First report of Pleuroceras pseudoplatani on Acer rubrum, A. griseum, A. saccharinum, A. negundo, A. circinatum and A. macrophyllum in Scotland

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Mortality and basal area growth following precommercial thinning in stands affected by Armillaria, Laminated and Tomentosus root diseases in southern British Columbia

Precommercial thinning aims to reduce the density of immature stands to stimulate growth of well-spaced crop trees of preferred species and free from defects and disease. The chronic persistence of Armillaria, Laminated and Tomentosus root diseases in coniferous forests of British Columbia, Canada may offset potential gains in timber yield of commercially important tree species by creating stumps that the fungi utilize as an energy source to infect neighbouring trees. In juvenile plantations and naturally regenerated stands in six biogeoclimatic (BEC) zones with evidence of root disease caused by Armillaria ostoyae (8 sites), Coniferiporia sulphurascens (2 sites) or Onnia tomentosa (1 site), five of ten 20 m square plots per site were randomly selected for thinning to British Columbia Ministry of Forests specifications. Crop tree diameter at breast height and mortality from all causes were recorded at establishment and periodically thereafter up to 19 years post-thinning. Logistic regression analysis of mortality rates showed significant differences among root disease pathogens, between planted and natural stands, and among ecological zones. Yet over all sites, differences between thinned and control plots were not significant. At the final assessment, crop tree basal area was higher in thinned than in control plots at 10 of 11 sites. Root disease, including infected and dead trees and other lethal biotic and abiotic agents, reduced potential yield in both treatments (thinned and control). At several Armillaria sites, mortality was slightly to substantially higher in thinned than in control plots, suggesting that thinning can increase the amount and potential of inoculum which may continue to adversely impact productivity of those stands. Recommendations for silvicultural management of the three root diseases are discussed

Canine Uterine Bacterial Infection Induces Upregulation of Proteolysis-Related Genes and Downregulation of Homeobox and Zinc Finger Factors

BACKGROUND: Bacterial infection with the severe complication of sepsis is a frequent and serious condition, being a major cause of death worldwide. To cope with the plethora of occurring bacterial infections there is therefore an urgent need to identify molecular mechanisms operating during the host response, in order both to identify potential targets for therapeutic intervention and to identify biomarkers for disease. Here we addressed this issue by studying global gene expression in uteri from female dogs suffering from spontaneously occurring uterine bacterial infection. PRINCIPAL FINDINGS: The analysis showed that almost 800 genes were significantly (p<0.05) upregulated (>2-fold) in the uteri of diseased animals. Among these were numerous chemokine and cytokine genes, as well as genes associated with inflammatory cell extravasation, anti-bacterial action, the complement system and innate immune responses, as well as proteoglycan-associated genes. There was also a striking representation of genes associated with proteolysis. Robust upregulation of immunoglobulin components and genes involved in antigen presentation was also evident, indicating elaboration of a strong adaptive immune response. The bacterial infection was also associated with a significant downregulation of almost 700 genes, of which various homeobox and zinc finger transcription factors were highly represented. CONCLUSIONS/SIGNIFICANCE: Together, these finding outline the molecular patterns involved in bacterial infection of the uterus. The study identified altered expression of numerous genes not previously implicated in bacterial disease, and several of these may be evaluated for potential as biomarkers of disease or as therapeutic targets. Importantly, since humans and dogs show genetic similarity and develop diseases that share many characteristics, the molecular events identified here are likely to reflect the corresponding situation in humans afflicted by similar disease

The Organization of Working Memory Networks is Shaped by Early Sensory Experience

Early deafness results in crossmodal reorganization of the superior temporal cortex (STC). Here, we investigated the effect of deafness on cognitive processing. Specifically, we studied the reorganization, due to deafness and sign language (SL) knowledge, of linguistic and nonlinguistic visual working memory (WM). We conducted an fMRI experiment in groups that differed in their hearing status and SL knowledge: deaf native signers, and hearing native signers, hearing nonsigners. Participants performed a 2-back WM task and a control task. Stimuli were signs from British Sign Language (BSL) or moving nonsense objects in the form of point-light displays. We found characteristic WM activations in fronto-parietal regions in all groups. However, deaf participants also recruited bilateral posterior STC during the WM task, independently of the linguistic content of the stimuli, and showed less activation in fronto-parietal regions. Resting-state connectivity analysis showed increased connectivity between frontal regions and STC in deaf compared to hearing individuals. WM for signs did not elicit differential activations, suggesting that SL WM does not rely on modality-specific linguistic processing. These findings suggest that WM networks are reorganized due to early deafness, and that the organization of cognitive networks is shaped by the nature of the sensory inputs available during development

