Neutrino Cooled disk in GRB central engine

At the extreme densities and temperatures typical of the central engine of GRBs, the accreting torus is cooled mainly by advection and by neutrino emission. The latter process is dominated by electron and positron capture onto nucleons ($\beta$ reactions). We calculate the reaction rates and the nuclear composition of matter, assuming that the torus consists of helium, eletron-positron pairs, free neutrons and protons. After determining the equation of state and solving for the disk structure for a given initial accretion rate, we subsequently follow its time evolution. We find that, for accretion rates of the order of $10 M_{\odot}$/s, likely typical for the early stages of the accretion event, the disk becomes unstable, giving rise to variable energy output. This instability may play an important role for producing internal shocks.Comment: 4 pages, 3 figures; to appear in Proceedings of the Conference "Astrophysical Sources of High Energy Particles and Radiation", held in Torun, Poland, 20-24 June 200

Prospects for obtaining an r-process from Gamma Ray Burst Disk Winds

We discuss the possibility that r-process nucleosynthesis may occur in the winds from gamma ray burst accretion disks. This can happen if the temperature of the disk is sufficiently high that electron antineutrinos are trapped as well as neutrinos. This implies accretion disks with greater than a solar mass per second accretion rate, although lower accretion rates with higher black hole spin parameters may provide viable environments as well. Additionally, the outflow from the disk must either have relatively low entropy, e.g. around s = 10, or the initial acceleration of the wind must be slow enough that it is neutrino and antineutrino capture as opposed to electron and positron capture that sets the electron fraction.Comment: 8 pages, submitted to Nucl. Phys. A as part of the Nuclei in Cosmos 8 proceeding

Role of GALNT2 in the modulation of ENPP1 expression, insulin signaling and action: GALNT2: A novel modulator of insulin signaling

Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling and action. Understanding the mechanisms underlying ENPP1 expression may help unravel molecular mechanisms of insulin resistance. Recent data suggest a role of ENPP1-3'untraslated region (UTR), in controlling ENPP1 expression. We sought to identify trans-acting ENPP1-3'UTR binding proteins, and investigate their role on insulin signaling. By RNA pull-down, 49 proteins bound to ENPP1-3'UTR RNA were identified by mass spectrometry (MS). Among these, in silico analysis of genome wide association studies and expression profile datasets pointed to N-acetylgalactosaminyltransferase 2 gene (GALNT2) for subsequent investigations. Gene expression levels were evaluated by RT-PCR. Protein expression levels, IRS-1 and Akt phosphorylation were evaluated by Western blot. Insulin receptor (IR) autophosphorylation was evaluated by ELISA. GALNT2 down-regulation increased while GALNT2 over-expression reduced ENPP1 expression levels. In addition, GALNT2 down-regulation reduced insulin stimulation of IR, IRS-1 and Akt phosphorylation and insulin inhibition of phosphoenolpyruvate carboxykinase (PEPCK) expression, a key neoglucogenetic enzyme. Our data point to GALNT2 as a novel factor involved in the modulation of ENPP1 expression as well as insulin signaling and action in human liver HepG2 cell

Neutrino transport in accretion disks

We test approximate approaches to solving a neutrino transport problem that presents itself in the analysis of some accretion-disk models. Approximation #1 consists of replacing the full, angular- dependent, distribution function by a two-stream simulation, where the streams are respectively outwardly and inwardly directed, with angles $\cos \theta=\pm 1/\sqrt{3}$ to the vertical. In this approximation the full energy dependence of the distribution function is retained, as are the energy and temperature dependences of the scattering rates. Approximation #2, used in recent works on the subject, replaces the distribution function by an intensity function and the scattering rates by temperature-energy-averaged quantities. We compare the approximations to the results of solving the full Boltzmann equation. Under some interesting conditions, approximation #1 passes the test; approximation #2 does not. We utilize the results of our analysis to construct a toy model of a disc at a temperature and density such that relativistic particles are more abundant than nucleons, and dominate both the opacity and pressure. The nucleons will still provide most of the energy density. In the toy model we take the rate of heat generation (which drives the radiative transfer problem) to be proportional to the nucleon density. The model allows the simultaneous solution of the neutrino transport and hydrostatic equilibrium problems in a disk in which the nucleon density decreases approximately linearly as one moves from the median plane of the disk upwards, reaching zero on the upper boundary.Comment: 8 pages, 5 figures Parentheses added in eqs. 10-1

Primacy of effective communication and its influence on adherence to artemether-lumefantrine treatment for children under five years of age: a qualitative study.

