15 research outputs found
Pyogenic Granuloma in an Atypical Location Following Isotretinoin Treatment
Interesting Medical Imag
Sexual Dysfunction and Atopic Dermatitis: A Systematic Review
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin whose main symptom
is pruritus and may affect all age ranges. Regarding the prevalence, it has been estimated at around
10% of the world population. Many concomitant diseases have been associated with AD, but the
causal relationship between AD and psychological impairment has not been clearly established.
Scientific literature studying the probable association between male or female sexual dysfunction
and dermatological pathology is limited, even more so in AD. This systematic review was conducted
following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
reporting guidelines and the Cochrane Collaboration methodology for systematic reviews. All
relevant articles in English were identified through a search from inception to 10 December 2020,
including the following databases: Medline (via PubMed), Scopus,Web of Science Core Collection,
and SciELO. The results of the search were compiled using the COVIDENCE software for systematic
reviews. The methodological quality of the included studies was done using the “Quality Assessment
Tool for Observational Cohort and Cross-Sectional Studies” and the “Quality Assessment of Case-
Control Studies” developed by the National Heart, Lung, and Blood Institute, National Institutes
of Health (NIH). Our search yielded potentially relevant studies. Five studies that evaluated the
prevalence of sexual dysfunction in atopic dermatitis were retrieved after applying the selection
criteria. The present systematic review achieved data from 8088 patients with atopic dermatitis from
four articles. Sample sizes for atopic dermatitis patients ranged from 266 to 3997. We identified one
cohort study with four years of follow-up, three studies with a cross-sectional design, and one casecontrol
study. Three studies reported data disaggregated by the severity of atopic dermatitis. Two
studies included healthy controls with a total sample size of 1,747,755 subjects. Two studies compared
data with other dermatological conditions such as psoriasis. In conclusion, we can establish that
unlike other psychological comorbidities such as anxiety and depression, sexual dysfunction is a field
scarcely explored in the literature. This sexual dysfunction focuses on the male sex in large population
studies and in clinical diagnoses without exploring it through specific and validated questionnaires
in this regard. Further studies focused on both genders are needed. It is important to correlate
this sexual dysfunction with the severity of the disease, previous treatments, and cardiovascular
comorbidities
Basic Quality Controls Used in Skin Tissue Engineering
Supported by PE-0395-2019 from Consejería de Salud y Familias, Junta de Andalucía, Spain.Reconstruction of skin defects is often a challenging effort due to the currently limited
reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to
replace or repair diseased or damaged tissues from the patient’s own cells. A substantial number of
tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo
showing promising results in the preclinical stage. However, only a few constructs have been used in
the clinic. The lack of standardization in evaluation methods employed may in part be responsible
for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating
the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are proposed.PE-0395-2019 from Consejería de Salud y Familias, Junta de Andalucía, Spai
Chilblain-like lesions in pediatrics dermatological outpatients during the COVID-19 outbreak.
In Spain, with full confinement measures and coinciding with the pandemic, pediatricians and dermatologists have received, through teledermatology/teleconsultation and social networks, a barrage of diverse images, which have subsequently allowed us to approach some of them by direct physical examination of early and late skin manifestations associated with SARS-Cov-2 infection. We designed a retrospective, cross-sectional study to evaluate the dermatological care of all those patients under the age of 16 who consulted, in person or telematically, for acral lesions (chilblain-like or erythema multiforme-like) in the context of the Coronavirus disease (COVID-19) pandemic, since 15 March 2020 to 24 April 2020, both included in the health area of the Hospital Universitario San Cecilio de Granada. Of all the patients collected, 18 (66%) were male and the overall mean age was 14.44 years. All lacked a personal history of interest and denied previous episodes of chilblains or Raynaud's phenomenon/disease. The clinic was limited to purpuric lesions located on acral regions distributed on hands and feet. Dermatologists and pediatricians should be aware of the lesions associated with COVID-19 infection and their possible complications. It remains to be identified if there are different dermatological patterns in the pediatric and adult population