Experimental study on mechanical and acoustic emission characteristics of sedimentary sandstone under different loading rates

In the field of rock engineering, complexity of stress environment is an important factor affecting its stability. Thus, in view of fracture mechanism of rock under different loading rates within the scope of quasi-static strain rate, four groups of uniaxial compression tests with different strain rates were carried out on sandstone specimens, and strength, deformation, failure modes and acoustic emission characteristics of specimens were compared and analyzed. Furthermore, the fracture mechanism was discussed from the perspective of fracture characteristics based on fractal dimension, crack propagation law inverted through acoustic emission b-value, and micro fracture morphology. The results showed that as the strain rate increased from 10 to 5 s−1 to 10−2 s−1, the fractal dimension of rock fragments increased, and the fractal dimension of rock fragments increased by 9.66%, 7.32%, and 3.77% successively for every 10 times increase in strain rate, which means that the equivalent size of fragments was getting smaller, and the fragmentation feature was becoming increasingly prominent. The crack propagation process based on acoustic emission b-value showed that with the increase of loading rate, the specimen entered the rapid crack propagation stage earlier, in order of 68%, 66%, 29%, and 22% of peak stress. Moreover, the microscopic fracture morphology showed that with the increase of loading rate, transgranular phenomenon was clear, and the fracture morphology changed from smooth to rough. That meant that the fracture of sandstone rock at high loading rates was mainly caused by the propagation of large cracks, which was different from the slow process of initiation, convergence and re-propagation of small cracks at low strain rates

Tunable Interband Transitions in Twisted h-BN/Graphene Heterostructures

In twisted h-BN/graphene heterostructures, the complex electronic properties of the fast-traveling electron gas in graphene are usually considered to be fully revealed. However, the randomly twisted heterostructures may also have unexpected transition behaviors, which may influence the device performance. Here, we study the twist angle-dependent coupling effects of h-BN/graphene heterostructures using monochromatic electron energy loss spectroscopy. We find that the moir\'e potentials alter the band structure of graphene, resulting in a redshift of the intralayer transition at the M-point, which becomes more pronounced up to 0.25 eV with increasing twist angle. Furthermore, the twisting of the Brillouin zone of h-BN relative to the graphene M-point leads to tunable vertical transition energies in the range of 5.1-5.6 eV. Our findings indicate that twist-coupling effects of van der Waals heterostructures should be carefully considered in device fabrications, and the continuously tunable interband transitions through the twist angle can serve as a new degree of freedom to design optoelectrical devices

Neutrophil elastase as a potential biomarker related to the prognosis of gastric cancer and immune cell infiltration in the tumor immune microenvironment

Abstract Exploring biomarkers interrelated the tumor immune microenvironment (TIME) provides novel ideas for predicting the prognosis of gastric cancer (GC) and developing new treatment strategies. We analyzed the differential gene expression levels between the high and low StromalScore and ImmuneScore groups. Neutrophil elastase (ELANE) was evaluated as a potential biomarker by conducting intersection analysis of the protein–protein interaction network and univariate Cox regression analysis. The expression of ELANE was evaluated by immunohistochemistry. Its prognostic value was evaluated using Kaplan–Meier (K–M) survival curves and multivariate Cox regression analysis and its potential biological molecular mechanism was examined by gene set enrichment analysis (GSEA). We applied the CIBERSORT computing method to analyze the relationship between ELANE and tumor immune-infiltrating cells (TIICs). K–M survival curve showed that higher ELANE expression was closely related to shorter overall survival. The Cox regression analysis indicated that the high expression of ELANE was an independent prognostic risk factor in patients with GC. The GSEA revealed that genes in the ELANE high-expression group were involved in the signaling pathways regulating immune response; genes in the ELANE low-expression group were involved in the signaling pathways that regulate metabolism. ELANE might be participate in the change of TIME from immunodominant to metabolically dominant and its expression was closely related to tumor mutation burden and multiple TIICs. ELANE is a potential biomarker for predicting the GC patients’ survival and prognosis. It influences the tumor immune cell infiltration in the TIME, and affects the TIME to maintain their immune status

Preparation and Stability of Inorganic Solidified Foam for Preventing Coal Fires

Inorganic solidified foam (ISF) is a novel material for preventing coal fires. This paper presents the preparation process and working principle of main installations. Besides, aqueous foam with expansion ratio of 28 and 30 min drainage rate of 13% was prepared. Stability of foam fluid was studied in terms of stability coefficient, by varying water-slurry ratio, fly ash replacement ratio of cement, and aqueous foam volume alternatively. Light microscope was utilized to analyze the dynamic change of bubble wall of foam fluid and stability principle was proposed. In order to further enhance the stability of ISF, different dosage of calcium fluoroaluminate was added to ISF specimens whose stability coefficient was tested and change of hydration products was detected by scanning electron microscope (SEM). The outcomes indicated that calcium fluoroaluminate could enhance the stability coefficient of ISF and compact hydration products formed in cell wall of ISF; naturally, the stability principle of ISF was proved right. Based on above-mentioned experimental contents, ISF with stability coefficient of 95% and foam expansion ratio of 5 was prepared, which could sufficiently satisfy field process requirements on plugging air leakage and thermal insulation

Dynamic Response Analysis of Roadway Surrounding Rock Induced by Dynamic Load under the Action of Hard and Thick Rock Stratum

In the process of coal seam mining, there are often hard thick key layers in the overlying strata. Due to the high strength and good integrity of the hard thick key layer, after the hard thick key layer is broken, the overlying strata will collapse and lose stability in a large area, which is very easy to induce dynamic disasters such as rock burst, mine earthquake, coal wall caving, and roof slab caving. Aiming at the hard and thick key layer overlying the working face, the dynamic response of the mine under the strong mine earthquake induced by the breaking of the main key layer of high-level magmatic rock is numerically simulated and analyzed by using FLAC2D numerical simulation software, and the variation laws of the stress field, displacement field, and velocity field of the coal seam roadway under different boundary conditions and different focal heights are studied. The research shows that the roof of solid coal roadway is prone to vibration in a small range, and the displacement increases and decreases with the disturbance. The displacement of the floor and two sides of the solid coal roadway and the top floor and two sides of the roadway along the goaf continues to increase in the initial stage of the disturbance, and the displacement will remain stable with the continuation of the disturbance. The displacement of both sides and roof and floor of gob roadway can reach stability in the later stage of disturbance, and with the increase of the number of adjacent goaf, the longer it takes for the displacement of surrounding rock to reach stability. When the focal height is lower than 90 m, the variation of surrounding rock response increases sharply with the decrease of focal height. When a strong earthquake occurs in the low rock stratum, the impact damage of roadway surrounding rock is almost inevitable. The influence degree of strong earthquake on the stability of roadway surrounding rock is arranged as follows: gob-side roadway (mined out on one side) > solid coal roadway (mined out on both sides) > solid coal roadway (mined out on one side). The evolution process also shows that the working face boundary conditions have an important influence on the energy propagation of mine earthquake. With the increase of the number of adjacent goafs, the faster the energy attenuation rate of mine earthquake propagation is. The research results have important reference significance for the safe mining of working face under similar geological conditions