1,785 research outputs found
The asymmetric sandwich theorem
We discuss the asymmetric sandwich theorem, a generalization of the
Hahn-Banach theorem. As applications, we derive various results on the
existence of linear functionals that include bivariate, trivariate and
quadrivariate generalizations of the Fenchel duality theorem. Most of the
results are about affine functions defined on convex subsets of vector spaces,
rather than linear functions defined on vector spaces. We consider both results
that use a simple boundedness hypothesis (as in Rockafellar's version of the
Fenchel duality theorem) and also results that use Baire's theorem (as in the
Robinson-Attouch-Brezis version of the Fenchel duality theorem). This paper
also contains some new results about metrizable topological vector spaces that
are not necessarily locally convex.Comment: 17 page
Prevalence of qacA/B genes and mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) isolates in the setting of chlorhexidine bathing without mupirocin
OBJECTIVE: We aimed to determine the frequency of qacA/B chlorhexidine tolerance genes and high-level mupirocin resistance among MRSA isolates before and after the introduction of a chlorhexidine (CHG) daily bathing intervention in a surgical intensive care unit (SICU). DESIGN: Retrospective cohort study (2005–2012) SETTING: A large tertiary-care center PATIENTS: Patients admitted to SICU who had MRSA surveillance cultures of the anterior nares METHODS: A random sample of banked MRSA anterior nares isolates recovered during (2005) and after (2006–2012) implementation of a daily CHG bathing protocol was examined for qacA/B genes and high-level mupirocin resistance. Staphylococcal cassette chromosome mec (SCCmec) typing was also performed. RESULTS: Of the 504 randomly selected isolates (63 per year), 36 (7.1%) were qacA/B positive ( + ) and 35 (6.9%) were mupirocin resistant. Of these, 184 (36.5%) isolates were SCCmec type IV. There was a significant trend for increasing qacA/B (P= .02; highest prevalence, 16.9% in 2009 and 2010) and SCCmec type IV (P< .001; highest prevalence, 52.4% in 2012) during the study period. qacA/B( + ) MRSA isolates were more likely to be mupirocin resistant (9 of 36 [25%] qacA/B( + ) vs 26 of 468 [5.6%] qacA/B(−); P= .003). CONCLUSIONS: A long-term, daily CHG bathing protocol was associated with a change in the frequency of qacA/B genes in MRSA isolates recovered from the anterior nares over an 8-year period. This change in the frequency of qacA/B genes is most likely due to patients in those years being exposed in prior admissions. Future studies need to further evaluate the implications of universal CHG daily bathing on MRSA qacA/B genes among hospitalized patients
A stochastic flow rule for granular materials
There have been many attempts to derive continuum models for dense granular
flow, but a general theory is still lacking. Here, we start with Mohr-Coulomb
plasticity for quasi-2D granular materials to calculate (average) stresses and
slip planes, but we propose a "stochastic flow rule" (SFR) to replace the
principle of coaxiality in classical plasticity. The SFR takes into account two
crucial features of granular materials - discreteness and randomness - via
diffusing "spots" of local fluidization, which act as carriers of plasticity.
We postulate that spots perform random walks biased along slip-lines with a
drift direction determined by the stress imbalance upon a local switch from
static to dynamic friction. In the continuum limit (based on a Fokker-Planck
equation for the spot concentration), this simple model is able to predict a
variety of granular flow profiles in flat-bottom silos, annular Couette cells,
flowing heaps, and plate-dragging experiments -- with essentially no fitting
parameters -- although it is only expected to function where material is at
incipient failure and slip-lines are inadmissible. For special cases of
admissible slip-lines, such as plate dragging under a heavy load or flow down
an inclined plane, we postulate a transition to rate-dependent Bagnold
rheology, where flow occurs by sliding shear planes. With different yield
criteria, the SFR provides a general framework for multiscale modeling of
plasticity in amorphous materials, cycling between continuum limit-state stress
calculations, meso-scale spot random walks, and microscopic particle
relaxation
Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed complications. However, the mechanisms underlying blood-brain barrier opening are poorly understood. Here we demonstrate the role of the neurotransmitter glutamate in modulating early barrier permeability in vivo Using intravital microscopy, we show that recurrent seizures and the associated excessive glutamate release lead to increased vascular permeability in the rat cerebral cortex, through activation of NMDA receptors. NMDA receptor antagonists reduce barrier permeability in the peri-ischemic brain, whereas neuronal activation using high-intensity magnetic stimulation increases barrier permeability and facilitates drug delivery. Finally, we conducted a double-blind clinical trial in patients with malignant glial tumors, using contrast-enhanced magnetic resonance imaging to quantitatively assess blood-brain barrier permeability. We demonstrate the safety of stimulation that efficiently increased blood-brain barrier permeability in 10 of 15 patients with malignant glial tumors. We suggest a novel mechanism for the bidirectional modulation of brain vascular permeability toward increased drug delivery and prevention of delayed complications in brain disorders.