BACKGROUND\ud \ud Prompt access to artemesinin-combination therapy (ACT) is not adequate unless the drug is taken according to treatment guidelines. Adherence to the treatment schedule is important to preserve efficacy of the drug. Although some community based studies have reported fairly high levels of adherence, data on factors influencing adherence to artemether-lumefantrine (AL) treatment schedule remain inadequate. This study was carried-out to explore the provider's instructions to caretakers, caretakers' understanding of the instructions and how that understanding was likely to influence their practice with regard to adhering to AL treatment schedule.\ud \ud METHODS\ud \ud A qualitative study was conducted in five villages in Kilosa district, Tanzania. In-depth interviews were held with providers that included prescribers and dispensers; and caretakers whose children had just received AL treatment. Information was collected on providers' instructions to caretakers regarding dose timing and how to administer AL; and caretakers' understanding of providers' instructions.\ud \ud RESULTS\ud \ud Mismatch was found on providers' instructions as regards to dose timing. Some providers' (dogmatists) instructions were based on strict hourly schedule (conventional) which was likely to lead to administering some doses in awkward hours and completing treatment several hours before the scheduled time. Other providers (pragmatists) based their instruction on the existing circumstances (contextual) which was likely to lead to delays in administering the initial dose with serious treatment outcomes. Findings suggest that, the national treatment guidelines do not provide explicit information on how to address the various scenarios found in the field. A communication gap was also noted in which some important instructions on how to administer the doses were sometimes not provided or were given with false reasons.\ud \ud CONCLUSIONS\ud \ud There is need for a review of the national malaria treatment guidelines to address local context. In the review, emphasis should be put on on-the-job training to address practical problems faced by providers in the course of their work. Further research is needed to determine the implication of completing AL treatment prior to scheduled time

Corrosione sotto sforzo su conserve di tonno sott’olio in banda stagnata

Nel presente lavoro sono stati analizzati alcuni casi di corrosione sotto sforzo (Stress Corrosion Cracking, SCC)su scatolette metalliche in banda stagnata per la conserva di tonno sott’olio. I contenitori metalliciprovenivano da due diversi fabbricanti di barattoli, con carni di diversi operatori del settore alimentare.In entrambi i casi sono state osservate microcricche fini e ramificate da SCC a ridosso delle regioni disaldatura. Dalle analisi chimiche del liquido associato ai prodotti sono state rilevate quantità sensibili di faseacquosa ed elevate concentrazioni di fosfati e cloruri, assieme a concentrazioni minori di bicarbonati e solfati.Gli esami in microscopia elettronica in scansione (SEM/EDS) hanno evidenziato all’interno delle lesionila presenza di prodotti di corrosione dell’acciaio frammisti a quantità sensibili soprattutto di fosfati.Tra i fattori scatenanti l’innesco della SCC hanno sicuramente importanza la separazione di fase acquosae le autotensioni in regione di saldatura. Occorre però anche una specificità dell’accoppiamento metalloambientee, in tal senso, l’ipotesi più probabile è l’abbondante presenza di fosfati in un ambiente acquosopraticamente deaerato. Da quanto osservato, questi anioni sembrano indurre anche inversione di polaritàtra acciaio al carbonio e deposito di stagno. Nel lavoro sono infine dati suggerimenti per minimizzarel’insorgenza di tali danneggiamenti

Adherence to yoga and exercise interventions in a 6-month clinical trial

<p>Abstract</p> <p>Background</p> <p>To determine factors that predict adherence to a mind-body intervention in a randomized trial.</p> <p>Design</p> <p>We analyzed adherence data from a 3-arm trial involving 135 generally healthy seniors 65–85 years of age randomized to a 6-month intervention consisting of: an Iyengar yoga class with home practice, an exercise class with home practice, or a wait-list control group. Outcome measures included cognitive function, mood, fatigue, anxiety, health-related quality of life, and physical measures. Adherence to the intervention was obtained by class attendance and biweekly home practice logs.</p> <p>Results</p> <p>The drop-out rate was 13%. Among the completers of the two active interventions, average yoga class attendance was 77% and home practice occurred 64% of all days. Average exercise class attendance was 69% and home exercise occurred 54% of all days. There were no clear effects of adherence on the significant study outcomes (quality of life and physical measures). Class attendance was significantly correlated with baseline measures of depression, fatigue, and physical components of health-related quality of life. Significant differences in baseline measures were also found between study completers and drop-outs in the active interventions. Adherence was not related to age, gender, or education level.</p> <p>Conclusion</p> <p>Healthy seniors have good attendance at classes with a physically active intervention. Home practice takes place over half of the time. Decreased adherence to a potentially beneficial intervention has the potential to decrease the effect of the intervention in a clinical trial because subjects who might sustain the greatest benefit will receive a lower dose of the intervention and subjects with higher adherence rates may be functioning closer to maximum ability before the intervention. Strategies to maximize adherence among subjects at greater risk for low adherence will be important for future trials, especially complementary treatments requiring greater effort than simple pill-taking.</p