reality

In the course of the project Virtual Try-On new VR technologies have been developed, which form the basis for a realistic, three dimensional, (real-time) simulation and visualization of individualized garments put on by virtual counterparts of real customers. To provide this cloning and dressing of people in VR, a complete process chain is being build up starting with the touchless 3-dimensional scanning of the human body up to a photo-realistic 3-dimensional presentation of the virtual customer dressed in the chosen pieces of clothing. The emerging platform for interactive selection and configuration of virtual garments, the „virtual shop“, will be accessible in real fashion boutiques as well as over the internet, thereby supplementing the conventional distribution channels. 1