Postmortem Changes in Myoglobin Content in Organs

Postmortem changes in myoglobin concentrations in blood and organs were investigated using an enzyme immunoassay by animal experiments in combination with immunohistochemical staining of human cases. Blood myoglobin concentrations were found to increase drastically within a very short time after death. Those in striated muscle, however, did not change by day 14 postmortem. Myoglobin content in the liver and kidney increased slightly by day 5 postmortem, and more obviously by day 7 or later. However, almost no change was observed by day 5 in the kidney when the renal artery and vein had been ligated just after death. In the thyroid gland and the lung, the myoglobin content markedly increased by day 7 postmortem, with the logarithmical values rising nearly linearly as the time after death passed. In the thyroid gland, concentrations reached the level of the striated muscle. The mechanisms of postmortem myoglobin increase in organs are thought to be direct diffusion from the striated muscle and/or distribution through the blood. To estimate the postmortem interval, the determination of myoglobin content in the thyroid gland or the lung appears to be useful

Fluid flow and heat transfer analysis of TEFC machine end regions using more realistic end-winding geometry

Here, a typical small low-voltage totally enclosed fan-cooled (TEFC) motor (output power ∼10 kW) has been studied using computational fluid dynamics. The complexity of the end-winding geometries, often consisting of several insulated copper strands bound together, provides a challenge to the modelling and analysis of heat transfer and fluid flow phenomena occurring in the end region, which typically is an area of most interest for thermal management. Approximated geometries are usually employed in order to model the end windings to reduce the analysis time and cost. This paper presents a comparison of two cases, a typical simplified geometry and a more realistic geometry of end windings, and uses these cases to highlight the challenges and impact on predicted heat transfer. A comparison of the two models indicate that the different representations of end winding geometries can affect the heat dissipation rate through the outer housing by up to 45%

Neural Networks Supporting Phoneme Monitoring Are Modulated by Phonology but Not Lexicality or Iconicity: Evidence From British and Swedish Sign Language

Sign languages are natural languages in the visual domain. Because they lack a written form, they provide a sharper tool than spoken languages for investigating lexicality effects which may be confounded by orthographic processing. In a previous study, we showed that the neural networks supporting phoneme monitoring in deaf British Sign Language (BSL) users are modulated by phonology but not lexicality or iconicity. In the present study, we investigated whether this pattern generalizes to deaf Swedish Sign Language (SSL) users. British and SSLs have a largely overlapping phoneme inventory but are mutually unintelligible because lexical overlap is small. This is important because it means that even when signs lexicalized in BSL are unintelligible to users of SSL they are usually still phonologically acceptable. During fMRI scanning, deaf users of the two different sign languages monitored signs that were lexicalized in either one or both of those languages for phonologically contrastive elements. Neural activation patterns relating to different linguistic levels of processing were similar across SLs; in particular, we found no effect of lexicality, supporting the notion that apparent lexicality effects on sublexical processing of speech may be driven by orthographic strategies. As expected, we found an effect of phonology but not iconicity. Further, there was a difference in neural activation between the two groups in a motion-processing region of the left occipital cortex, possibly driven by cultural differences, such as education. Importantly, this difference was not modulated by the linguistic characteristics of the material, underscoring the robustness of the neural activation patterns relating to different linguistic levels of processing

Application of Spectral Kurtosis to Characterize Amplitude Variability in Power Systems’ Harmonics

The highly-changing concept of Power Quality (PQ) needs to be continuously reformulated due to the new schemas of the power grid or Smart Grid (SG). In general, the spectral content is characterized by their averaged or extreme values. However, new PQ events may consist of large variations in amplitude that occur in a short time or small variations in amplitude that take place continuously. Thus, the former second-order techniques are not suitable to monitor the dynamics of the power spectrum. In this work, a strategy based on Spectral Kurtosis (SK) is introduced to detect frequency components with a constant amplitude trend, which accounts for amplitude values’ dispersion related to the mean value of that spectral component. SK has been proven to measure frequency components that follow a constant amplitude trend. Two practical real-life cases have been considered: electric current time-series from an arc furnace and the power grid voltage supply. Both cases confirm that the more concentrated the amplitude values are around the mean value, the lower the SK values are. All this confirms SK as an effective tool for evaluating frequency components with a constant amplitude trend, being able to provide information beyond maximum variation around the mean value and giving a progressive index of value dispersion around the mean amplitude value, for each frequency component