SIGNIFICANCE STATEMENT:
In this study, we reveal a new mechanism that governs blood-brain barrier (BBB) function in the rat cerebral cortex, and, by using the discovered mechanism, we demonstrate bidirectional control over brain endothelial permeability. Obviously, the clinical potential of manipulating BBB permeability for neuroprotection and drug delivery is immense, as we show in preclinical and proof-of-concept clinical studies. This study addresses an unmet need to induce transient BBB opening for drug delivery in patients with malignant brain tumors and effectively facilitate BBB closure in neurological disorders
Tensile Fracture of Welded Polymer Interfaces: Miscibility, Entanglements and Crazing
Large-scale molecular simulations are performed to investigate tensile
failure of polymer interfaces as a function of welding time . Changes in the
tensile stress, mode of failure and interfacial fracture energy are
correlated to changes in the interfacial entanglements as determined from
Primitive Path Analysis. Bulk polymers fail through craze formation, followed
by craze breakdown through chain scission. At small welded interfaces are
not strong enough to support craze formation and fail at small strains through
chain pullout at the interface. Once chains have formed an average of about one
entanglement across the interface, a stable craze is formed throughout the
sample. The failure stress of the craze rises with welding time and the mode of
craze breakdown changes from chain pullout to chain scission as the interface
approaches bulk strength. The interfacial fracture energy is calculated
by coupling the simulation results to a continuum fracture mechanics model. As
in experiment, increases as before saturating at the average
bulk fracture energy . As in previous simulations of shear strength,
saturation coincides with the recovery of the bulk entanglement density. Before
saturation, is proportional to the areal density of interfacial
entanglements. Immiscibiltiy limits interdiffusion and thus suppresses
entanglements at the interface. Even small degrees of immisciblity reduce
interfacial entanglements enough that failure occurs by chain pullout and
Liesegang patterns: Effect of dissociation of the invading electrolyte
The effect of dissociation of the invading electrolyte on the formation of
Liesegang bands is investigated. We find, using organic compounds with known
dissociation constants, that the spacing coefficient, 1+p, that characterizes
the position of the n-th band as x_n ~ (1+p)^n, decreases with increasing
dissociation constant, K_d. Theoretical arguments are developed to explain
these experimental findings and to calculate explicitly the K_d dependence of
1+p.Comment: RevTex, 8 pages, 3 eps figure
Drift and Diffusion in Periodically Driven Renewal Processes
We consider the drift and diffusion properties of periodically driven renewal
processes. These processes are defined by a periodically time dependent waiting
time distribution, which governs the interval between subsequent events. We
show that the growth of the cumulants of the number of events is asymptotically
periodic and develop a theory which relates these periodic growth coefficients
to the waiting time distribution defining the periodic renewal process. The
first two coefficients, which are the mean frequency and effective diffusion
coefficient of the number of events are considered in greater detail. They may
be used to quantify stochastic synchronization.Comment: 29 pages, 6 figures, submitted to Journal of Statistical Physic
Stochastic resonance in a non Markovian discrete state model for excitable systems
We study a non Markovian three state model, subjected to an external periodic
signal. This model is intended to describe an excitable systems with periodical
driving. In the limit of a small amplitude of the external signal we derive
expressions for the spectral power amplification and the signal to noise ratio
as well as for the inter-spike interval distribution.Comment: 5 pages, 3 figure
Band Formation during Gaseous Diffusion in Aerogels
We study experimentally how gaseous HCl and NH_3 diffuse from opposite sides
of and react in silica aerogel rods with porosity of 92 % and average pore size
of about 50 nm. The reaction leads to solid NH_4Cl, which is deposited in thin
sheet-like structures. We present a numerical study of the phenomenon. Due to
the difference in boundary conditions between this system and those usually
studied, we find the sheet-like structures in the aerogel to differ
significantly from older studies. The influence of random nucleation centers
and inhomogeneities in the aerogel is studied numerically.Comment: 7 pages RevTex and 8 figures. Figs. 4-8 in Postscript, Figs. 1-3 on
request from author
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