Modeling Repulsive Gravity with Creation

There is a growing interest in the cosmologists for theories with negative energy scalar fields and creation, in order to model a repulsive gravity. The classical steady state cosmology proposed by Bondi, Gold and Hoyle in 1948, was the first such theory which used a negative kinetic energy creation field to invoke creation of matter. We emphasize that creation plays very crucial role in cosmology and provides a natural explanation to the various explosive phenomena occurring in local (z<0.1) and extra galactic universe. We exemplify this point of view by considering the resurrected version of this theory - the quasi-steady state theory, which tries to relate creation events directly to the large scale dynamics of the universe and supplies more natural explanations of the observed phenomena. Although the theory predicts a decelerating universe at the present era, it explains successfully the recent SNe Ia observations (which require an accelerating universe in the standard cosmology), as we show in this paper by performing a Bayesian analysis of the data.Comment: The paper uses an old SNeIa dataset. With the new improved data, for example the updated gold sample (Riess et al, astro-ph/0611572), the fit improves considerably (\chi^2/DoF=197/180 and a probability of goodness-of-fit=18%

Design Evaluation and Temperature Rise Test of Flameproof Induction Motor

The ignition of flammable gases, vapours or dust in presence of oxygen contained in the surrounding atmosphere may lead to explosion. Flameproof three phase induction motors are the most common and frequently used in the process industries such as oil refineries, oil rigs, petrochemicals, fertilizers, etc. The design of flameproof motor is such that it allows and sustain explosion within the enclosure caused by ignition of hazardous gases without transmitting it to the external flammable atmosphere. The enclosure is mechanically strong enough to withstand the explosion pressure developed inside it. To prevent an explosion due to hot spot on the surface of the motor, flameproof induction motors are subjected to heat run test to determine the maximum surface temperature and temperature class with respect to the ignition temperature of the surrounding flammable gas atmosphere. This paper highlights the design features of flameproof motors and their surface temperature classification for different sizes

Einstein energy associated with the Friedmann -Robertson -Walker metric

Following Einstein's definition of Lagrangian density and gravitational field energy density (Einstein, A., Ann. Phys. Lpz., 49, 806 (1916); Einstein, A., Phys. Z., 19, 115 (1918); Pauli, W., {\it Theory of Relativity}, B.I. Publications, Mumbai, 1963, Trans. by G. Field), Tolman derived a general formula for the total matter plus gravitational field energy ($P_0$) of an arbitrary system (Tolman, R.C., Phys. Rev., 35(8), 875 (1930); Tolman, R.C., {\it Relativity, Thermodynamics & Cosmology}, Clarendon Press, Oxford, 1962)); Xulu, S.S., arXiv:hep-th/0308070 (2003)). For a static isolated system, in quasi-Cartesian coordinates, this formula leads to the well known result $P_0 = \int \sqrt{-g} (T_0^0 - T_1^1 -T_2^2 -T_3^3) ~d^3 x$, where $g$ is the determinant of the metric tensor and $T^a_b$ is the energy momentum tensor of the {\em matter}. Though in the literature, this is known as "Tolman Mass", it must be realized that this is essentially "Einstein Mass" because the underlying pseudo-tensor here is due to Einstein. In fact, Landau -Lifshitz obtained the same expression for the "inertial mass" of a static isolated system without using any pseudo-tensor at all and which points to physical significance and correctness of Einstein Mass (Landau, L.D., and Lifshitz, E.M., {\it The Classical Theory of Fields}, Pergamon Press, Oxford, 2th ed., 1962)! For the first time we apply this general formula to find an expression for $P_0$ for the Friedmann- Robertson -Walker (FRW) metric by using the same quasi-Cartesian basis. As we analyze this new result, physically, a spatially flat model having no cosmological constant is suggested. Eventually, it is seen that conservation of $P_0$ is honoured only in the a static limit.Comment: By mistake a marginally different earlier version was loaded, now the journal version is uploade

A study of the angular size-redshift relation for models in which Λ\Lambda decays as the energy density

By modifying the Chen and Wu ansatz, we have investigated some Friedmann models in which $\Lambda$ varies as $\rho$. In order to test the consistency of the models with observations, we study the angular size - redshift relation for 256 ultracompact radio sources selected by Jackson and Dodgson. The angular sizes of these sources were determined by using very long-baseline interferometry in order to avoid any evolutionary effects. The models fit the data very well and require an accelerating universe with a positive cosmological constant. Open, flat and closed models are almost equally probable, though the open model provides a comparatively better fit to the data. The models are found to have intermediate density and imply the existence of dark matter, though not as much as in the canonical Einstein-de Sitter model.Comment: LaTex, 15 pages including 2 figures (Revised version appeared in CQG

Cosmological Models with Variable Gravitational and Cosmological constants in R2R^{2} Gravity

We consider the evolution of a flat Friedmann-Roberstson-Walker Universe in a higher derivative theories, including $\alpha R^{2}$ terms to the Einstein-Hilbert action in the presence of a variable gravitational and cosmological constants. We study here the evolution of the gravitational and cosmological constants in the presence of radiation and matter domination era of the universe. We present here new cosmological solutions which are physically interesting for model building.Comment: 14 pages, no figure. to be published in Int. J. Mod. Phys.

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3\u27UTR AU-rich elements (AREs). Here, we examine the therapeutic potential of targeting HuR using MS-444, a small molecule HuR inhibitor. Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. Mechanistically, MS-444 disrupted HuR cytoplasmic trafficking and released ARE-mRNAs for localization to P-bodies, but did not affect total HuR expression levels. This resulted in MS-444-mediated inhibition of COX-2 and other ARE-mRNA expression levels. Importantly, MS-444 was well tolerated and inhibited xenograft CRC tumor growth through enhanced apoptosis and decreased angiogenesis upon intraperitoneal administration. In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors. These findings provide evidence that therapeutic strategies to target HuR in CRC warrant further investigation in an effort to move this approach to the clinic

Anisotropic Brane Cosmology with Variable GG and Λ\Lambda

In this work, the cosmological implications of brane world scenario are investigated when the gravitational coupling $G$ and the cosmological term $\Lambda$ are not constant but rather there are time variation of them. From observational point of view, these time variations are taken in the form $\frac{\dot{G}}{G}\sim H$ and $\Lambda \sim H^{2}$. The behavior of scale factors and different kinematical parameters are investigated for different possible scenarios where the bulk cosmological constant $\Lambda_{5}$ can be zero, positive or negative.Comment: RevTex, 7 figures, 16 page

The angular size - redshift relation in power-law cosmologies

A linear evolution of the cosmological scale factor is a feature in several models designed to solve the cosmological constant problem via a coupling between scalar or tensor classical fields to the space-time curvature as well as in some alternative gravity theories. In this paper, by assuming a general time dependence of the scale factor, $R \sim t^{\alpha}$, we investigate observational constraints on the dimensionless parameter $\alpha$ from measurements of the angular size for a large sample of milliarcsecond compact radio sources. In particular, we find that a strictly linear evolution, i.e., $\alpha \simeq 1$ is favoured by these data, which is also in agreement with limits obtained from other independent cosmological tests. The dependence of the critical redshift $z_m$ (at which a given angular size takes its minimal value) with the index $\alpha$ is briefly discussed.Comment: 5 pages, 4 figures, LaTe