17 research outputs found
Methyl 2-methyl-4-(oxiran-2-ylmethÂoxy)-2H-1,2-benzothiaÂzine-3-carboxylÂate 1,1-dioxide
In the title compound, C14H15NO6S, the thiaÂzine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak interÂmolecular C—H⋯O hydrogen-bonding interÂactions, giving rise to a two-dimensional sheet packing motif. The CH2 group in the methÂoxy linker to the oxirane ring, and the CH group in that ring, exhibit twofold positional disorder. The three-membered oxirane ring is twisted approximately perpendicular with respect to thiaÂzine ring (dihedral angle = 60/86° for the major/minor disorder components). 1,2-BenzothiaÂzines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis