A Combined Component-Based Approach for the Design of Distributed Software Systems

Component-based software development enables the construction of software artefacts by assembling binary units of production, distribution and deployment, the so-called components. Several approaches to component-based development have been proposed recently. Most of these approaches are based on the Unified Modeling Language (UML). UML has been increasingly used in component-based development, despite some shortcomings of this language. This paper presents a methodology for the design of component-based applications that combines a model-based approach with a UML-based approach. This combined approach tackles some of the limitations of UML, allowing a better control of the design proces

Clinical outcomes in a subpopulation of adults with Morquio A syndrome: results from a long-term extension study of elosulfase alfa

Background: This post hoc subanalysis examined outcomes in adult patients with Morquio A (mucopolysaccharidosis IVA) who received enzyme replacement therapy (ERT) with elosulfase alfa over a 120-weeks period. Patients ≥18 years of age evaluated in an open-label, long-term extension study of elosulfase alfa (modified per protocol [MPP], n = 32; intent-to-treat [ITT], n = 37; MOR-005; NCT01415427) were compared with the ≥18-year-old untreated population with 2-years follow-up from a Morquio A natural history study (n = 10; MorCAP; NCT00787995). The MOR-005 MPP population excluded patients who underwent orthopedic surgical procedures or were noncompliant with study protocol (defined as missing ≥20% of ERT infusions). No MorCAP patients underwent orthopedic surgical procedures during the relevant time period. Endurance was assessed by the 6-min walk test (6MWT) and 3-min stair climb test (3MSCT). Activities of daily living (ADLs) were assessed by the MPS Health Assessment Questionnaire (MPS HAQ). / Results: Least squares (LS) mean (SE) 6MWT distances increased by 34.9 (11.7) m (MPP) and 30.5 (10.8) m (ITT) by week 120; LS mean (SE) change in 3MSCT at week 120 was 6.7 (1.8) stairs/min (MPP) and 5.9 (1.7) stairs/min (ITT). MorCAP patients showed no improvement in 6MWT distance or 3MSCT over a similar period of time. Pulmonary function measures remained unchanged in both MOR-005 and MorCAP adults. All MPS HAQ domain scores improved in MOR-005 adults, whereas MorCAP adults had unchanged caregiver assistance and mobility outcomes and worsened self-care outcomes. / Conclusions: Long-term ERT in adult patients with Morquio A was associated with increased endurance and improvement in performance of ADLs. / Trial registration: Trial Registration NCT01415427. Name of registry: Long-Term Efficacy and Safety Extension Study of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome). Registered 8 August 2011, retrospectively registered

Mapping the business model canvas to ArchiMate

Many IT projects fail to succeed in the market, as they start purely from technology. Much effort is therefore wasted, while the potential benefits are not realized. We argue that the design process should start with creating a business model, which is then translated to an architecture to ensure fitness for market of the future system. Therefore, we propose a mapping from Osterwalder’s business modeling canvas and ontology to the enterprise architecture modeling standard ArchiMate, which makes the above translation possible and represents a formal basis for business modeling in ArchiMate. A case study illustrates the mapping between the two languages

Marginal increase of sunitinib exposure by grapefruit juice

Clinical Oncolog

The dynamics of expanding mangroves in New Zealand

In contrast to the global trend of mangrove decline, New Zealand mangroves are rapidly expanding, facilitated by elevated sediment inputs in coastal waters as a consequence of large-scale land use changes following European settlement. New Zealand mangroves are at the southern limit of the global mangrove extent, which limits the tree height of Avicennia marina var. australasica, the only mangrove species present. Mangroves in New Zealand thrive in the sheltered environments of infilling drowned river valleys with abundant supply of fine terrigenous sediments, showing various stages of mangrove succession and expansion dynamics. Bio-physical interactions and carbon dynamics in these expanding temperate mangrove systems show similarities to, but also differ from those in tropical mangrove forests, for instance due to the limited height and complexity of the mangrove communities. Likewise, ecosystem services provided by New Zealand mangroves deviate from those offered by tropical mangroves. In particular, the association of mangrove expansion with the accumulation of (the increased supply of) fine sediments and the consequent change of estuarine ecosystems, has provoked a negative perception of mangrove expansion and subsequently led to mangrove clearance. Over recent decades, a body of knowledge has been developed regarding the planning and decision making relating to mangrove removal, yet there are still effects that are unknown, for example with respect to the post-clearance recovery of the original sandflat ecosystems. In this chapter we discuss the dynamics of New Zealand’s expanding mangroves from a range of viewpoints, with the aim of elucidating the possible contributions of expanding mangroves to coastal ecosystem services, now and in the future. This chapter also reviews current policies and practice regarding mangrove removal in New Zealand and addresses the (un)known effects of mangrove clearance. These combined insights may contribute to the development of integrated coastal management strategies that recognise the full potential of expanding mangrove ecosystems

A provider based accounting architecture

This paper presents a novel content accounting architecture. Content accounting is becoming increasingly important since it is anticipated that in the near future more billable content on the Internet will be published. The architecture presented in this paper has a distributed functionality and an innovative view with respect to the payment system that is incorporated. The architecture enables outsourcing of the accounting functions. In particular it is shown how Internet Service Providers can be involved in the billing function. The proposed payment system is worldwide applicable and allows online, instant and small payments to be made for a number of content types and units. An important characteristic of this payment system is that customers can always use the same payment mechanism regardless the expectations and requirements of the other (paid) party

Modelling and analysing interoperability in service compositions using COSMO

A service composition process typically involves multiple service models. These models may represent the composite and composed services from distinct perspectives, e.g. to model the role of some system that is involved in a service, and at distinct abstraction levels, e.g. to model the goal, interface or orchestration of some service. The consistency among these models needs to be maintained in order to guarantee the correctness of the composition process. Two types of consistency relations are distinguished: interoperability, which concerns the ability of different roles to interoperate, and conformance, which concerns the correct implementation of an abstract model by a more concrete model. This paper gives an overview of the various types of models that may be used in service composition, and explains when interoperability and conformance need to be assessed during the composition process. The paper further focuses on techniques to describe and analyse the interoperability relation using concepts from the COSMO framework. The choice of COSMO allows one to address both interoperability and conformance within a single conceptual framework. For techniques to describe and analyse the conformance relation reference is made to earlier work. Examples are presented to illustrate how different types of models can be used during the service composition process and how interoperability and conformance among these models can be assessed